Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308589327> ?p ?o ?g. }
Showing items 1 to 60 of
60
with 100 items per page.
- W4308589327 abstract "Research for novel vaccine adjuvants remains a critical need to improve the immune responses to a recombinant vaccine antigen. Emulsion adjuvants such as AS03 and MF59, particularly in the area of Influenza vaccines, have shown antigen dose sparing and allowed reduced immunizations. It was previously demonstrated that these emulsion adjuvants can be formulated using a simpler, low shear process of self-emulsification. The role of alpha tocopherol as an immunomodulator in emulsion adjuvants is evident from the success of AS03 in the on-going covid-19 pandemic. Although, it was a challenge to formulate alpha tocopherol with a low shear process to get closer to the AS03 composition, the self-emulsified version referred as self-emulsifying adjuvant systems (SE-AS) showed comparable immune responses to AS03 when co-administered with a Quadrivalent influenza virus (QIV) vaccine. In this paper, we first optimized the SE-AS with alpha tocopherol referred to as SE-AS44 to allow sterile filtration. We compared the in vitro cytokine profile with self-emulsifying adjuvant 160 (SEA160), a squalene-only self-emulsified adjuvant with composition similar to MF59. We compared SE-AS44 and SEA160 co-administered with a recombinant cytomegalovirus (CMV) pentamer antigen, which is a less immunogenic antigen, in vivo to compare the antibody and T-cell responses, in different adjuvanted groups, in C57BL/6 mice." @default.
- W4308589327 created "2022-11-12" @default.
- W4308589327 creator A5014602548 @default.
- W4308589327 creator A5035943717 @default.
- W4308589327 creator A5044262252 @default.
- W4308589327 creator A5055331519 @default.
- W4308589327 creator A5064469636 @default.
- W4308589327 creator A5074619583 @default.
- W4308589327 date "2022-11-07" @default.
- W4308589327 modified "2023-10-03" @default.
- W4308589327 title "A Self-Emulsified Adjuvant System Containing Alpha-Tocopherol Induced Higher Neutralizing Antibody Responses than a Squalene Only Emulsion Against a Recombinant Cytomegalovirus (CMV) Pentamer Antigen" @default.
- W4308589327 doi "https://doi.org/10.20944/preprints202211.0123.v1" @default.
- W4308589327 hasPublicationYear "2022" @default.
- W4308589327 type Work @default.
- W4308589327 citedByCount "0" @default.
- W4308589327 crossrefType "posted-content" @default.
- W4308589327 hasAuthorship W4308589327A5014602548 @default.
- W4308589327 hasAuthorship W4308589327A5035943717 @default.
- W4308589327 hasAuthorship W4308589327A5044262252 @default.
- W4308589327 hasAuthorship W4308589327A5055331519 @default.
- W4308589327 hasAuthorship W4308589327A5064469636 @default.
- W4308589327 hasAuthorship W4308589327A5074619583 @default.
- W4308589327 hasBestOaLocation W43085893271 @default.
- W4308589327 hasConcept C147483822 @default.
- W4308589327 hasConcept C159047783 @default.
- W4308589327 hasConcept C159654299 @default.
- W4308589327 hasConcept C185592680 @default.
- W4308589327 hasConcept C203014093 @default.
- W4308589327 hasConcept C2776703722 @default.
- W4308589327 hasConcept C2777863537 @default.
- W4308589327 hasConcept C55493867 @default.
- W4308589327 hasConcept C71924100 @default.
- W4308589327 hasConcept C8891405 @default.
- W4308589327 hasConceptScore W4308589327C147483822 @default.
- W4308589327 hasConceptScore W4308589327C159047783 @default.
- W4308589327 hasConceptScore W4308589327C159654299 @default.
- W4308589327 hasConceptScore W4308589327C185592680 @default.
- W4308589327 hasConceptScore W4308589327C203014093 @default.
- W4308589327 hasConceptScore W4308589327C2776703722 @default.
- W4308589327 hasConceptScore W4308589327C2777863537 @default.
- W4308589327 hasConceptScore W4308589327C55493867 @default.
- W4308589327 hasConceptScore W4308589327C71924100 @default.
- W4308589327 hasConceptScore W4308589327C8891405 @default.
- W4308589327 hasLocation W43085893271 @default.
- W4308589327 hasLocation W43085893272 @default.
- W4308589327 hasOpenAccess W4308589327 @default.
- W4308589327 hasPrimaryLocation W43085893271 @default.
- W4308589327 hasRelatedWork W1539989077 @default.
- W4308589327 hasRelatedWork W1674135449 @default.
- W4308589327 hasRelatedWork W1993025569 @default.
- W4308589327 hasRelatedWork W2087047282 @default.
- W4308589327 hasRelatedWork W2093242067 @default.
- W4308589327 hasRelatedWork W2095304551 @default.
- W4308589327 hasRelatedWork W2220102944 @default.
- W4308589327 hasRelatedWork W2478440915 @default.
- W4308589327 hasRelatedWork W3109192410 @default.
- W4308589327 hasRelatedWork W276659083 @default.
- W4308589327 isParatext "false" @default.
- W4308589327 isRetracted "false" @default.
- W4308589327 workType "article" @default.