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- W4308590523 abstract "Abstract Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease, involving neuroinflammation and T cell infiltration in the central nervous system. However, the contribution of T cell responses to the pathology of the disease is not fully understood. Here we show, by flow cytometric analysis of blood and cerebrospinal fluid (CSF) samples of a cohort of 89 newly diagnosed ALS patients in Stockholm, Sweden, that T cell phenotypes at the time of diagnosis are good predictors of disease outcome. High frequency of CD4 + FOXP3 − effector T cells in blood and CSF is associated with poor survival, whereas high frequency of activated regulatory T (Treg) cells and high ratio between activated and resting Treg cells in blood are associated with better survival. Besides survival, phenotypic profiling of T cells could also predict disease progression rate. Single cell transcriptomics analysis of CSF samples shows clonally expanded CD4 + and CD8 + T cells in CSF, with characteristic gene expression patterns. In summary, T cell responses associate with and likely contribute to disease progression in ALS, supporting modulation of adaptive immunity as a viable therapeutic option." @default.
- W4308590523 created "2022-11-12" @default.
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- W4308590523 date "2022-11-08" @default.
- W4308590523 modified "2023-10-11" @default.
- W4308590523 title "T cell responses at diagnosis of amyotrophic lateral sclerosis predict disease progression" @default.
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- W4308590523 doi "https://doi.org/10.1038/s41467-022-34526-9" @default.
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