FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308579531> ?p ?o ?g. }

• W4308579531 endingPage "100251" @default.
• W4308579531 startingPage "100251" @default.
• W4308579531 abstract "Exposure to chemicals generally occurs in the form of mixtures. However, the great majority of the toxicity data, upon which chemical safety decisions are based, relate only to single compounds. It is currently unfeasible to test a fully representative proportion of mixtures for potential harmful effects and, as such, in silico modelling provides a practical solution to inform safety assessment. Traditional methodologies for deriving estimations of mixture effects, exemplified by principles such as concentration addition (CA) and independent action (IA), are limited as regards the scope of chemical combinations to which they can reliably be applied. Development of appropriate quantitative structure-activity relationships (QSARs) has been put forward as a solution to the shortcomings present within these techniques – allowing for the potential formulation of versatile predictive tools capable of capturing the activities of a full contingent of possible mixtures. This review addresses the current state-of-the-art as regards application of QSAR towards mixture toxicity, discussing the challenges inherent in the task, whilst considering the strengths and limitations of existing approaches. Forty studies are examined within – through reference to several characteristic elements including the nature of the chemicals and endpoints modelled, the form of descriptors adopted, and the principles behind the statistical techniques employed. Recommendations are in turn provided for practices which may assist in further advancing the field, most notably with regards to ensuring confidence in the acquired predictions." @default.
• W4308579531 created "2022-11-12" @default.
• W4308579531 creator A5005277925 @default.
• W4308579531 creator A5008818649 @default.
• W4308579531 creator A5017267691 @default.
• W4308579531 creator A5035541912 @default.
• W4308579531 creator A5076945768 @default.
• W4308579531 creator A5084970371 @default.
• W4308579531 date "2023-02-01" @default.
• W4308579531 modified "2023-10-01" @default.
• W4308579531 title "A review of quantitative structure-activity relationship modelling approaches to predict the toxicity of mixtures" @default.
• W4308579531 cites W1876373251 @default.
• W4308579531 cites W1964388922 @default.
• W4308579531 cites W1964778553 @default.
• W4308579531 cites W1965265038 @default.
• W4308579531 cites W1970428016 @default.
• W4308579531 cites W1973048127 @default.
• W4308579531 cites W1974194978 @default.
• W4308579531 cites W1978508989 @default.
• W4308579531 cites W1978520750 @default.
• W4308579531 cites W1983537912 @default.
• W4308579531 cites W1984915272 @default.
• W4308579531 cites W1990651822 @default.
• W4308579531 cites W2006683077 @default.
• W4308579531 cites W2009784360 @default.
• W4308579531 cites W2012486655 @default.
• W4308579531 cites W2017741794 @default.
• W4308579531 cites W2020182610 @default.
• W4308579531 cites W2025533533 @default.
• W4308579531 cites W2027288594 @default.
• W4308579531 cites W2027355356 @default.
• W4308579531 cites W2033757486 @default.
• W4308579531 cites W2034084562 @default.
• W4308579531 cites W2039787512 @default.
• W4308579531 cites W2040459007 @default.
• W4308579531 cites W2043254643 @default.
• W4308579531 cites W2046470917 @default.
• W4308579531 cites W2051084041 @default.
• W4308579531 cites W2053345793 @default.
• W4308579531 cites W2054754190 @default.
• W4308579531 cites W2055138006 @default.
• W4308579531 cites W2059058833 @default.
• W4308579531 cites W2060737851 @default.
• W4308579531 cites W2065765564 @default.
• W4308579531 cites W2073696737 @default.
• W4308579531 cites W2074330926 @default.
• W4308579531 cites W2079228578 @default.
• W4308579531 cites W2083439025 @default.
• W4308579531 cites W2084427432 @default.
• W4308579531 cites W2085885436 @default.
• W4308579531 cites W2094620339 @default.
• W4308579531 cites W2095392124 @default.
• W4308579531 cites W2111906798 @default.
• W4308579531 cites W2117857301 @default.
• W4308579531 cites W2141115907 @default.
• W4308579531 cites W2158656833 @default.
• W4308579531 cites W2219886491 @default.
• W4308579531 cites W2318579595 @default.
• W4308579531 cites W2320205132 @default.
• W4308579531 cites W2406870242 @default.
• W4308579531 cites W2413842318 @default.
• W4308579531 cites W2464700157 @default.
• W4308579531 cites W2488306898 @default.
• W4308579531 cites W2735384890 @default.
• W4308579531 cites W2740875536 @default.
• W4308579531 cites W2745936943 @default.
• W4308579531 cites W2765630448 @default.
• W4308579531 cites W2782057417 @default.
• W4308579531 cites W2792896688 @default.
• W4308579531 cites W2801991413 @default.
• W4308579531 cites W2884487870 @default.
• W4308579531 cites W2886516169 @default.
• W4308579531 cites W2889052904 @default.
• W4308579531 cites W2899423838 @default.
• W4308579531 cites W2922956166 @default.
• W4308579531 cites W2940061564 @default.
• W4308579531 cites W2942368446 @default.
• W4308579531 cites W2946129589 @default.
• W4308579531 cites W2984957779 @default.
• W4308579531 cites W2991126542 @default.
• W4308579531 cites W3043112581 @default.
• W4308579531 cites W3095955650 @default.
• W4308579531 cites W3161819977 @default.
• W4308579531 cites W4212910933 @default.
• W4308579531 doi "https://doi.org/10.1016/j.comtox.2022.100251" @default.
• W4308579531 hasPublicationYear "2023" @default.
• W4308579531 type Work @default.
• W4308579531 citedByCount "3" @default.
• W4308579531 countsByYear W43085795312023 @default.
• W4308579531 crossrefType "journal-article" @default.
• W4308579531 hasAuthorship W4308579531A5005277925 @default.
• W4308579531 hasAuthorship W4308579531A5008818649 @default.
• W4308579531 hasAuthorship W4308579531A5017267691 @default.
• W4308579531 hasAuthorship W4308579531A5035541912 @default.
• W4308579531 hasAuthorship W4308579531A5076945768 @default.
• W4308579531 hasAuthorship W4308579531A5084970371 @default.
• W4308579531 hasBestOaLocation W43085795311 @default.
• W4308579531 hasConcept C112930515 @default.

• next