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- W4308578630 abstract "Statins have been widely used to prevent cardiovascular disease in middle-aged and elderly populations; however, the effect of long-term treatment on cognitive function is controversial. To simulate clinical conditions, middle-aged rats were given atorvastatin for 9 consecutive months to investigate the effect on natural cognitive decline and the possible mechanisms.The results showed that compared with the control group, long-term atorvastatin treatment naturally improved cognitive decline. Furthermore, long-term treatment regulated intestinal retinoic acid (RA) metabolism and storage by altering retinol dehydrogenase 7 (Rdh7) expression in the intestine, while RA metabolism affected the proliferation of intestinal Treg cells and inhibited IL-17+γδ T-cell function. In addition, long-term atorvastatin increased intestinal flora richness and decreased IL-17 expression in hippocampal tissue.Collectively, these findings provide the first evidence that long-term atorvastatin intervention may prevent cognitive decline in naturally ageing rats by inhibiting neuroinflammation via the gut-brain axis." @default.
- W4308578630 created "2022-11-12" @default.
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- W4308578630 date "2022-11-09" @default.
- W4308578630 modified "2023-10-09" @default.
- W4308578630 title "Long-term atorvastatin improves cognitive decline by regulating gut function in naturally ageing rats" @default.
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- W4308578630 doi "https://doi.org/10.1186/s12979-022-00311-x" @default.
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