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- W4308522037 abstract "Glucosyltransferase enzymes (Gtfs) distribute among some streptococcal species in oral cavity and are known as key enzymes contributing to the development of oral biofilm such as dental plaque. In 18 streptococcal species, 45 glucosyltransferase genes (gtf) are detected from genome database. Gtfs catalyze the synthesis of the glucans, which are polymers of glucose, from sucrose and they are main component of oral biofilm. Especially, the Gtfs from Streptococcus mutans are recognized as one of dental caries pathogens since they contribute to the formation of dental plaque and the establishment of S. mutans in the tooth surface. Therefore, Gtfs has been studied particularly by many researchers in the dentistry field to develop the anti- caries vaccine. However, it is not still accomplished. In these days, the phylogenetic and crystal structure analyses of Gtfs were performed and the study of Gtfs will enter new situation from the technique in the past old viewpoint. The findings from those analyses will affect the development of the anti-caries vaccine very much after this. In this review, we summarize the findings of oral streptococcal Gtfs and consider the perspectives of the dental caries prevention which targeted Gtf." @default.
- W4308522037 created "2022-11-12" @default.
- W4308522037 creator A5032603825 @default.
- W4308522037 creator A5050387199 @default.
- W4308522037 date "2022-11-01" @default.
- W4308522037 modified "2023-10-17" @default.
- W4308522037 title "The findings of glucosyltransferase enzymes derived from oral streptococci" @default.
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- W4308522037 doi "https://doi.org/10.1016/j.jdsr.2022.10.003" @default.
- W4308522037 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36340584" @default.
- W4308522037 hasPublicationYear "2022" @default.
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