Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308593410> ?p ?o ?g. }
- W4308593410 abstract "Interstitial cystitis/bladder pain syndrome is a chronic inflammatory pelvic pain syndrome of unknown etiology characterized by a number of lower urinary tract symptoms, including increased urinary urgency and frequency, bladder discomfort, decreased bladder capacity, and pelvic pain. While its etiology remains unknown, a large body of evidence suggests a role for changes in neurotrophin signaling, particularly that of nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF). Here, we evaluated the effects of pharmacological inhibition of the NGF receptor TrkA, BDNF receptor TrkB, and pan-neurotrophin receptor p75 NTR on bladder function in acute (4-hour) and chronic (8-day) mouse models of cyclophosphamide (CYP)-induced cystitis. TrkA inhibition via ARRY-954 significantly increased intermicturition interval and bladder capacity in control and acute and chronic CYP-treatment conditions. TrkB inhibition via ANA-12 significantly increased intermicturition interval and bladder capacity in acute, but not chronic, CYP-treatment conditions. Interestingly, intermicturition interval and bladder capacity significantly increased following p75 NTR inhibition via LM11A-31 in the acute CYP-treatment condition, but decreased in the chronic condition, potentially due to compensatory changes in neurotrophin signaling or increased urothelial barrier dysfunction in the chronic condition. Our findings demonstrate that these receptors represent additional potent therapeutic targets in mice with cystitis and may be useful in the treatment of interstitial cystitis and other inflammatory disorders of the bladder." @default.
- W4308593410 created "2022-11-12" @default.
- W4308593410 creator A5027507990 @default.
- W4308593410 creator A5028592608 @default.
- W4308593410 creator A5049819763 @default.
- W4308593410 creator A5064602661 @default.
- W4308593410 creator A5078123103 @default.
- W4308593410 date "2022-11-08" @default.
- W4308593410 modified "2023-09-30" @default.
- W4308593410 title "Effects of pharmacological neurotrophin receptor inhibition on bladder function in female mice with cyclophosphamide-induced cystitis" @default.
- W4308593410 cites W1548879124 @default.
- W4308593410 cites W1581188730 @default.
- W4308593410 cites W1595479007 @default.
- W4308593410 cites W1596784725 @default.
- W4308593410 cites W1762338891 @default.
- W4308593410 cites W1824215458 @default.
- W4308593410 cites W1914763441 @default.
- W4308593410 cites W1977760840 @default.
- W4308593410 cites W1979915327 @default.
- W4308593410 cites W1980113161 @default.
- W4308593410 cites W1981108049 @default.
- W4308593410 cites W1984218330 @default.
- W4308593410 cites W1984634498 @default.
- W4308593410 cites W1986841583 @default.
- W4308593410 cites W1989713749 @default.
- W4308593410 cites W1996101006 @default.
- W4308593410 cites W1998173045 @default.
- W4308593410 cites W2001699192 @default.
- W4308593410 cites W2006295537 @default.
- W4308593410 cites W2009814772 @default.
- W4308593410 cites W2013488690 @default.
- W4308593410 cites W2014748042 @default.
- W4308593410 cites W2017255697 @default.
- W4308593410 cites W2017537032 @default.
- W4308593410 cites W2024876386 @default.
- W4308593410 cites W2026634713 @default.
- W4308593410 cites W2035303961 @default.
- W4308593410 cites W2036445582 @default.
- W4308593410 cites W2038381968 @default.
- W4308593410 cites W2042125279 @default.
- W4308593410 cites W2049844981 @default.
- W4308593410 cites W2052359962 @default.
- W4308593410 cites W2054602836 @default.
- W4308593410 cites W2055159392 @default.
- W4308593410 cites W2055755492 @default.
- W4308593410 cites W2056794468 @default.
- W4308593410 cites W2057198000 @default.
- W4308593410 cites W2063518214 @default.
- W4308593410 cites W2066544825 @default.
- W4308593410 cites W2067245070 @default.
- W4308593410 cites W2068146214 @default.
- W4308593410 cites W2084420320 @default.
- W4308593410 cites W2084447782 @default.
- W4308593410 cites W2085268292 @default.
- W4308593410 cites W2085295467 @default.
- W4308593410 cites W2089232660 @default.
- W4308593410 cites W2098117013 @default.
- W4308593410 cites W2108328978 @default.
- W4308593410 cites W2109358424 @default.
- W4308593410 cites W2111514922 @default.
- W4308593410 cites W2113423163 @default.
- W4308593410 cites W2131545168 @default.
- W4308593410 cites W2137445147 @default.
- W4308593410 cites W2137979524 @default.
- W4308593410 cites W2143589064 @default.
- W4308593410 cites W2145096738 @default.
- W4308593410 cites W2147467121 @default.
- W4308593410 cites W2149321742 @default.
- W4308593410 cites W2157002123 @default.
- W4308593410 cites W2157766864 @default.
- W4308593410 cites W2475453781 @default.
- W4308593410 cites W2546808469 @default.
- W4308593410 cites W2609354761 @default.
- W4308593410 cites W2766065694 @default.
- W4308593410 cites W2787723196 @default.
- W4308593410 cites W2790767158 @default.
- W4308593410 cites W2977187857 @default.
- W4308593410 cites W3004772127 @default.
- W4308593410 cites W3014604613 @default.
- W4308593410 cites W3082053594 @default.
- W4308593410 cites W91154270 @default.
- W4308593410 cites W1922664478 @default.
- W4308593410 doi "https://doi.org/10.3389/fruro.2022.1037511" @default.
- W4308593410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37701182" @default.
- W4308593410 hasPublicationYear "2022" @default.
- W4308593410 type Work @default.
- W4308593410 citedByCount "1" @default.
- W4308593410 countsByYear W43085934102023 @default.
- W4308593410 crossrefType "journal-article" @default.
- W4308593410 hasAuthorship W4308593410A5027507990 @default.
- W4308593410 hasAuthorship W4308593410A5028592608 @default.
- W4308593410 hasAuthorship W4308593410A5049819763 @default.
- W4308593410 hasAuthorship W4308593410A5064602661 @default.
- W4308593410 hasAuthorship W4308593410A5078123103 @default.
- W4308593410 hasBestOaLocation W43085934101 @default.
- W4308593410 hasConcept C121608353 @default.
- W4308593410 hasConcept C126322002 @default.
- W4308593410 hasConcept C134018914 @default.
- W4308593410 hasConcept C141071460 @default.
- W4308593410 hasConcept C160539049 @default.