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- W4308583242 abstract "Fluorescence in situ hybridization (FISH) is the gold standard for visualizing genomic DNA in fixed cells and tissues, but it is incompatible with live-cell imaging, and its combination with RNA imaging is challenging. Consequently, due to its capacity to bind double-stranded DNA (dsDNA) and design flexibility, the clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (CRISPR-Cas9) technology has sparked enormous interest over the past decade. In this review, we describe various nucleic acid (NA)- and protein-based (amplified) signal generation methods that achieve imaging of repetitive and single-copy sequences, and even single-nucleotide variants (SNVs), next to highly multiplexed as well as dynamic imaging in live cells. With future progress in the field, the CRISPR-(d)Cas9-based technology promises to break through as a next-generation cell-imaging technique." @default.
- W4308583242 created "2022-11-12" @default.
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- W4308583242 date "2023-06-01" @default.
- W4308583242 modified "2023-10-03" @default.
- W4308583242 title "Imaging the unimaginable: leveraging signal generation of CRISPR-Cas for sensitive genome imaging" @default.
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- W4308583242 doi "https://doi.org/10.1016/j.tibtech.2022.10.003" @default.
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