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• W4308549916 abstract "Tryptophan is a functional amino acid. This study aimed to investigate whether dietary tryptophan supplementation can alleviate Escherichia coli lipopolysaccharide (LPS)-induced skeletal muscle fiber transition from type I to type II in pigs, and the molecular mechanism was also examined. Eighteen weaned piglets were allotted to three treatments groups, namely, the nonchallenged control, LPS-challenged control and LPS + 0.2% tryptophan groups. On day 35, the pigs in the LPS and LPS + 0.2% tryptophan groups were challenged by injection with 100 μg/kg body weight (BW) LPS, whereas the control group was given sterile saline. Tryptophan can attenuate LPS-induced decrease in protein content of slow MyHC, the activities of succinic dehydrogenase, malate dehydrogenase (MDH) and antioxidant enzyme, the mRNA expression of oxidative muscle fiber-related genes, type I fiber proportion, and increase in lactate dehydrogenase (LDH) activity, the mRNA expression level of MyHC IIb and type II fiber proportion. Moreover, tryptophan supplementation attenuated LPS-induced decrease in the expression levels of phosphorylated AMP-activated protein kinase (AMPK), silent information regulator 1 (Sirt1) and peroxisome proliferator activated receptor gamma coactivator 1-alpha (PGC-1α). Collectively, tryptophan can alleviate LPS-induced muscle fiber type transformation from type I to type II. This effect is associated with activating the Sirt1/AMPK/PGC-1α signaling pathway." @default.
• W4308549916 created "2022-11-12" @default.
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• W4308549916 date "2022-11-08" @default.
• W4308549916 modified "2023-09-29" @default.
• W4308549916 title "Tryptophan alleviates lipopolysaccharide-induced muscle fiber type transformation from type I to II and modulates Sirt1/AMPK/PGC-1α signaling pathway in pigs" @default.
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• W4308549916 doi "https://doi.org/10.1080/10495398.2022.2136679" @default.
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