Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308531836> ?p ?o ?g. }
- W4308531836 abstract "Abstract Metastasis is the leading cause of death in colorectal cancer (CRC) patients, and the liver is the most common site of metastasis. Tumor cell metastasis can be thought of as an invasion-metastasis cascade and metastatic organotropism is thought to be a process that relies on the intrinsic properties of tumor cells and their interactions with molecules and cells in the microenvironment. Many studies have provided new insights into the molecular mechanism and contributing factors involved in CRC liver metastasis for a better understanding of the organ-specific metastasis process. The purpose of this review is to summarize the theories that explain CRC liver metastasis at multiple molecular dimensions (including genetic and non-genetic factors), as well as the main factors that cause CRC liver metastasis. Many findings suggest that metastasis may occur earlier than expected and with specific organ-anchoring property. The emergence of potential metastatic clones, the timing of dissemination, and the distinct routes of metastasis have been explained by genomic studies. The main force of CRC liver metastasis is also thought to be epigenetic alterations and dynamic phenotypic traits. Furthermore, we review key extrinsic factors that influence CRC cell metastasis and liver tropisms, such as pre-niches, tumor stromal cells, adhesion molecules, and immune/inflammatory responses in the tumor microenvironment. In addition, biomarkers associated with early diagnosis, prognosis, and recurrence of liver metastasis from CRC are summarized to enlighten potential clinical practice, including some markers that can be used as therapeutic targets to provide new perspectives for the treatment strategies of CRC liver metastasis." @default.
- W4308531836 created "2022-11-12" @default.
- W4308531836 creator A5037865142 @default.
- W4308531836 creator A5038029802 @default.
- W4308531836 creator A5048141581 @default.
- W4308531836 creator A5078383812 @default.
- W4308531836 date "2022-11-08" @default.
- W4308531836 modified "2023-10-01" @default.
- W4308531836 title "Intracellular and extracellular factors of colorectal cancer liver metastasis: a pivotal perplex to be fully elucidated" @default.
- W4308531836 cites W1524174101 @default.
- W4308531836 cites W1830146239 @default.
- W4308531836 cites W1918975836 @default.
- W4308531836 cites W1950118853 @default.
- W4308531836 cites W1969510453 @default.
- W4308531836 cites W1975476791 @default.
- W4308531836 cites W1983567075 @default.
- W4308531836 cites W2003605266 @default.
- W4308531836 cites W2010873488 @default.
- W4308531836 cites W2012282774 @default.
- W4308531836 cites W2020406481 @default.
- W4308531836 cites W2027775756 @default.
- W4308531836 cites W2034580741 @default.
- W4308531836 cites W2043772256 @default.
- W4308531836 cites W2056331233 @default.
- W4308531836 cites W2062889854 @default.
- W4308531836 cites W2064634303 @default.
- W4308531836 cites W2080232352 @default.
- W4308531836 cites W2085709573 @default.
- W4308531836 cites W2092180337 @default.
- W4308531836 cites W2097409670 @default.
- W4308531836 cites W2097862336 @default.
- W4308531836 cites W2110190175 @default.
- W4308531836 cites W2112836053 @default.
- W4308531836 cites W2117692326 @default.
- W4308531836 cites W2132966617 @default.
- W4308531836 cites W2135163856 @default.
- W4308531836 cites W2145990138 @default.
- W4308531836 cites W2157910818 @default.
- W4308531836 cites W2257271955 @default.
- W4308531836 cites W2315243978 @default.
- W4308531836 cites W2465067923 @default.
- W4308531836 cites W2470172036 @default.
- W4308531836 cites W2533419167 @default.
- W4308531836 cites W2560375214 @default.
- W4308531836 cites W2570608016 @default.
- W4308531836 cites W2573970795 @default.
- W4308531836 cites W2576118052 @default.
- W4308531836 cites W2590240215 @default.
- W4308531836 cites W2598830924 @default.
- W4308531836 cites W2605215962 @default.
- W4308531836 cites W2608625783 @default.
- W4308531836 cites W2618389271 @default.
- W4308531836 cites W2626568439 @default.
- W4308531836 cites W2727696001 @default.
- W4308531836 cites W2745920200 @default.
- W4308531836 cites W2754299785 @default.
- W4308531836 cites W2760216793 @default.
- W4308531836 cites W2763367287 @default.
- W4308531836 cites W2766139357 @default.
- W4308531836 cites W2767311920 @default.
- W4308531836 cites W2783615853 @default.
- W4308531836 cites W2789078890 @default.
- W4308531836 cites W2789886541 @default.
- W4308531836 cites W2789902689 @default.
- W4308531836 cites W2810314936 @default.
- W4308531836 cites W2811238204 @default.
- W4308531836 cites W2884909224 @default.
- W4308531836 cites W2885323958 @default.
- W4308531836 cites W2893282093 @default.
- W4308531836 cites W2906427523 @default.
- W4308531836 cites W2909089746 @default.
- W4308531836 cites W2912532051 @default.
- W4308531836 cites W2944031662 @default.
- W4308531836 cites W2947891482 @default.
- W4308531836 cites W2953576767 @default.
- W4308531836 cites W2954113338 @default.
- W4308531836 cites W2959909875 @default.
- W4308531836 cites W2962445025 @default.
- W4308531836 cites W2970819265 @default.
- W4308531836 cites W2973337846 @default.
- W4308531836 cites W2974072826 @default.
- W4308531836 cites W2975954696 @default.
- W4308531836 cites W2979941222 @default.
- W4308531836 cites W2981014677 @default.
- W4308531836 cites W2981461005 @default.
- W4308531836 cites W2981548686 @default.
- W4308531836 cites W2992640343 @default.
- W4308531836 cites W2992997309 @default.
- W4308531836 cites W2996435406 @default.
- W4308531836 cites W2997492439 @default.
- W4308531836 cites W2998673845 @default.
- W4308531836 cites W2999168532 @default.
- W4308531836 cites W3000166603 @default.
- W4308531836 cites W3000635792 @default.
- W4308531836 cites W3000669373 @default.
- W4308531836 cites W3001007396 @default.
- W4308531836 cites W3005078544 @default.
- W4308531836 cites W3005992207 @default.
- W4308531836 cites W3008416036 @default.
- W4308531836 cites W3010006672 @default.