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• W4308558708 abstract "Chronic lymphocytic leukemia (CLL) is a heterogeneous disease, whose presentation and clinical course are highly variable. Identification of novel prognostic factors may contribute to improving the CLL classification and providing indications for treatment options. The zinc finger protein ZNF224 plays a key role in cell transformation, through the control of apoptotic and survival pathways. In this study, we evaluated the potential application of ZNF224 as a novel marker of CLL progression and therapy responsiveness. To this aim, we analyzed ZNF224 expression levels in B lymphocytes from CLL patients at different stages of the disease and in patients showing different treatment outcomes. The expression of ZNF224 was significantly increased in disease progression and dramatically decreased in patients in complete remission after chemotherapy. Gene expression correlation analysis performed on datasets of CLL patients revealed that ZNF224 expression was well correlated with that of some prognostic and predictive markers. Moreover, bioinformatic analysis coupled ZNF224 to NF-κB pathway, and experimental data demonstrated that RNA interference of ZNF224 reduced the activity of the NF-κB survival pathway in CLL cells. Consistently with a pro-survival role, ZNF224 knockdown raised spontaneous and drug-induced apoptosis and inhibited the proliferation of peripheral blood mononuclear cells from CLL patients. Our findings provide evidence for the involvement of ZNF224 in the survival of CLL cells via NF-κB pathway modulation, and also suggest ZNF224 as a prognostic and predictive molecular marker of CLL disease." @default.
• W4308558708 created "2022-11-12" @default.
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• W4308558708 date "2022-11-09" @default.
• W4308558708 modified "2023-10-16" @default.
• W4308558708 title "Biological relevance of ZNF224 expression in chronic lymphocytic leukemia and its implication IN NF-kB pathway regulation" @default.
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• W4308558708 cites W154103547 @default.
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• W4308558708 cites W1868478050 @default.
• W4308558708 cites W1871677735 @default.
• W4308558708 cites W1963942187 @default.
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• W4308558708 cites W1966327575 @default.
• W4308558708 cites W1971435237 @default.
• W4308558708 cites W1972235120 @default.
• W4308558708 cites W1975938433 @default.
• W4308558708 cites W1976130423 @default.
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• W4308558708 cites W2086637735 @default.
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• W4308558708 cites W2118986158 @default.
• W4308558708 cites W2121396722 @default.
• W4308558708 cites W2132344035 @default.
• W4308558708 cites W2136877606 @default.
• W4308558708 cites W2138320991 @default.
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• W4308558708 doi "https://doi.org/10.3389/fmolb.2022.1010984" @default.
• W4308558708 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36425656" @default.
• W4308558708 hasPublicationYear "2022" @default.
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