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- W4308531593 abstract "Pyrethroids are widely applied insecticides in agriculture, but their frequent use has provoked many cases of resistance, in which mutations in the voltage-gated sodium channel (VGSC), the pyrethroid target-site, were shown to play a major role. However, for the spider mite Tetranychus urticae, it has also been shown that increased detoxification contributes to resistance against the pyrethroid bifenthrin. Here, we performed QTL-mapping to identify the genomic loci underlying bifenthrin resistance in T. urticae. Two loci on chromosome 1 were identified, with the VGSC gene being located near the second QTL and harboring the well-known L1024V mutation. In addition, the presence of an L925M mutation in the VGSC of a highly bifenthrin-resistant strain and its loss in its derived, susceptible, inbred line indicated the importance of target-site mutations in bifenthrin resistance. Further, RNAseq experiments revealed that genes encoding detoxification enzymes, including carboxyl/choline esterases (CCEs), cytochrome P450 monooxygenases and UDP-glycosyl transferases (UGTs), were overexpressed in resistant strains. Toxicity bioassays with bifenthrin (ester pyrethroid) and etofenprox (non-ester pyrethroid) also indicated a possible role for CCEs in bifenthrin resistance. A selection of CCEs and UGTs were therefore functionally expressed, and CCEinc18 was shown to metabolize bifenthrin, while teturUGT10 could glycosylate bifenthrin-alcohol. To conclude, our findings suggest that both target-site and metabolic mechanisms underlie bifenthrin resistance in T. urticae, and these might synergize high levels of resistance." @default.
- W4308531593 created "2022-11-12" @default.
- W4308531593 creator A5009720750 @default.
- W4308531593 creator A5033365156 @default.
- W4308531593 creator A5044768221 @default.
- W4308531593 creator A5063389950 @default.
- W4308531593 creator A5069399423 @default.
- W4308531593 creator A5084225729 @default.
- W4308531593 date "2022-11-07" @default.
- W4308531593 modified "2023-10-16" @default.
- W4308531593 title "High-Resolution Genetic Mapping Combined with Transcriptome Profiling Reveals That Both Target-Site Resistance and Increased Detoxification Confer Resistance to the Pyrethroid Bifenthrin in the Spider Mite Tetranychus urticae" @default.
- W4308531593 cites W12955688 @default.
- W4308531593 cites W1483201630 @default.
- W4308531593 cites W1545244317 @default.
- W4308531593 cites W1847862900 @default.
- W4308531593 cites W1919257374 @default.
- W4308531593 cites W1972210355 @default.
- W4308531593 cites W1972528017 @default.
- W4308531593 cites W1982107364 @default.
- W4308531593 cites W1984259930 @default.
- W4308531593 cites W1989539861 @default.
- W4308531593 cites W1994017019 @default.
- W4308531593 cites W1996330645 @default.
- W4308531593 cites W1998470163 @default.
- W4308531593 cites W2003809784 @default.
- W4308531593 cites W2006252642 @default.
- W4308531593 cites W2010969866 @default.
- W4308531593 cites W2014741826 @default.
- W4308531593 cites W2019649325 @default.
- W4308531593 cites W2021341670 @default.
- W4308531593 cites W2023270829 @default.
- W4308531593 cites W2024057982 @default.
- W4308531593 cites W2024086677 @default.
- W4308531593 cites W2025203003 @default.
- W4308531593 cites W2027017286 @default.
- W4308531593 cites W2028757059 @default.
- W4308531593 cites W2029641872 @default.
- W4308531593 cites W2030360502 @default.
- W4308531593 cites W2034891952 @default.
- W4308531593 cites W2038905035 @default.
- W4308531593 cites W2043808419 @default.
- W4308531593 cites W2048887200 @default.
- W4308531593 cites W2050208773 @default.
- W4308531593 cites W2063125213 @default.
- W4308531593 cites W2067298118 @default.
- W4308531593 cites W2067786443 @default.
- W4308531593 cites W2074903656 @default.
- W4308531593 cites W2077986322 @default.
- W4308531593 cites W2090878969 @default.
- W4308531593 cites W2094751524 @default.
- W4308531593 cites W2096549168 @default.
- W4308531593 cites W2103161948 @default.
- W4308531593 cites W2103441770 @default.
- W4308531593 cites W2104941434 @default.
- W4308531593 cites W2106578986 @default.
- W4308531593 cites W2108234281 @default.
- W4308531593 cites W2112143233 @default.
- W4308531593 cites W2128635872 @default.
- W4308531593 cites W2129611319 @default.
- W4308531593 cites W2134526812 @default.
- W4308531593 cites W2156601092 @default.
- W4308531593 cites W2164731600 @default.
- W4308531593 cites W2166537326 @default.
- W4308531593 cites W2169456326 @default.
- W4308531593 cites W2179438025 @default.
- W4308531593 cites W2225838195 @default.
- W4308531593 cites W2300141009 @default.
- W4308531593 cites W2332867280 @default.
- W4308531593 cites W2408734345 @default.
- W4308531593 cites W2411397641 @default.
- W4308531593 cites W2496825005 @default.
- W4308531593 cites W2543362609 @default.
- W4308531593 cites W2568328160 @default.
- W4308531593 cites W2733664608 @default.
- W4308531593 cites W2746899921 @default.
- W4308531593 cites W2756322811 @default.
- W4308531593 cites W2769043861 @default.
- W4308531593 cites W2770086359 @default.
- W4308531593 cites W2795348572 @default.
- W4308531593 cites W2805717664 @default.
- W4308531593 cites W2810473995 @default.
- W4308531593 cites W2896720934 @default.
- W4308531593 cites W2897814436 @default.
- W4308531593 cites W2900991893 @default.
- W4308531593 cites W2904015612 @default.
- W4308531593 cites W2921497123 @default.
- W4308531593 cites W2922884849 @default.
- W4308531593 cites W2926046099 @default.
- W4308531593 cites W2936493110 @default.
- W4308531593 cites W2940561751 @default.
- W4308531593 cites W2954065688 @default.
- W4308531593 cites W2968104964 @default.
- W4308531593 cites W2968984052 @default.
- W4308531593 cites W2977471115 @default.
- W4308531593 cites W2995628473 @default.
- W4308531593 cites W2997624703 @default.
- W4308531593 cites W3008440957 @default.
- W4308531593 cites W3014417368 @default.