FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308541708> ?p ?o ?g. }

• W4308541708 endingPage "118235" @default.
• W4308541708 startingPage "118235" @default.
• W4308541708 abstract "• A novel micro-analytical device based on using a spinning spiral microchannel is proposed and analysed. • A model is developed, giving a quantitative prediction of flow and cells separation inside the channel. • The separation of human breast cancer cells from a blood sample has been investigated over a wide range of volume flow rates (100–1000 ml/h) and rotation rates (0–200 rpm). • Different than the conventional approaches, the strength and structure of the generated Corilois motions can be adjusted, achieving both higher throughput and complete separation of the cancerous cells. Cancer cells can detach from their original place and travel through tiny blood vessels or lymphatic capillaries in nearby tissues, forming a new tumour in other places of the body. While these circulating tumour cells (CTCs) are usually few in relation to the native blood cells, they provide crucial information about the characteristics of the primary tumour. Therefore, detecting and separating such cells from the bloodstream is an essential step in terms of diagnosis, treatment and prognosis of cancer patients. Perhaps, one of the well-known methods of separating CTCs is inertial focusing using a curved microchannel. This approach leaves CTCs separation strongly dependant on the channel design and Reynolds number for a given sample’s properties. Thus, the design suitable for a certain sample does not necessarily suit others. Here, a novel micro-analytical device is proposed and analysed. The device is based on using a spiral microchannel spinning around its axis at low rotation speed. The rotation generates Corilois secondary motions, focusing the separation of CTCs. The strength and structure of these Corilois motions can be adjusted easily by changing the rotation rate, which is under external control. This opens up the possibility of handling samples with different properties, achieving both higher throughput and complete separation of CTCs. The present work demonstrates the separation of human breast cancer cells using this approach over a wide range of volume flow rates (100–1000 ml/h) at different rotation rates (0–200 rpm), operating at relatively moderate Reynolds number. A model is developed, giving a quantitative prediction of flow and cells separation. It is shown that, for a single design, the cancer cells can be sorted completely with 100 % purity over a wide range of flow rates (400–700 ml/h) with a small adjustment of the rotation rate." @default.
• W4308541708 created "2022-11-12" @default.
• W4308541708 creator A5026242634 @default.
• W4308541708 date "2023-01-01" @default.
• W4308541708 modified "2023-10-17" @default.
• W4308541708 title "Analysis of circulating tumour cells separation in a curved microchannel under a high gravitational field" @default.
• W4308541708 cites W1902700006 @default.
• W4308541708 cites W1982760718 @default.
• W4308541708 cites W1985972457 @default.
• W4308541708 cites W2000108132 @default.
• W4308541708 cites W2006197460 @default.
• W4308541708 cites W2011034691 @default.
• W4308541708 cites W2011777307 @default.
• W4308541708 cites W2015123968 @default.
• W4308541708 cites W2030593367 @default.
• W4308541708 cites W2043639266 @default.
• W4308541708 cites W2047654096 @default.
• W4308541708 cites W2048597124 @default.
• W4308541708 cites W2062764532 @default.
• W4308541708 cites W2065616109 @default.
• W4308541708 cites W2066149364 @default.
• W4308541708 cites W2067691716 @default.
• W4308541708 cites W2068197820 @default.
• W4308541708 cites W2079868275 @default.
• W4308541708 cites W2091101269 @default.
• W4308541708 cites W2093921289 @default.
• W4308541708 cites W2094049599 @default.
• W4308541708 cites W2097950721 @default.
• W4308541708 cites W2102864709 @default.
• W4308541708 cites W2113430850 @default.
• W4308541708 cites W2115158793 @default.
• W4308541708 cites W2119231508 @default.
• W4308541708 cites W2132045732 @default.
• W4308541708 cites W2137310694 @default.
• W4308541708 cites W2146160500 @default.
• W4308541708 cites W2162444401 @default.
• W4308541708 cites W2168705567 @default.
• W4308541708 cites W2186711617 @default.
• W4308541708 cites W2316158997 @default.
• W4308541708 cites W2507915407 @default.
• W4308541708 cites W2621788387 @default.
• W4308541708 cites W2641809654 @default.
• W4308541708 cites W2738538457 @default.
• W4308541708 cites W2745182946 @default.
• W4308541708 cites W2765562305 @default.
• W4308541708 cites W2766098019 @default.
• W4308541708 cites W2770489456 @default.
• W4308541708 cites W2780558037 @default.
• W4308541708 cites W2790833194 @default.
• W4308541708 cites W2790914328 @default.
• W4308541708 cites W2796088947 @default.
• W4308541708 cites W2899428728 @default.
• W4308541708 cites W2908385992 @default.
• W4308541708 cites W2911482083 @default.
• W4308541708 cites W2913006108 @default.
• W4308541708 cites W2916158161 @default.
• W4308541708 cites W2948469874 @default.
• W4308541708 cites W2972403309 @default.
• W4308541708 cites W2995174008 @default.
• W4308541708 cites W3018919319 @default.
• W4308541708 cites W3083603772 @default.
• W4308541708 cites W3084134827 @default.
• W4308541708 doi "https://doi.org/10.1016/j.ces.2022.118235" @default.
• W4308541708 hasPublicationYear "2023" @default.
• W4308541708 type Work @default.
• W4308541708 citedByCount "2" @default.
• W4308541708 countsByYear W43085417082023 @default.
• W4308541708 crossrefType "journal-article" @default.
• W4308541708 hasAuthorship W4308541708A5026242634 @default.
• W4308541708 hasConcept C121332964 @default.
• W4308541708 hasConcept C121608353 @default.
• W4308541708 hasConcept C126322002 @default.
• W4308541708 hasConcept C127413603 @default.
• W4308541708 hasConcept C136229726 @default.
• W4308541708 hasConcept C154815118 @default.
• W4308541708 hasConcept C154945302 @default.
• W4308541708 hasConcept C159985019 @default.
• W4308541708 hasConcept C171250308 @default.
• W4308541708 hasConcept C174128100 @default.
• W4308541708 hasConcept C182748727 @default.
• W4308541708 hasConcept C185592680 @default.
• W4308541708 hasConcept C192562407 @default.
• W4308541708 hasConcept C196558001 @default.
• W4308541708 hasConcept C198531522 @default.
• W4308541708 hasConcept C2779013556 @default.
• W4308541708 hasConcept C41008148 @default.
• W4308541708 hasConcept C43617362 @default.
• W4308541708 hasConcept C57879066 @default.
• W4308541708 hasConcept C61238886 @default.
• W4308541708 hasConcept C63662833 @default.
• W4308541708 hasConcept C71924100 @default.
• W4308541708 hasConcept C74050887 @default.
• W4308541708 hasConcept C78519656 @default.
• W4308541708 hasConcept C8673954 @default.
• W4308541708 hasConcept C96232424 @default.
• W4308541708 hasConceptScore W4308541708C121332964 @default.
• W4308541708 hasConceptScore W4308541708C121608353 @default.
• W4308541708 hasConceptScore W4308541708C126322002 @default.

• next