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• W4308564922 abstract "Abstract MLL -rearranged leukemias are among the leukemic subtypes with poorest survival, and treatment options have barely improved over the last decades. Furthermore, despite increasing molecular understanding of the mechanisms behind these hematopoietic malignancies, this knowledge has had poor translation into the clinic. Identification of novel treatment methods is hampered by the lack of relevant in vivo models that allow for rapid identification of actionable drug targets and small molecule inhibitors. Here, we report a Drosophila melanogaster model system to explore the pathways affected in MLL -rearranged leukemia. We show that expression of the human leukemic oncogene MLL-AF4 in the Drosophila hematopoietic system resulted in increased levels of circulating hemocytes and an enlargement of the larval hematopoietic organ, the lymph gland. Strikingly, depletion of Drosophila orthologs of known interactors of MLL-AF4, such as DOT1L, rescued the leukemic phenotype. In agreement, treatment with small-molecule inhibitors of DOT1L also prevented the MLL-AF4-induced leukemia-like phenotype. Taken together, this model provides an in vivo system to unravel the genetic interactors involved in leukemogenesis and offers a strategy for a prompt identification of potential therapeutic options for treatment of MLL -rearranged leukemia." @default.
• W4308564922 created "2022-11-12" @default.
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• W4308564922 date "2022-11-08" @default.
• W4308564922 modified "2023-10-15" @default.
• W4308564922 title "The human leukemic oncogene MLL-AF4 promotes hyperplastic growth of hematopoietic tissues in<i>Drosophila</i>larvae" @default.
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• W4308564922 cites W1984980675 @default.
• W4308564922 cites W1985171686 @default.
• W4308564922 cites W1987401543 @default.
• W4308564922 cites W1990739246 @default.
• W4308564922 cites W2013814945 @default.
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• W4308564922 cites W2026288613 @default.
• W4308564922 cites W2035478311 @default.
• W4308564922 cites W2047653899 @default.
• W4308564922 cites W2059171174 @default.
• W4308564922 cites W2059813239 @default.
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• W4308564922 doi "https://doi.org/10.1101/2022.11.08.515565" @default.
• W4308564922 hasPublicationYear "2022" @default.
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