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• W4308558977 endingPage "104451" @default.
• W4308558977 startingPage "104451" @default.
• W4308558977 abstract "Preeclampsia (PE) is a hypertension-associated disease, and resveratrol (RES) is a polyphenol recognized to present beneficial effects in cardiovascular disease including hypertension. Recently, attentions have come to the therapeutic effect of RES in PE, but the underlying molecular mechanisms remain largely unknown. This study sought to delineate the mechanistic basis regarding bioinformatically identified miR-363-3p/PEDF/VEGF axis for RES treatment in PE. PE-like symptoms were induced in vivo in Sprague-Dawley rats by intraperitoneal injection with Ng-nitro-L-arginine methyl ester (L-NAME), and hypoxia was induced in vitro in trophoblasts by CoCl2. Accordingly, RES was found to enhance viability, migration, angiogenesis, and to repress the apoptosis of hypoxic trophoblasts in vitro. Furthermore, in vivo experiments noted that RES alleviated placental injury and promoted angiogenesis in rats with PE-like symptoms in vivo by increasing VEGF via promoting miR-363-3p-mediated PEDF suppression. Collectively, RES ameliorates PE by upregulating VEGF through miR-363-3p-mediated PEDF downregulation, the mechanism of which may be of promising significance to augment RES efficacy in PE treatment." @default.
• W4308558977 created "2022-11-12" @default.
• W4308558977 creator A5027835055 @default.
• W4308558977 creator A5064710679 @default.
• W4308558977 creator A5079594267 @default.
• W4308558977 date "2023-03-01" @default.
• W4308558977 modified "2023-10-18" @default.
• W4308558977 title "Resveratrol alleviates preeclampsia-like symptoms in rats through a mechanism involving the miR-363-3p/PEDF/VEGF axis" @default.
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• W4308558977 doi "https://doi.org/10.1016/j.mvr.2022.104451" @default.
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