FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308587997> ?p ?o ?g. }

• W4308587997 abstract "Multiple studies show increased severity of SARS-CoV2-infection in patients with comorbidities such as hypertension and diabetes. In this study, we have prepared two herbal-based formulations, a pleiotropic herbal drink (Jin Si Herbal Tea, JHT) and a nasal drop (Jin Si nasal drop, JND), to provide preventive care against SARS-CoV2 infection. The effect of JHT and JND was determined in SARS-CoV2-S-pseudotyped lentivirus-infected bronchial and colorectal cell lines and in SKH-1 mouse models. For preliminary studies, ACE2 receptor abundant bronchial (Calu-3) and colorectal cells (Caco-2) were used to determine the effect of JHT and JND on the host entry of various variants of SARS-CoV2-S-pseudotyped lentivirus. A series of experiments were performed to understand the infection rate in SKH-1 mice (6 weeks old, n = 9), find the effective dosage of JHT and JND, and determine the combination effect of JHT and JND on the entry and adhesion of various variant SARS-CoV2-S-pseudotyped lentiviruses, which included highly transmissible delta and gamma mutants. Furthermore, the effect of combined JHT and JND was determined on diabetes-induced SKH-1 mice against the comorbidity-associated intense viral entry and accumulation. In addition, the effect of combined JHT and JND administration on viral transmission from infected SKH-1 mice to uninfected cage mate mice was determined. The results showed that both JHT and JND were effective in alleviating the viral entry and accumulation in the thorax and the abdominal area. While JHT showed a dose-dependent decrease in the viral load, JND showed early inhibition of viral entry from day 1 of the infection. Combined administration of 48.66 mg of JHT and 20 µL of JND showed rapid reduction in the viral entry and reduced the viral load (97-99%) in the infected mice within 3 days of treatment. Moreover, 16.22 mg of JHT and 20 µL JND reduced the viral infection in STZ-induced diabetic SKH-1 mice. Interestingly, combined JHT and JND also inhibited viral transmission among cage mates. The results, therefore, showed that combined administration of JHT and JND is a novel and an efficient strategy to potentially prevent SARS-CoV2 infection." @default.
• W4308587997 created "2022-11-12" @default.
• W4308587997 creator A5006212022 @default.
• W4308587997 creator A5017165971 @default.
• W4308587997 creator A5021916657 @default.
• W4308587997 creator A5025617602 @default.
• W4308587997 creator A5028798273 @default.
• W4308587997 creator A5069586997 @default.
• W4308587997 creator A5075133537 @default.
• W4308587997 creator A5079367503 @default.
• W4308587997 creator A5087584598 @default.
• W4308587997 creator A5088227603 @default.
• W4308587997 date "2022-11-08" @default.
• W4308587997 modified "2023-10-12" @default.
• W4308587997 title "Combined effect of traditional Chinese herbal-based formulations Jing Si herbal tea and Jing Si nasal drop inhibits adhesion and transmission of SARS-CoV2 in diabetic SKH-1 mice" @default.
• W4308587997 cites W1870945317 @default.
• W4308587997 cites W2006286994 @default.
• W4308587997 cites W2041378377 @default.
• W4308587997 cites W2062891727 @default.
• W4308587997 cites W2064076043 @default.
• W4308587997 cites W2101506295 @default.
• W4308587997 cites W3004348779 @default.
• W4308587997 cites W3008193851 @default.
• W4308587997 cites W3009358174 @default.
• W4308587997 cites W3009912996 @default.
• W4308587997 cites W3014067025 @default.
• W4308587997 cites W3015989800 @default.
• W4308587997 cites W3018002427 @default.
• W4308587997 cites W3038063455 @default.
• W4308587997 cites W3045108086 @default.
• W4308587997 cites W3045198070 @default.
• W4308587997 cites W3047903500 @default.
• W4308587997 cites W3082501133 @default.
• W4308587997 cites W3088861255 @default.
• W4308587997 cites W3089727605 @default.
• W4308587997 cites W3093768302 @default.
• W4308587997 cites W3095266798 @default.
• W4308587997 cites W3096064145 @default.
• W4308587997 cites W3109897200 @default.
• W4308587997 cites W3114035267 @default.
• W4308587997 cites W3115978472 @default.
• W4308587997 cites W3125753453 @default.
• W4308587997 cites W3130576827 @default.
• W4308587997 cites W3153955588 @default.
• W4308587997 cites W3154838434 @default.
• W4308587997 cites W3158941934 @default.
• W4308587997 cites W3160004557 @default.
• W4308587997 cites W3163533747 @default.
• W4308587997 cites W3164160541 @default.
• W4308587997 cites W3164721049 @default.
• W4308587997 cites W3164811968 @default.
• W4308587997 cites W3180285023 @default.
• W4308587997 cites W4205399324 @default.
• W4308587997 cites W4212939400 @default.
• W4308587997 cites W4223485325 @default.
• W4308587997 cites W4281632796 @default.
• W4308587997 doi "https://doi.org/10.3389/fphar.2022.953438" @default.
• W4308587997 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36425575" @default.
• W4308587997 hasPublicationYear "2022" @default.
• W4308587997 type Work @default.
• W4308587997 citedByCount "2" @default.
• W4308587997 countsByYear W43085879972023 @default.
• W4308587997 crossrefType "journal-article" @default.
• W4308587997 hasAuthorship W4308587997A5006212022 @default.
• W4308587997 hasAuthorship W4308587997A5017165971 @default.
• W4308587997 hasAuthorship W4308587997A5021916657 @default.
• W4308587997 hasAuthorship W4308587997A5025617602 @default.
• W4308587997 hasAuthorship W4308587997A5028798273 @default.
• W4308587997 hasAuthorship W4308587997A5069586997 @default.
• W4308587997 hasAuthorship W4308587997A5075133537 @default.
• W4308587997 hasAuthorship W4308587997A5079367503 @default.
• W4308587997 hasAuthorship W4308587997A5087584598 @default.
• W4308587997 hasAuthorship W4308587997A5088227603 @default.
• W4308587997 hasBestOaLocation W43085879971 @default.
• W4308587997 hasConcept C126322002 @default.
• W4308587997 hasConcept C134018914 @default.
• W4308587997 hasConcept C555293320 @default.
• W4308587997 hasConcept C71924100 @default.
• W4308587997 hasConcept C98274493 @default.
• W4308587997 hasConceptScore W4308587997C126322002 @default.
• W4308587997 hasConceptScore W4308587997C134018914 @default.
• W4308587997 hasConceptScore W4308587997C555293320 @default.
• W4308587997 hasConceptScore W4308587997C71924100 @default.
• W4308587997 hasConceptScore W4308587997C98274493 @default.
• W4308587997 hasFunder F4320336177 @default.
• W4308587997 hasLocation W43085879971 @default.
• W4308587997 hasLocation W43085879972 @default.
• W4308587997 hasLocation W43085879973 @default.
• W4308587997 hasOpenAccess W4308587997 @default.
• W4308587997 hasPrimaryLocation W43085879971 @default.
• W4308587997 hasRelatedWork W1563850031 @default.
• W4308587997 hasRelatedWork W1995515455 @default.
• W4308587997 hasRelatedWork W2045367862 @default.
• W4308587997 hasRelatedWork W2074686124 @default.
• W4308587997 hasRelatedWork W2415759662 @default.
• W4308587997 hasRelatedWork W2748952813 @default.
• W4308587997 hasRelatedWork W2899084033 @default.
• W4308587997 hasRelatedWork W3031052312 @default.
• W4308587997 hasRelatedWork W3032375762 @default.
• W4308587997 hasRelatedWork W3036934084 @default.

• next