Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308557172> ?p ?o ?g. }
- W4308557172 endingPage "2603" @default.
- W4308557172 startingPage "2591" @default.
- W4308557172 abstract "In recent years, increasing evidence has shown that the gut microbiota and their metabolites play a pivotal role in human health and diseases, especially the cardiovascular diseases (CVDs). Intestinal flora imbalance (changes in the composition and function of intestinal flora) accelerates the progression of CVDs. The intestinal flora breaks down the food ingested by the host into a series of metabolically active products, including trimethylamine N-Oxide (TMAO), short-chain fatty acids (SCFAs), primary and secondary bile acids, tryptophan and indole derivatives, phenylacetylglutamine (PAGln) and branched chain amino acids (BCAA). These metabolites participate in the occurrence and development of CVDs via abnormally activating these signaling pathways more swiftly when the gut barrier integrity is broken down. This review focuses on the production and metabolism of TMAO and SCFAs. At the same time, we summarize the roles of intestinal flora metabolites in the occurrence and development of coronary heart disease and hypertension, pulmonary hypertension and other CVDs. The theories of gut-lung axis and gut-heart axis are provided, aiming to explore the potential targets for the treatment of CVDs based on the roles of the intestinal flora in the CVDs." @default.
- W4308557172 created "2022-11-12" @default.
- W4308557172 creator A5008471779 @default.
- W4308557172 creator A5019825002 @default.
- W4308557172 creator A5039600403 @default.
- W4308557172 creator A5042261919 @default.
- W4308557172 creator A5048938906 @default.
- W4308557172 creator A5075675128 @default.
- W4308557172 creator A5081837712 @default.
- W4308557172 creator A5089934160 @default.
- W4308557172 date "2022-11-01" @default.
- W4308557172 modified "2023-09-30" @default.
- W4308557172 title "Intestinal Flora Derived Metabolites Affect the Occurrence and Development of Cardiovascular Disease" @default.
- W4308557172 cites W1420654867 @default.
- W4308557172 cites W1502231121 @default.
- W4308557172 cites W1568818630 @default.
- W4308557172 cites W1617526274 @default.
- W4308557172 cites W1689013859 @default.
- W4308557172 cites W1783924004 @default.
- W4308557172 cites W1919067548 @default.
- W4308557172 cites W1980867561 @default.
- W4308557172 cites W1994863439 @default.
- W4308557172 cites W2000204073 @default.
- W4308557172 cites W2005964305 @default.
- W4308557172 cites W2019630820 @default.
- W4308557172 cites W2035421462 @default.
- W4308557172 cites W2039822562 @default.
- W4308557172 cites W2039907390 @default.
- W4308557172 cites W2046971089 @default.
- W4308557172 cites W2049977216 @default.
- W4308557172 cites W2053274749 @default.
- W4308557172 cites W2060185417 @default.
- W4308557172 cites W2066410861 @default.
- W4308557172 cites W2078599166 @default.
- W4308557172 cites W2106515170 @default.
- W4308557172 cites W2111157610 @default.
- W4308557172 cites W2115944543 @default.
- W4308557172 cites W2124507080 @default.
- W4308557172 cites W2125826054 @default.
- W4308557172 cites W2136344314 @default.
- W4308557172 cites W2150350691 @default.
- W4308557172 cites W2166168078 @default.
- W4308557172 cites W2168987491 @default.
- W4308557172 cites W2169330513 @default.
- W4308557172 cites W2183520340 @default.
- W4308557172 cites W2207436601 @default.
- W4308557172 cites W2254642444 @default.
- W4308557172 cites W2288501492 @default.
- W4308557172 cites W2295882128 @default.
- W4308557172 cites W2316224242 @default.
- W4308557172 cites W2342171400 @default.
- W4308557172 cites W2394839507 @default.
- W4308557172 cites W2477547149 @default.
- W4308557172 cites W2509978915 @default.
- W4308557172 cites W2532681266 @default.
- W4308557172 cites W2538004187 @default.
- W4308557172 cites W2594994892 @default.
- W4308557172 cites W2595826119 @default.
- W4308557172 cites W2611324209 @default.
- W4308557172 cites W2614578122 @default.
- W4308557172 cites W2729826858 @default.
- W4308557172 cites W2732316158 @default.
- W4308557172 cites W2757397722 @default.
- W4308557172 cites W2769145826 @default.
- W4308557172 cites W2780050042 @default.
- W4308557172 cites W2802989498 @default.
- W4308557172 cites W2807728333 @default.
- W4308557172 cites W2888613389 @default.
- W4308557172 cites W2888902236 @default.
- W4308557172 cites W2900220483 @default.
- W4308557172 cites W2903852521 @default.
- W4308557172 cites W2908210684 @default.
- W4308557172 cites W2909870178 @default.
- W4308557172 cites W2940380744 @default.
- W4308557172 cites W2947182993 @default.
- W4308557172 cites W2947635464 @default.
- W4308557172 cites W2949820012 @default.
- W4308557172 cites W2972562807 @default.
- W4308557172 cites W2972646943 @default.
- W4308557172 cites W2980592165 @default.
- W4308557172 cites W2981499784 @default.
- W4308557172 cites W2990595854 @default.
- W4308557172 cites W2995711111 @default.
- W4308557172 cites W2998192472 @default.
- W4308557172 cites W3007757041 @default.
- W4308557172 cites W3008932987 @default.
- W4308557172 cites W3009682272 @default.
- W4308557172 cites W3010928772 @default.
- W4308557172 cites W3013143414 @default.
- W4308557172 cites W3019198684 @default.
- W4308557172 cites W3022229857 @default.
- W4308557172 cites W3048455630 @default.
- W4308557172 cites W3048670441 @default.
- W4308557172 cites W3049569614 @default.
- W4308557172 cites W3089112777 @default.
- W4308557172 cites W3090080032 @default.
- W4308557172 cites W3093717227 @default.
- W4308557172 cites W3111069425 @default.