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• W4308593025 abstract "Background This study aims to investigate the relationship between preoperative body mass index changes (ΔBMI) and prognosis in patients with esophageal squamous cell carcinoma who underwent esophagectomy. Methods We identified 1,883 patients with esophageal squamous cell carcinoma who underwent curative resection in our department between January 2005 and December 2013. Patients were grouped into a stable body mass index (ΔBMI = 0) group and a decreased body mass index (ΔBMI &lt; 0) group. Risk factors for ΔBMI were assessed using logistic regression analysis. The impact of ΔBMI on survival was investigated using Kaplan–Meier curves and Cox regression. A nomogram for survival prediction was constructed and validated. Results The results showed that T stage (OR: 1.30, 95% CI: 1.16–1.45, P &lt; 0.001) and N stage (OR: 1.24, 95% CI: 1.11–1.38, P &lt; 0.001) were independent risk factors for ΔBMI. The ΔBMI &lt; 0 group had worse overall survival than the stable body mass index group (HR: 1.25, 95% CI: 1.08–1.44, P = 0.002). When stratified by stage, ΔBMI had the greatest prognostic impact in stage I tumors (HR: 1.82, 95%: 1.05–3.15, P = 0.033). In addition, multiple comparisons showed that decreasing ΔBMI correlated with worse prognosis. The ΔBMI-based nomogram presented good predictive ability with a C-index of 0.705. Conclusion This study demonstrates that ΔBMI &lt; 0 had an adverse impact on the long-term survival of patients with esophageal squamous cell carcinoma undergoing esophagectomy. These results may support further investigation of preoperative nutrition support." @default.
• W4308593025 created "2022-11-12" @default.
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• W4308593025 date "2022-11-08" @default.
• W4308593025 modified "2023-09-30" @default.
• W4308593025 title "The prognostic impact of preoperative body mass index changes for patients with esophageal squamous cell carcinoma who underwent esophagectomy: A large-scale long-term follow-up cohort study" @default.
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• W4308593025 doi "https://doi.org/10.3389/fnut.2022.947008" @default.
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