FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308583755> ?p ?o ?g. }

• W4308583755 endingPage "254" @default.
• W4308583755 startingPage "239" @default.
• W4308583755 abstract "Identifying protein antigenic epitopes that are recognizable by antibodies is a key step in immunologic research. This type of research has broad medical applications, such as new immunodiagnostic reagent discovery, vaccine design, and antibody design. However, due to the countless possibilities of potential epitopes, the experimental search through trial and error would be too costly and time-consuming to be practical. To facilitate this process and improve its efficiency, computational methods were developed to predict both linear epitopes and discontinuous antigenic epitopes. For linear B-cell epitope prediction, many methods were developed, including PREDITOP, PEOPLE, BEPITOPE, BepiPred, COBEpro, ABCpred, AAP, BCPred, BayesB, BEOracle/BROracle, BEST, LBEEP, DRREP, iBCE-EL, SVMTriP, etc. For the more challenging yet important task of discontinuous epitope prediction, methods were also developed, including CEP, DiscoTope, PEPITO, ElliPro, SEPPA, EPITOPIA, PEASE, EpiPred, SEPIa, EPCES, EPSVR, etc. In this chapter, we will discuss computational methods for B-cell epitope predictions of both linear and discontinuous epitopes. SVMTriP and EPCES/EPCSVR, the most successful among the methods for each type of the predictions, will be used as model methods to detail the standard protocols. For linear epitope prediction, SVMTriP was reported to achieve a sensitivity of 80.1% and a precision of 55.2% with a fivefold cross-validation based on a large dataset, yielding an AUC of 0.702. For discontinuous or conformational B-cell epitope prediction, EPCES and EPCSVR were both benchmarked by a curated independent test dataset in which all antigens had no complex structures with the antibody. The identified epitopes by these methods were later independently validated by various biochemical experiments. For these three model methods, webservers and all datasets are publicly available at http://sysbio.unl.edu/SVMTriP , http://sysbio.unl.edu/EPCES/ , and http://sysbio.unl.edu/EPSVR/ ." @default.
• W4308583755 created "2022-11-12" @default.
• W4308583755 creator A5026629569 @default.
• W4308583755 creator A5051769353 @default.
• W4308583755 creator A5088141052 @default.
• W4308583755 date "2022-11-09" @default.
• W4308583755 modified "2023-10-14" @default.
• W4308583755 title "B-Cell Epitope Predictions Using Computational Methods" @default.
• W4308583755 cites W1526839960 @default.
• W4308583755 cites W1530470635 @default.
• W4308583755 cites W1535117461 @default.
• W4308583755 cites W1537551666 @default.
• W4308583755 cites W1795576732 @default.
• W4308583755 cites W1968361401 @default.
• W4308583755 cites W1980121140 @default.
• W4308583755 cites W1981194976 @default.
• W4308583755 cites W1983113740 @default.
• W4308583755 cites W1993568862 @default.
• W4308583755 cites W1997851414 @default.
• W4308583755 cites W2014744153 @default.
• W4308583755 cites W2028339001 @default.
• W4308583755 cites W2033664155 @default.
• W4308583755 cites W2035014358 @default.
• W4308583755 cites W2035652746 @default.
• W4308583755 cites W2039611529 @default.
• W4308583755 cites W2040074453 @default.
• W4308583755 cites W2042492527 @default.
• W4308583755 cites W2053418558 @default.
• W4308583755 cites W2059178238 @default.
• W4308583755 cites W2059538836 @default.
• W4308583755 cites W2066609648 @default.
• W4308583755 cites W2069163783 @default.
• W4308583755 cites W2073908337 @default.
• W4308583755 cites W2087202599 @default.
• W4308583755 cites W2087230890 @default.
• W4308583755 cites W2087937056 @default.
• W4308583755 cites W2095104107 @default.
• W4308583755 cites W2097850195 @default.
• W4308583755 cites W2097874743 @default.
• W4308583755 cites W2099821106 @default.
• W4308583755 cites W2102046002 @default.
• W4308583755 cites W2104760790 @default.
• W4308583755 cites W2108760877 @default.
• W4308583755 cites W2110298304 @default.
• W4308583755 cites W2125866257 @default.
• W4308583755 cites W2126101541 @default.
• W4308583755 cites W2130887658 @default.
• W4308583755 cites W2140468230 @default.
• W4308583755 cites W2143881057 @default.
• W4308583755 cites W2147863530 @default.
• W4308583755 cites W2149458203 @default.
• W4308583755 cites W2149984099 @default.
• W4308583755 cites W2158714788 @default.
• W4308583755 cites W2158781610 @default.
• W4308583755 cites W2158899863 @default.
• W4308583755 cites W2160397907 @default.
• W4308583755 cites W2163174206 @default.
• W4308583755 cites W2171732889 @default.
• W4308583755 cites W2195861155 @default.
• W4308583755 cites W2212129211 @default.
• W4308583755 cites W2287932004 @default.
• W4308583755 cites W2424537621 @default.
• W4308583755 cites W2544105246 @default.
• W4308583755 cites W2562638954 @default.
• W4308583755 cites W2587515533 @default.
• W4308583755 cites W2594940330 @default.
• W4308583755 cites W2748378282 @default.
• W4308583755 cites W2762181149 @default.
• W4308583755 cites W2789811841 @default.
• W4308583755 cites W2791393509 @default.
• W4308583755 cites W2799857202 @default.
• W4308583755 cites W2884557428 @default.
• W4308583755 cites W2887337852 @default.
• W4308583755 cites W2969923816 @default.
• W4308583755 cites W3016253312 @default.
• W4308583755 cites W3169242228 @default.
• W4308583755 doi "https://doi.org/10.1007/978-1-0716-2609-2_12" @default.
• W4308583755 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36346595" @default.
• W4308583755 hasPublicationYear "2022" @default.
• W4308583755 type Work @default.
• W4308583755 citedByCount "0" @default.
• W4308583755 crossrefType "book-chapter" @default.
• W4308583755 hasAuthorship W4308583755A5026629569 @default.
• W4308583755 hasAuthorship W4308583755A5051769353 @default.
• W4308583755 hasAuthorship W4308583755A5088141052 @default.
• W4308583755 hasConcept C147483822 @default.
• W4308583755 hasConcept C159654299 @default.
• W4308583755 hasConcept C195616568 @default.
• W4308583755 hasConcept C203014093 @default.
• W4308583755 hasConcept C41008148 @default.
• W4308583755 hasConcept C70721500 @default.
• W4308583755 hasConcept C86803240 @default.
• W4308583755 hasConceptScore W4308583755C147483822 @default.
• W4308583755 hasConceptScore W4308583755C159654299 @default.
• W4308583755 hasConceptScore W4308583755C195616568 @default.
• W4308583755 hasConceptScore W4308583755C203014093 @default.
• W4308583755 hasConceptScore W4308583755C41008148 @default.
• W4308583755 hasConceptScore W4308583755C70721500 @default.

• next