Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308592641> ?p ?o ?g. }
- W4308592641 abstract "The study of microglia isolated from adult human brain tissue provides unique insight into the physiology of these brain immune cells and their role in adult human brain disorders. Reports of microglia in post-mortem adult human brain tissue show regional differences in microglial populations, however, these differences have not been fully explored in living microglia. In this study biopsy tissue was obtained from epileptic patients undergoing surgery and consisted of both cortical areas and neurogenic ventricular and hippocampal (Hp) areas. Microglia were concurrently isolated from both regions and compared by immunochemistry. Our initial observation was that a greater number of microglia resulted from isolation and culture of ventricular/Hp tissue than cortical tissue. This was found to be due to a greater proliferative capacity of microglia from ventricular/Hp regions compared to the cortex. Additionally, ventricular/Hp microglia had a greater proliferative response to the microglial mitogen Macrophage Colony-Stimulating Factor (M-CSF). This enhanced response was found to be associated with higher M-CSF receptor expression and higher expression of proteins involved in M-CSF signalling DAP12 and C/EBPβ. Microglia from the ventricular/Hp region also displayed higher expression of the receptor for Insulin-like Growth Factor-1, a molecule with some functional similarity to M-CSF. Compared to microglia isolated from the cortex, ventricular/Hp microglia showed increased HLA-DP, DQ, DR antigen presentation protein expression and a rounded morphology. These findings show that microglia from adult human brain neurogenic regions are more proliferative than cortical microglia and have a distinct protein expression profile. The data present a case for differential microglial phenotype and function in different regions of the adult human brain and suggest that microglia in adult neurogenic regions are “primed” to an activated state by their unique tissue environment." @default.
- W4308592641 created "2022-11-12" @default.
- W4308592641 creator A5002589388 @default.
- W4308592641 creator A5010513858 @default.
- W4308592641 creator A5039406430 @default.
- W4308592641 creator A5059449814 @default.
- W4308592641 creator A5064422913 @default.
- W4308592641 creator A5066157446 @default.
- W4308592641 creator A5088282584 @default.
- W4308592641 creator A5089572743 @default.
- W4308592641 date "2022-11-08" @default.
- W4308592641 modified "2023-09-27" @default.
- W4308592641 title "Distinct characteristics of microglia from neurogenic and non-neurogenic regions of the human brain in patients with Mesial Temporal Lobe Epilepsy" @default.
- W4308592641 cites W1541718087 @default.
- W4308592641 cites W1595413626 @default.
- W4308592641 cites W175813982 @default.
- W4308592641 cites W1924514319 @default.
- W4308592641 cites W1964041350 @default.
- W4308592641 cites W1966900192 @default.
- W4308592641 cites W1972310581 @default.
- W4308592641 cites W1973529716 @default.
- W4308592641 cites W1973838846 @default.
- W4308592641 cites W1984844169 @default.
- W4308592641 cites W1985301079 @default.
- W4308592641 cites W1985616298 @default.
- W4308592641 cites W1987270591 @default.
- W4308592641 cites W1990052445 @default.
- W4308592641 cites W1991165501 @default.
- W4308592641 cites W1996024251 @default.
- W4308592641 cites W1998694769 @default.
- W4308592641 cites W2003357296 @default.
- W4308592641 cites W2003982930 @default.
- W4308592641 cites W2015908426 @default.
- W4308592641 cites W2018878213 @default.
- W4308592641 cites W2020462665 @default.
- W4308592641 cites W2025501653 @default.
- W4308592641 cites W2031939272 @default.
- W4308592641 cites W2034387476 @default.
- W4308592641 cites W2044151676 @default.
- W4308592641 cites W2051205314 @default.
- W4308592641 cites W2051259034 @default.
- W4308592641 cites W2055091163 @default.
- W4308592641 cites W2057286959 @default.
- W4308592641 cites W2057750840 @default.
- W4308592641 cites W2067856703 @default.
- W4308592641 cites W2070968699 @default.
- W4308592641 cites W2073268901 @default.
- W4308592641 cites W2083056059 @default.
- W4308592641 cites W2084504347 @default.
- W4308592641 cites W2085663788 @default.
- W4308592641 cites W2094470133 @default.
- W4308592641 cites W2094660330 @default.
- W4308592641 cites W2101108887 @default.
- W4308592641 cites W2104473972 @default.
- W4308592641 cites W2109120242 @default.
- W4308592641 cites W2111792540 @default.
- W4308592641 cites W2122968144 @default.
- W4308592641 cites W2123505941 @default.
- W4308592641 cites W2130445760 @default.
- W4308592641 cites W2140139281 @default.
- W4308592641 cites W2142096644 @default.
- W4308592641 cites W2146546664 @default.
- W4308592641 cites W2148898943 @default.
- W4308592641 cites W2151551770 @default.
- W4308592641 cites W2154622689 @default.
- W4308592641 cites W2155984519 @default.
- W4308592641 cites W2158704188 @default.
- W4308592641 cites W2159372753 @default.
- W4308592641 cites W2160779535 @default.
- W4308592641 cites W2163399650 @default.
- W4308592641 cites W2165787335 @default.
- W4308592641 cites W2170706621 @default.
- W4308592641 cites W2171549018 @default.
- W4308592641 cites W2397793632 @default.
- W4308592641 cites W2410922951 @default.
- W4308592641 cites W2905335418 @default.
- W4308592641 cites W3113163577 @default.
- W4308592641 cites W4205837091 @default.
- W4308592641 doi "https://doi.org/10.3389/fncel.2022.1047928" @default.
- W4308592641 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36425665" @default.
- W4308592641 hasPublicationYear "2022" @default.
- W4308592641 type Work @default.
- W4308592641 citedByCount "0" @default.
- W4308592641 crossrefType "journal-article" @default.
- W4308592641 hasAuthorship W4308592641A5002589388 @default.
- W4308592641 hasAuthorship W4308592641A5010513858 @default.
- W4308592641 hasAuthorship W4308592641A5039406430 @default.
- W4308592641 hasAuthorship W4308592641A5059449814 @default.
- W4308592641 hasAuthorship W4308592641A5064422913 @default.
- W4308592641 hasAuthorship W4308592641A5066157446 @default.
- W4308592641 hasAuthorship W4308592641A5088282584 @default.
- W4308592641 hasAuthorship W4308592641A5089572743 @default.
- W4308592641 hasBestOaLocation W43085926411 @default.
- W4308592641 hasConcept C126322002 @default.
- W4308592641 hasConcept C142724271 @default.
- W4308592641 hasConcept C148762608 @default.
- W4308592641 hasConcept C169760540 @default.
- W4308592641 hasConcept C170493617 @default.
- W4308592641 hasConcept C203014093 @default.
- W4308592641 hasConcept C2776914184 @default.