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- W4308583995 abstract "Structure-based site-directed affinity maturation of antibodies can be expanded by multiple-point mutations to obtain various mutants. However, selecting the appropriate number of promising mutants for experimental evaluation from the vast number of combinations of multiple-point mutations is challenging. In this report, we describe how to narrow candidate mutants using the so-called weak interaction analysis such as CH–π and CH–O in addition to widely recognized interactions such as hydrogen bonds." @default.
- W4308583995 created "2022-11-12" @default.
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- W4308583995 date "2022-11-09" @default.
- W4308583995 modified "2023-09-27" @default.
- W4308583995 title "Structure-Based Affinity Maturation of Antibody Based on Double-Point Mutations" @default.
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- W4308583995 doi "https://doi.org/10.1007/978-1-0716-2609-2_18" @default.
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