Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308514616> ?p ?o ?g. }
- W4308514616 endingPage "111594" @default.
- W4308514616 startingPage "111594" @default.
- W4308514616 abstract "Obesity is detrimental to the immune system. It impairs lymphatics, T cell development, and lymphopoiesis; induces dysfunction of antitumor immunity; and also promotes tumor progression. However, direct evidence of the impact of obesity on viral infection is lacking. We report a protective role of obesity against herpes simplex virus 2 infection of the genital mucosa in mice. Although conventional antiviral immunity is comparable between obese mice and lean mice, obesity enhances the cytotoxic subset of γδ T cells. This effect is mediated by L-arginine produced by commensal microbiota in the genital mucosa, which induces pseudonormoxia of γδ T cells, resulting in increased natural killer (NK) group 2 D (NKG2D) expression of γδ T cells through the downregulation of hypoxia-inducible factor 1-alpha (HIF1A) by inducing nitric oxide (NO) production, thereby protecting mice from lethal genital herpes. Thus, our work illuminates one mechanism by which obesity-induced compositional changes in the vaginal microbiota can affect mucosal immune responses against viral infection." @default.
- W4308514616 created "2022-11-12" @default.
- W4308514616 creator A5005780547 @default.
- W4308514616 creator A5014530934 @default.
- W4308514616 creator A5031437702 @default.
- W4308514616 creator A5053431512 @default.
- W4308514616 creator A5074127978 @default.
- W4308514616 creator A5091444186 @default.
- W4308514616 date "2022-11-01" @default.
- W4308514616 modified "2023-10-14" @default.
- W4308514616 title "Obesity enhances antiviral immunity in the genital mucosa through a microbiota-mediated effect on γδ T cells" @default.
- W4308514616 cites W1797970090 @default.
- W4308514616 cites W1971669601 @default.
- W4308514616 cites W1973407294 @default.
- W4308514616 cites W2017046428 @default.
- W4308514616 cites W2022146147 @default.
- W4308514616 cites W2049374415 @default.
- W4308514616 cites W2054719244 @default.
- W4308514616 cites W2059790365 @default.
- W4308514616 cites W2062104381 @default.
- W4308514616 cites W2064975343 @default.
- W4308514616 cites W2067659428 @default.
- W4308514616 cites W2094978759 @default.
- W4308514616 cites W2096637604 @default.
- W4308514616 cites W2111967267 @default.
- W4308514616 cites W2115962454 @default.
- W4308514616 cites W2116218641 @default.
- W4308514616 cites W2137049999 @default.
- W4308514616 cites W2163304801 @default.
- W4308514616 cites W2263812771 @default.
- W4308514616 cites W2311480849 @default.
- W4308514616 cites W2402318213 @default.
- W4308514616 cites W2403657241 @default.
- W4308514616 cites W2473163213 @default.
- W4308514616 cites W2482434238 @default.
- W4308514616 cites W2482556255 @default.
- W4308514616 cites W2556403356 @default.
- W4308514616 cites W2563621526 @default.
- W4308514616 cites W2571049130 @default.
- W4308514616 cites W2752086275 @default.
- W4308514616 cites W2758759705 @default.
- W4308514616 cites W2763829062 @default.
- W4308514616 cites W2786546763 @default.
- W4308514616 cites W2792485109 @default.
- W4308514616 cites W2806887367 @default.
- W4308514616 cites W2899984019 @default.
- W4308514616 cites W2917520831 @default.
- W4308514616 cites W2956129408 @default.
- W4308514616 cites W3012957833 @default.
- W4308514616 cites W3019371629 @default.
- W4308514616 cites W3030942202 @default.
- W4308514616 cites W3033509943 @default.
- W4308514616 cites W3088648928 @default.
- W4308514616 cites W3093059312 @default.
- W4308514616 cites W3098348207 @default.
- W4308514616 cites W3098592536 @default.
- W4308514616 cites W3112898749 @default.
- W4308514616 cites W3128687890 @default.
- W4308514616 cites W3135560592 @default.
- W4308514616 cites W3138003073 @default.
- W4308514616 cites W3165379461 @default.
- W4308514616 cites W4286854662 @default.
- W4308514616 cites W4313331913 @default.
- W4308514616 doi "https://doi.org/10.1016/j.celrep.2022.111594" @default.
- W4308514616 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36351403" @default.
- W4308514616 hasPublicationYear "2022" @default.
- W4308514616 type Work @default.
- W4308514616 citedByCount "3" @default.
- W4308514616 countsByYear W43085146162023 @default.
- W4308514616 crossrefType "journal-article" @default.
- W4308514616 hasAuthorship W4308514616A5005780547 @default.
- W4308514616 hasAuthorship W4308514616A5014530934 @default.
- W4308514616 hasAuthorship W4308514616A5031437702 @default.
- W4308514616 hasAuthorship W4308514616A5053431512 @default.
- W4308514616 hasAuthorship W4308514616A5074127978 @default.
- W4308514616 hasAuthorship W4308514616A5091444186 @default.
- W4308514616 hasBestOaLocation W43085146161 @default.
- W4308514616 hasConcept C154317977 @default.
- W4308514616 hasConcept C202751555 @default.
- W4308514616 hasConcept C203014093 @default.
- W4308514616 hasConcept C2778867473 @default.
- W4308514616 hasConcept C2779341262 @default.
- W4308514616 hasConcept C55493867 @default.
- W4308514616 hasConcept C86803240 @default.
- W4308514616 hasConcept C8891405 @default.
- W4308514616 hasConceptScore W4308514616C154317977 @default.
- W4308514616 hasConceptScore W4308514616C202751555 @default.
- W4308514616 hasConceptScore W4308514616C203014093 @default.
- W4308514616 hasConceptScore W4308514616C2778867473 @default.
- W4308514616 hasConceptScore W4308514616C2779341262 @default.
- W4308514616 hasConceptScore W4308514616C55493867 @default.
- W4308514616 hasConceptScore W4308514616C86803240 @default.
- W4308514616 hasConceptScore W4308514616C8891405 @default.
- W4308514616 hasFunder F4320322030 @default.
- W4308514616 hasFunder F4320322120 @default.
- W4308514616 hasIssue "6" @default.
- W4308514616 hasLocation W43085146161 @default.
- W4308514616 hasLocation W43085146162 @default.