Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308514422> ?p ?o ?g. }
- W4308514422 endingPage "13593" @default.
- W4308514422 startingPage "13593" @default.
- W4308514422 abstract "Neurotrophins such as nerve growth factor (ngf) and brain-derived neurotrophic factor (bdnf) play important roles in the central nervous system. They are potential therapeutic drugs for the treatment of neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. In this study, we investigated the neurotrophic properties of triterpenes isolated from fruiting bodies of Laetiporus sulphureus and a mycelial culture of Antrodia sp. MUCL 56049. The structures of the isolated compounds were elucidated based on nuclear magnetic resonance (NMR) spectroscopy in combination with high-resolution electrospray mass spectrometry (HR-ESIMS). The secondary metabolites were tested for neurotrophin (ngf and bdnf) expression levels on human astrocytoma 1321N1 cells. Neurite outgrowth activity using rat pheochromocytoma (PC-12) cells was also determined. Twelve triterpenoids were isolated, of which several potently stimulated the expression of neurotrophic factors, namely, ngf (sulphurenic acid, 15α-dehydroxytrametenolic acid, fomefficinic acid D, and 16α-hydroxyeburicoic acid) and bdnf (sulphurenic acid and 15α-dehydroxytrametenolic acid), respectively. The triterpenes also potentiated ngf-induced neurite outgrowth in PC-12 cells. This is, to the best of our knowledge, the first report on the compound class of lanostanes in direct relation to bdnf and ngf enhancement. These compounds are widespread in medicinal mushrooms; hence, they appear promising as a starting point for the development of drugs and mycopharmaceuticals to combat neurodegenerative diseases. Interestingly, they do not show any pronounced cytotoxicity and may, therefore, be better suited for therapy than many other neurotrophic compounds that were previously reported." @default.
- W4308514422 created "2022-11-12" @default.
- W4308514422 creator A5026672856 @default.
- W4308514422 creator A5041246966 @default.
- W4308514422 creator A5042262321 @default.
- W4308514422 creator A5043135930 @default.
- W4308514422 creator A5047793709 @default.
- W4308514422 creator A5056364767 @default.
- W4308514422 creator A5061788478 @default.
- W4308514422 creator A5066456827 @default.
- W4308514422 creator A5071201906 @default.
- W4308514422 creator A5080953087 @default.
- W4308514422 creator A5085154532 @default.
- W4308514422 date "2022-11-06" @default.
- W4308514422 modified "2023-10-14" @default.
- W4308514422 title "Neurotrophic and Immunomodulatory Lanostane Triterpenoids from Wood-Inhabiting Basidiomycota" @default.
- W4308514422 cites W1537174964 @default.
- W4308514422 cites W1894263044 @default.
- W4308514422 cites W1906069325 @default.
- W4308514422 cites W1970259146 @default.
- W4308514422 cites W1970587959 @default.
- W4308514422 cites W1988948899 @default.
- W4308514422 cites W1995816599 @default.
- W4308514422 cites W1997645270 @default.
- W4308514422 cites W2005000574 @default.
- W4308514422 cites W2007046568 @default.
- W4308514422 cites W2014873657 @default.
- W4308514422 cites W2023482744 @default.
- W4308514422 cites W2038056588 @default.
- W4308514422 cites W2041634592 @default.
- W4308514422 cites W2042513058 @default.
- W4308514422 cites W2046587659 @default.
- W4308514422 cites W2047260938 @default.
- W4308514422 cites W2053158684 @default.
- W4308514422 cites W2080337759 @default.
- W4308514422 cites W2081105855 @default.
- W4308514422 cites W2111929378 @default.
- W4308514422 cites W2112683779 @default.
- W4308514422 cites W2117916227 @default.
- W4308514422 cites W2120377313 @default.
- W4308514422 cites W2123826351 @default.
- W4308514422 cites W2126409614 @default.
- W4308514422 cites W2139565721 @default.
- W4308514422 cites W2163931885 @default.
- W4308514422 cites W2168090137 @default.
- W4308514422 cites W2234732027 @default.
- W4308514422 cites W2482337617 @default.
- W4308514422 cites W2511435922 @default.
- W4308514422 cites W2534194108 @default.
- W4308514422 cites W2550448757 @default.
- W4308514422 cites W2607275277 @default.
- W4308514422 cites W2608196481 @default.
- W4308514422 cites W2767052194 @default.
- W4308514422 cites W2790923440 @default.
- W4308514422 cites W2885526443 @default.
- W4308514422 cites W2898466331 @default.
- W4308514422 cites W2913047781 @default.
- W4308514422 cites W2937918594 @default.
- W4308514422 cites W2954968155 @default.
- W4308514422 cites W2959131130 @default.
- W4308514422 cites W2978673693 @default.
- W4308514422 cites W3015943612 @default.
- W4308514422 cites W3092852313 @default.
- W4308514422 cites W3165481569 @default.
- W4308514422 cites W3215281642 @default.
- W4308514422 cites W4295928235 @default.
- W4308514422 cites W881328202 @default.
- W4308514422 doi "https://doi.org/10.3390/ijms232113593" @default.
- W4308514422 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36362380" @default.
- W4308514422 hasPublicationYear "2022" @default.
- W4308514422 type Work @default.
- W4308514422 citedByCount "5" @default.
- W4308514422 countsByYear W43085144222023 @default.
- W4308514422 crossrefType "journal-article" @default.
- W4308514422 hasAuthorship W4308514422A5026672856 @default.
- W4308514422 hasAuthorship W4308514422A5041246966 @default.
- W4308514422 hasAuthorship W4308514422A5042262321 @default.
- W4308514422 hasAuthorship W4308514422A5043135930 @default.
- W4308514422 hasAuthorship W4308514422A5047793709 @default.
- W4308514422 hasAuthorship W4308514422A5056364767 @default.
- W4308514422 hasAuthorship W4308514422A5061788478 @default.
- W4308514422 hasAuthorship W4308514422A5066456827 @default.
- W4308514422 hasAuthorship W4308514422A5071201906 @default.
- W4308514422 hasAuthorship W4308514422A5080953087 @default.
- W4308514422 hasAuthorship W4308514422A5085154532 @default.
- W4308514422 hasBestOaLocation W43085144221 @default.
- W4308514422 hasConcept C113246987 @default.
- W4308514422 hasConcept C142724271 @default.
- W4308514422 hasConcept C160539049 @default.
- W4308514422 hasConcept C170493617 @default.
- W4308514422 hasConcept C185592680 @default.
- W4308514422 hasConcept C202751555 @default.
- W4308514422 hasConcept C204787440 @default.
- W4308514422 hasConcept C2777899622 @default.
- W4308514422 hasConcept C2778423431 @default.
- W4308514422 hasConcept C2778790584 @default.
- W4308514422 hasConcept C2780527577 @default.
- W4308514422 hasConcept C55493867 @default.