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- W4308578889 abstract "Women diagnosed with triple negative breast cancer can benefit neither from endocrine therapy nor from HER2-targeted therapies (1). We mined published microarray datasets (2, 3) to determine in an unbiased fashion and at the systems level genes most differentially expressed in the primary tumors of patients with triple negative breast cancer. We report here significant differential expression of the gene encoding histone cluster 1, H2ae, HIST1H2AE, when comparing the tumor cells of patients with triple negative breast cancer to normal mammary ductal cells (2). HIST1H2AE was also differentially expressed in the brain metastases of patients with metastatic breast cancer (3). HIST1H2AE mRNA was present at significantly increased quantities in TNBC tumor cells relative to normal mammary ductal cells. Analysis of human survival data revealed that expression of HIST1H2AE in primary tumors of the breast was correlated with overall survival in all patients with luminal B breast cancer, while within triple negative breast cancer, primary tumor expression of HIST1H2AE was correlated with overall survival in patients with basal-like 1 subtype disease. HIST1H2AE may be of relevance to initiation, maintenance or progression of triple negative breast cancers." @default.
- W4308578889 created "2022-11-12" @default.
- W4308578889 creator A5024900493 @default.
- W4308578889 date "2022-11-09" @default.
- W4308578889 modified "2023-10-16" @default.
- W4308578889 title "Differential expression of histone cluster 1, H2ae in triple negative breast cancer." @default.
- W4308578889 doi "https://doi.org/10.31219/osf.io/qvxh5" @default.
- W4308578889 hasPublicationYear "2022" @default.
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