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- W4308579047 abstract "COVID-19 epidemic had a significant impact on many aspects of people lives, when these people urged to quarantine and lockdown to prevent the virus from spreading which had a major effect on people’s mental health, depression and stress. Many internal and environmental causes contribute to this stress, which has a detrimental impact on the body’s homeostasis. As a result, stress may have an impact on the body’s ability to conflict pathogens using its energy. Many recent studies have revealed strong associations between human mental stress and secretion of hormones, prohormones and/or immunological substances, part of these studies have confirmed the correlation between stress and the salivary CgA level, also Secretory IgA (sIgA) plays an important role in immunity by binding the surface molecules of pathogenic microorganisms and preventing adhesion and colonization. The aim of this study is to measure salivary chromogranin A as a stress biomarker as well as Secretory IgA levels among COVID-19 patients. 84 samples were collected from adults who have been divided into two groups: COVID-19 group consists of 42 patients and COVID-19 free group which consists of 42 subjects. All subjects undergo PCR test to confirm their healthy status, collection of unstimulated saliva was done and laboratory investigations was carried out to measure the salivary chromogranin A and Salivary IgA levels by the use of chromogranin A kit (human CGA ELISA kit) by alshakirate establishment for medical supply and SIgA kit (IgA saliva ELISA) by LDN company. SPSS version 21 was used for statistical analysis. Salivary chromogranin A was substantially greater in the COVID-19 group than in the COVID-19 free group, whereas secretory IgA was lower in the COVID-19 group, according to the statistical analysis. In conclusion a significant negative association was found between salivary chromogranin A and secretory IgA (p = 0.001).so, when the concentration of salivary chromogranin A elevated in the COVID-19 group, the level of secretory IgA reduced." @default.
- W4308579047 created "2022-11-12" @default.
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- W4308579047 date "2022-10-15" @default.
- W4308579047 modified "2023-09-27" @default.
- W4308579047 title "Salivary chromogranin as a stress biomarker and secretory IgA among COVID-19 patients" @default.
- W4308579047 doi "https://doi.org/10.51470/bca.2022.22.2.3767" @default.
- W4308579047 hasPublicationYear "2022" @default.
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