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• W4308581282 endingPage "13682" @default.
• W4308581282 startingPage "13682" @default.
• W4308581282 abstract "Anticancer peptide (ACP) is a short peptide with less than 50 amino acids that has been discovered in a variety of foods. It has been demonstrated that traditional Chinese medicine or food can help treat cancer in some cases, which suggests that ACP may be one of the therapeutic ingredients. Studies on the anti-cancer properties of Sanghuangporus sanghuang have concentrated on polysaccharides, flavonoids, triterpenoids, etc. The function of peptides has not received much attention. The purpose of this study is to use computer mining techniques to search for potential anticancer peptides from 62 proteins of Sanghuang. We used mACPpred to perform sequence scans after theoretical trypsin hydrolysis and discovered nine fragments with an anticancer probability of over 0.60. The study used AlphaFold 2 to perform structural modeling of the first three ACPs discovered, which had blast results from the Cancer PPD database. Using reverse docking technology, we found the target proteins and interacting residues of two ACPs with an unknown mechanism. Reverse docking results predicted the binding modes of the ACPs and their target protein. In addition, we determined the active part of ACPs by quantum chemical calculation. Our study provides a framework for the future discovery of functional peptides from foods. The ACPs discovered have the potential to be used as drugs in oncology clinical treatment after further research." @default.
• W4308581282 created "2022-11-12" @default.
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• W4308581282 date "2022-11-08" @default.
• W4308581282 modified "2023-09-30" @default.
• W4308581282 title "In Silico Discovery of Anticancer Peptides from Sanghuang" @default.
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• W4308581282 doi "https://doi.org/10.3390/ijms232213682" @default.
• W4308581282 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36430160" @default.
• W4308581282 hasPublicationYear "2022" @default.
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