FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308568322> ?p ?o ?g. }

• W4308568322 endingPage "331" @default.
• W4308568322 startingPage "322" @default.
• W4308568322 abstract "The accurate identification of mucinous pancreatic cystic lesions (PCLs) is paramount for cancer risk stratification. Cyst fluid carcinoembryonic antigen (CEA), the only routinely used test, requires high volumes and has low sensitivity. We aimed to compare the performance of two investigational small-volume biomarkers, glucose and the protease gastricsin, to CEA for PCL classification.We obtained cyst fluid samples from 81 patients with pathologically confirmed PCLs from four institutions between 2003 and 2016. Gastricsin activity was measured using an internally quenched fluorescent substrate. Glucose levels were measured with a standard glucometer. CEA levels were obtained from the medical record. Models using Classification and Regression Trees were created to predict mucinous status. Model performance was evaluated using nested cross-validation.Gastricsin activity, CEA, and glucose levels from patients with mucinous (n = 50) and nonmucinous (n = 31) PCLs were analyzed. Area under the curve (AUC) was similar for individual classifiers (gastricsin volume normalized [GVN] 0.88; gastricsin protein concentration normalized [GPN] 0.95; glucose 0.83; CEA 0.84). The combination of two classifiers did not significantly improve AUC, with CEA + GVN (0.88) performing similarly to CEA + GPN (0.95), GVN + glucose (0.87), GPN + glucose (0.95), and CEA + glucose (0.84). The three-analyte combination performed similarly to single and dual classifiers (GPN + glucose + CEA AUC 0.95; GVN + glucose + CEA AUC 0.87). After multiple comparison corrections, there were no significant differences between the individual, dual, and triple classifiers.Gastricsin and glucose performed similarly to CEA and required <5% of the volume required for CEA; these classifiers may be useful in patients with limited cyst fluid. Future multicenter prospective studies are needed to validate and compare these novel small-volume biomarkers." @default.
• W4308568322 created "2022-11-12" @default.
• W4308568322 creator A5001245424 @default.
• W4308568322 creator A5014807498 @default.
• W4308568322 creator A5015843387 @default.
• W4308568322 creator A5031603638 @default.
• W4308568322 creator A5032997225 @default.
• W4308568322 creator A5039387801 @default.
• W4308568322 creator A5043861958 @default.
• W4308568322 creator A5051059014 @default.
• W4308568322 creator A5051264184 @default.
• W4308568322 creator A5061454499 @default.
• W4308568322 creator A5078706922 @default.
• W4308568322 creator A5081780284 @default.
• W4308568322 creator A5085701533 @default.
• W4308568322 creator A5087001996 @default.
• W4308568322 date "2023-04-01" @default.
• W4308568322 modified "2023-10-16" @default.
• W4308568322 title "Accurate Identification of Mucinous Pancreatic Cystic Lesions Using Small-Volume Analytes" @default.
• W4308568322 cites W1602387341 @default.
• W4308568322 cites W1969088014 @default.
• W4308568322 cites W1973909869 @default.
• W4308568322 cites W1976785521 @default.
• W4308568322 cites W1989466606 @default.
• W4308568322 cites W1998011852 @default.
• W4308568322 cites W2037328359 @default.
• W4308568322 cites W2063562637 @default.
• W4308568322 cites W2068516781 @default.
• W4308568322 cites W2073400663 @default.
• W4308568322 cites W2114997989 @default.
• W4308568322 cites W2129804864 @default.
• W4308568322 cites W2129986414 @default.
• W4308568322 cites W2316544231 @default.
• W4308568322 cites W2507733246 @default.
• W4308568322 cites W2537595611 @default.
• W4308568322 cites W2606455082 @default.
• W4308568322 cites W2736069212 @default.
• W4308568322 cites W2759917145 @default.
• W4308568322 cites W2772723966 @default.
• W4308568322 cites W2798191310 @default.
• W4308568322 cites W2801701284 @default.
• W4308568322 cites W2888895287 @default.
• W4308568322 cites W2916806170 @default.
• W4308568322 cites W2962649098 @default.
• W4308568322 cites W2965626254 @default.
• W4308568322 cites W2988027843 @default.
• W4308568322 doi "https://doi.org/10.1016/j.jss.2022.08.014" @default.
• W4308568322 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36369049" @default.
• W4308568322 hasPublicationYear "2023" @default.
• W4308568322 type Work @default.
• W4308568322 citedByCount "0" @default.
• W4308568322 crossrefType "journal-article" @default.
• W4308568322 hasAuthorship W4308568322A5001245424 @default.
• W4308568322 hasAuthorship W4308568322A5014807498 @default.
• W4308568322 hasAuthorship W4308568322A5015843387 @default.
• W4308568322 hasAuthorship W4308568322A5031603638 @default.
• W4308568322 hasAuthorship W4308568322A5032997225 @default.
• W4308568322 hasAuthorship W4308568322A5039387801 @default.
• W4308568322 hasAuthorship W4308568322A5043861958 @default.
• W4308568322 hasAuthorship W4308568322A5051059014 @default.
• W4308568322 hasAuthorship W4308568322A5051264184 @default.
• W4308568322 hasAuthorship W4308568322A5061454499 @default.
• W4308568322 hasAuthorship W4308568322A5078706922 @default.
• W4308568322 hasAuthorship W4308568322A5081780284 @default.
• W4308568322 hasAuthorship W4308568322A5085701533 @default.
• W4308568322 hasAuthorship W4308568322A5087001996 @default.
• W4308568322 hasConcept C10390740 @default.
• W4308568322 hasConcept C121608353 @default.
• W4308568322 hasConcept C126322002 @default.
• W4308568322 hasConcept C142724271 @default.
• W4308568322 hasConcept C185592680 @default.
• W4308568322 hasConcept C2777387746 @default.
• W4308568322 hasConcept C2778764654 @default.
• W4308568322 hasConcept C2780210213 @default.
• W4308568322 hasConcept C2780597408 @default.
• W4308568322 hasConcept C2989005 @default.
• W4308568322 hasConcept C43617362 @default.
• W4308568322 hasConcept C71924100 @default.
• W4308568322 hasConcept C76318530 @default.
• W4308568322 hasConcept C90924648 @default.
• W4308568322 hasConceptScore W4308568322C10390740 @default.
• W4308568322 hasConceptScore W4308568322C121608353 @default.
• W4308568322 hasConceptScore W4308568322C126322002 @default.
• W4308568322 hasConceptScore W4308568322C142724271 @default.
• W4308568322 hasConceptScore W4308568322C185592680 @default.
• W4308568322 hasConceptScore W4308568322C2777387746 @default.
• W4308568322 hasConceptScore W4308568322C2778764654 @default.
• W4308568322 hasConceptScore W4308568322C2780210213 @default.
• W4308568322 hasConceptScore W4308568322C2780597408 @default.
• W4308568322 hasConceptScore W4308568322C2989005 @default.
• W4308568322 hasConceptScore W4308568322C43617362 @default.
• W4308568322 hasConceptScore W4308568322C71924100 @default.
• W4308568322 hasConceptScore W4308568322C76318530 @default.
• W4308568322 hasConceptScore W4308568322C90924648 @default.
• W4308568322 hasLocation W43085683221 @default.
• W4308568322 hasLocation W43085683222 @default.
• W4308568322 hasOpenAccess W4308568322 @default.
• W4308568322 hasPrimaryLocation W43085683221 @default.

• next