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• W4308559099 endingPage "122081" @default.
• W4308559099 startingPage "122081" @default.
• W4308559099 abstract "A single pot microwave assisted method was employed to synthesize a series of novel pyrido fused imidazo[4,5-c]quinolines. The electronic properties of these derivatives were investigated by following their photophysical behaviour under isolated and solvated conditions via computational and experimental approaches. The solvatochromic effect of these derivatives was investigated in the ground and excited singlet states by following the absorption and fluorescence emission and excitation spectra. Further the effect of general and specific solvent effects were also investigated by plotting Stokes shift against Lippert-Mataga, ET(30) and Kamlet-Taft polarity parameters respectively. The deviation from linearity in ET(30) plot indicates that formation of different species in polar protic solvents. The biological applications of these derivatives as potential drug candidates were evaluated by in silico computational methods followed by pharmacokinetic properties predictions. The ability of these derivatives to inhibit human casein kinase 2 (CK2) was evaluated. The structure activity relationships were correlated by evaluating the electronic properties through experimental photophysical investigations including solvatochromic effect and computational electronic structure calculations. Of the various derivatives, p-nitro phenyl substituted pyrido fused imidazo[4,5-c]quinoline exhibited good inhibitory activity against CK2 enzyme and hence could serve as a promising drug candidate." @default.
• W4308559099 created "2022-11-12" @default.
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• W4308559099 date "2023-02-01" @default.
• W4308559099 modified "2023-09-26" @default.
• W4308559099 title "Photophysical evaluation on the electronic properties of synthesized biologically significant pyrido fused imidazo[4,5-c]quinolines" @default.
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• W4308559099 doi "https://doi.org/10.1016/j.saa.2022.122081" @default.
• W4308559099 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36379086" @default.
• W4308559099 hasPublicationYear "2023" @default.
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