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- W4308552662 abstract "Aim: Gastric cancer (GC) is the leading cause of cancer death, and is associated with host genetic factors. This study aimed to determine the impact of SP4 polymorphisms on GC. Materials & methods: Four hundred and eighty-nine GC patients and 481 healthy subjects were recruited. The association between single nucleotide polymorphisms and GC risk was investigated by logistic regression analysis. Results: It was observed that rs39302 and rs7811417 were related to a decreased GC risk. Stratified analyses showed that rs39302 decreased GC susceptibility at ages ≤60 years, in men, GC patients who had previously smoked and drank. rs7811417 had a risk-decreasing impact on the patients aged ≤60 years, in men, GC patients who were nonsmoking and nondrinking. rs35929923 decreased the GC risk of patients in grade III-IV and the lymph node metastasis subgroup. Conclusion:SP4 gene polymorphisms are associated with GC risk." @default.
- W4308552662 created "2022-11-12" @default.
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- W4308552662 date "2022-11-01" @default.
- W4308552662 modified "2023-10-14" @default.
- W4308552662 title "The genetic polymorphisms in the <i>SP4</i> gene and the risk of gastric cancer" @default.
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- W4308552662 doi "https://doi.org/10.2217/fon-2022-0577" @default.
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