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- W4308580168 startingPage "1659" @default.
- W4308580168 abstract "Macrophages regulate cutaneous wound healing by immune surveillance, tissue repair and remodelling. The depletion of dermal macrophages during the early and middle stages of wound healing has a detrimental impact on wound closure, characterised by reduced vessel density, fibroblast and myofibroblast proliferation, delayed re-epithelization and abated post-healing fibrosis and scar formation. However, in some animal species, oral mucosa and foetal life, cutaneous wounds can heal normally and remain scarless without any involvement of macrophages. These paradoxical observations have created much controversy on macrophages’ indispensable role in skin wound healing. Advanced knowledge gained by characterising macrophage subsets, their plasticity in switching phenotypes and molecular drivers provides new insights into their functional importance during cutaneous wound healing. In this review, we highlight the recent findings on skin macrophage subsets, their functional role in adult cutaneous wound healing and the potential benefits of targeting them for therapeutic use." @default.
- W4308580168 created "2022-11-12" @default.
- W4308580168 creator A5032792064 @default.
- W4308580168 creator A5035641630 @default.
- W4308580168 creator A5045972248 @default.
- W4308580168 creator A5089378663 @default.
- W4308580168 date "2022-11-08" @default.
- W4308580168 modified "2023-10-05" @default.
- W4308580168 title "Macrophages in Skin Wounds: Functions and Therapeutic Potential" @default.
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