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• W4308559743 abstract "Abstract Background Infections affecting neonates caused by Staphylococcus aureus are widespread in healthcare facilities; hence, novel strategies are needed to fight this pathogen. In this study, we aimed to investigate the effectiveness of the FDA-approved medications ascorbic acid, dexamethasone, and sodium bicarbonate to reduce the virulence of the resistant Staphylococcus aureus bacteria that causes neonatal sepsis and seek out suitable alternatives to the problem of multi-drug resistance. Methods Tested drugs were assessed phenotypically and genotypically for their effects on virulence factors and virulence-encoding genes in Staphylococcus aureus . Furthermore, drugs were tested in vivo for their ability to reduce Staphylococcus aureus pathogenesis. Results Sub-inhibitory concentrations (1/8 MIC) of ascorbic acid, dexamethasone, and sodium bicarbonate reduced the production of Staphylococcus aureus virulence factors, including biofilm formation, staphyloxanthin, proteases, and hemolysin production, as well as resistance to oxidative stress. At the molecular level, qRT-PCR was used to assess the relative expression levels of crtM , sigB , sarA , agrA , hla , fnbA , and icaA genes regulating virulence factors production and showed a significant reduction in the relative expression levels of all the tested genes. Conclusions The current findings reveal that ascorbic acid, dexamethasone, and sodium bicarbonate have strong anti-virulence effects against Staphylococcus aureus . Thus, suggesting that they might be used as adjuvants to treat infections caused by Staphylococcus aureus in combination with conventional antimicrobials or as alternative therapies." @default.
• W4308559743 created "2022-11-12" @default.
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• W4308559743 date "2022-11-09" @default.
• W4308559743 modified "2023-09-25" @default.
• W4308559743 title "Attenuating the virulence of the resistant superbug Staphylococcus aureus bacteria isolated from neonatal sepsis by ascorbic acid, dexamethasone, and sodium bicarbonate" @default.
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• W4308559743 cites W1967320859 @default.
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• W4308559743 doi "https://doi.org/10.1186/s12866-022-02684-x" @default.
• W4308559743 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36348266" @default.
• W4308559743 hasPublicationYear "2022" @default.
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