FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308537547> ?p ?o ?g. }

• W4308537547 endingPage "186" @default.
• W4308537547 startingPage "167" @default.
• W4308537547 abstract "Abstract Hereditary hemorrhagic telangiectasia (HHT) is a genetic vascular disorder characterized by the presence of arteriovenous malformation (AVM) in multiple organs. HHT is caused by mutations in genes encoding major constituents for transforming growth factor-β (TGF-β) family signaling: endoglin (ENG), activin receptor-like kinase 1 (ALK1), and SMAD4. The identity of physiological ligands for this ENG-ALK1 signaling pertinent to AVM formation has yet to be clearly determined. To investigate whether bone morphogenetic protein 9 (BMP9), BMP10, or both are physiological ligands of ENG-ALK1 signaling involved in arteriovenous network formation, we generated a novel Bmp10 conditional knockout mouse strain. We examined whether global Bmp10 -inducible knockout (iKO) mice develop AVMs at neonatal and adult stages in comparison with control, Bmp9 -KO, and Bmp9/10 -double KO (dKO) mice. Bmp10 -iKO and Bmp9/10 -dKO mice showed AVMs in developing retina, postnatal brain, and adult wounded skin, while Bmp9 -KO did not display any noticeable vascular defects. Bmp10 deficiency resulted in increased proliferation and size of endothelial cells in AVM vessels. The impaired neurovascular integrity in the brain and retina of Bmp10 -iKO and Bmp9/10 -dKO mice was detected. Bmp9/10 -dKO mice exhibited the lethality and vascular malformation similar to Bmp10 -iKO mice, but their phenotypes were more pronounced. Administration of BMP10 protein, but not BMP9 protein, prevented retinal AVM in Bmp9/10 -dKO and endothelial-specific Eng -iKO mice. These data indicate that BMP10 is indispensable for the development of a proper arteriovenous network, whereas BMP9 has limited compensatory functions for the loss of BMP10. We suggest that BMP10 is the most relevant physiological ligand of the ENG-ALK1 signaling pathway pertinent to HHT pathogenesis." @default.
• W4308537547 created "2022-11-12" @default.
• W4308537547 creator A5012967178 @default.
• W4308537547 creator A5027154926 @default.
• W4308537547 creator A5035674745 @default.
• W4308537547 creator A5054683824 @default.
• W4308537547 creator A5088415739 @default.
• W4308537547 creator A5091174671 @default.
• W4308537547 date "2022-11-08" @default.
• W4308537547 modified "2023-10-14" @default.
• W4308537547 title "BMP10 functions independently from BMP9 for the development of a proper arteriovenous network" @default.
• W4308537547 cites W1657646300 @default.
• W4308537547 cites W1970122794 @default.
• W4308537547 cites W1981358858 @default.
• W4308537547 cites W2002569536 @default.
• W4308537547 cites W2013933388 @default.
• W4308537547 cites W2019453487 @default.
• W4308537547 cites W2026105859 @default.
• W4308537547 cites W2027760929 @default.
• W4308537547 cites W2029918174 @default.
• W4308537547 cites W2035282407 @default.
• W4308537547 cites W2037590098 @default.
• W4308537547 cites W2045285970 @default.
• W4308537547 cites W2060372234 @default.
• W4308537547 cites W2070755192 @default.
• W4308537547 cites W2075998623 @default.
• W4308537547 cites W2087323994 @default.
• W4308537547 cites W2093316809 @default.
• W4308537547 cites W2109947902 @default.
• W4308537547 cites W2111336754 @default.
• W4308537547 cites W2115581142 @default.
• W4308537547 cites W2127551299 @default.
• W4308537547 cites W2131246162 @default.
• W4308537547 cites W2143267806 @default.
• W4308537547 cites W2146646972 @default.
• W4308537547 cites W2148181313 @default.
• W4308537547 cites W2153738160 @default.
• W4308537547 cites W2154799239 @default.
• W4308537547 cites W2158847377 @default.
• W4308537547 cites W2160489211 @default.
• W4308537547 cites W2523446095 @default.
• W4308537547 cites W2557883191 @default.
• W4308537547 cites W2619222934 @default.
• W4308537547 cites W2619574793 @default.
• W4308537547 cites W2619679718 @default.
• W4308537547 cites W2770216137 @default.
• W4308537547 cites W2794435480 @default.
• W4308537547 cites W2803631435 @default.
• W4308537547 cites W2818354613 @default.
• W4308537547 cites W2889160297 @default.
• W4308537547 cites W2899792317 @default.
• W4308537547 cites W2953193069 @default.
• W4308537547 cites W2986360374 @default.
• W4308537547 cites W2996287339 @default.
• W4308537547 cites W3012616341 @default.
• W4308537547 cites W3046695108 @default.
• W4308537547 cites W3112336727 @default.
• W4308537547 cites W3121679335 @default.
• W4308537547 cites W3165589439 @default.
• W4308537547 cites W4200165304 @default.
• W4308537547 cites W4210412627 @default.
• W4308537547 doi "https://doi.org/10.1007/s10456-022-09859-0" @default.
• W4308537547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36348215" @default.
• W4308537547 hasPublicationYear "2022" @default.
• W4308537547 type Work @default.
• W4308537547 citedByCount "4" @default.
• W4308537547 countsByYear W43085375472023 @default.
• W4308537547 crossrefType "journal-article" @default.
• W4308537547 hasAuthorship W4308537547A5012967178 @default.
• W4308537547 hasAuthorship W4308537547A5027154926 @default.
• W4308537547 hasAuthorship W4308537547A5035674745 @default.
• W4308537547 hasAuthorship W4308537547A5054683824 @default.
• W4308537547 hasAuthorship W4308537547A5088415739 @default.
• W4308537547 hasAuthorship W4308537547A5091174671 @default.
• W4308537547 hasBestOaLocation W43085375471 @default.
• W4308537547 hasConcept C10205521 @default.
• W4308537547 hasConcept C104317684 @default.
• W4308537547 hasConcept C105702510 @default.
• W4308537547 hasConcept C126322002 @default.
• W4308537547 hasConcept C127716648 @default.
• W4308537547 hasConcept C134018914 @default.
• W4308537547 hasConcept C164659718 @default.
• W4308537547 hasConcept C2780394083 @default.
• W4308537547 hasConcept C28328180 @default.
• W4308537547 hasConcept C31507581 @default.
• W4308537547 hasConcept C54355233 @default.
• W4308537547 hasConcept C6061869 @default.
• W4308537547 hasConcept C71924100 @default.
• W4308537547 hasConcept C86803240 @default.
• W4308537547 hasConcept C95444343 @default.
• W4308537547 hasConceptScore W4308537547C10205521 @default.
• W4308537547 hasConceptScore W4308537547C104317684 @default.
• W4308537547 hasConceptScore W4308537547C105702510 @default.
• W4308537547 hasConceptScore W4308537547C126322002 @default.
• W4308537547 hasConceptScore W4308537547C127716648 @default.
• W4308537547 hasConceptScore W4308537547C134018914 @default.
• W4308537547 hasConceptScore W4308537547C164659718 @default.
• W4308537547 hasConceptScore W4308537547C2780394083 @default.

• next