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- W4308515124 abstract "Steady-state extramedullary hematopoiesis during adulthood is an emerging field of great interest. The meninges contain both innate and adaptive immune cells, which provide immunosurveillance of the central nervous system (CNS). Hematopoietic progenitors that give rise to meningeal immune cells remain elusive. Here, we report that steady-state meninges of adult mice host hematopoietic stem cells (HSCs), as defined by long-term, efficient, multi-lineage reconstitution and self-renewal capacity in the meninges, blood, spleen, and bone marrow of sublethally irradiated adult recipients. HSCs lodge in the meninges after birth with local expression of pro-hematopoietic niche factors. Meningeal HSCs are locally maintained in homeostasis and get replenished from the blood only when the resident pool is reduced. With a tissue-specific expression profile, meningeal HSCs can provide the CNS with a constant supply of leukocytes more adapted to local microenvironment." @default.
- W4308515124 created "2022-11-12" @default.
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- W4308515124 date "2022-11-01" @default.
- W4308515124 modified "2023-10-17" @default.
- W4308515124 title "Identification of hematopoietic stem cells residing in the meninges of adult mice at steady state" @default.
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- W4308515124 doi "https://doi.org/10.1016/j.celrep.2022.111592" @default.
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