FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308595845> ?p ?o ?g. }

• W4308595845 abstract "It has been well recognized that the tumor microenvironment serves important roles in the progression and invasion of cancer. The desmoplastic reaction (DR) is a fibrous tissue reaction around tumor cells, and the prognostic significance of DR in colorectal cancer (CRC) has been established. Tumor deposits (TD) are also an important prognostic indicator of CRC. Notably, immature type DR has been linked to poor prognosis. In addition, immature type DR is significantly associated with a higher pT stage, presence of lymphovascular invasion and lymph node metastasis; however, to the best of our knowledge, the association between DR and TD has not yet been examined. The present study aimed to clarify this association. This study included 443 consecutive patients with pT3 or pT4 CRC who underwent surgical resection. The histopathological features, including DR and TD, were evaluated. Statistical analyses of the presence of TD, DR and other clinicopathological parameters were performed. The present cohort included 205 female and 238 male patients; 293 (66.1%) and 150 (33.9%) patients were classified as pT3 and pT4, respectively. Immature, intermediate and mature DR were noted in 282 (63.7%), 91 (20.5%) and 70 patients (15.8%), respectively. TD was observed in 93 (21.0%) patients. Immature type DR was significantly associated with a higher pT stage (P<0.0001), presence of lymph node metastasis (P<0.0001), lymphatic (P=0.0007), venous (P<0.0001) and perineural invasion (P<0.0001), and higher tumor budding (TB) (P<0.0001). Moreover, immature type DR was significantly associated with the presence of TD (P<0.0001). The present study demonstrated a significant association between immature type DR and the presence of TD, and suggested a close relationship between lymphovascular invasion, DR, TB and TD. Additional studies are required to analyze the detailed mechanism underlying the development of immature DR in CRC to define novel treatment strategies." @default.
• W4308595845 created "2022-11-12" @default.
• W4308595845 creator A5022330536 @default.
• W4308595845 creator A5027019057 @default.
• W4308595845 creator A5028895443 @default.
• W4308595845 creator A5033065777 @default.
• W4308595845 creator A5043799958 @default.
• W4308595845 creator A5077899651 @default.
• W4308595845 creator A5077940502 @default.
• W4308595845 date "2022-11-08" @default.
• W4308595845 modified "2023-10-14" @default.
• W4308595845 title "Significance of desmoplastic reactions on tumor deposits in patients with colorectal cancer" @default.
• W4308595845 cites W1963872870 @default.
• W4308595845 cites W2020990511 @default.
• W4308595845 cites W2071823746 @default.
• W4308595845 cites W2097755600 @default.
• W4308595845 cites W2312333226 @default.
• W4308595845 cites W2565923131 @default.
• W4308595845 cites W2620163964 @default.
• W4308595845 cites W2750690344 @default.
• W4308595845 cites W2768210053 @default.
• W4308595845 cites W2946609186 @default.
• W4308595845 cites W2949128414 @default.
• W4308595845 cites W3083938091 @default.
• W4308595845 cites W3090087862 @default.
• W4308595845 cites W3095795983 @default.
• W4308595845 cites W3105948746 @default.
• W4308595845 cites W3110012019 @default.
• W4308595845 cites W3118937338 @default.
• W4308595845 cites W3156124497 @default.
• W4308595845 cites W4205598495 @default.
• W4308595845 cites W4220705822 @default.
• W4308595845 cites W4220931503 @default.
• W4308595845 cites W4223960191 @default.
• W4308595845 cites W4288758051 @default.
• W4308595845 doi "https://doi.org/10.3892/ol.2022.13587" @default.
• W4308595845 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36419753" @default.
• W4308595845 hasPublicationYear "2022" @default.
• W4308595845 type Work @default.
• W4308595845 citedByCount "1" @default.
• W4308595845 countsByYear W43085958452023 @default.
• W4308595845 crossrefType "journal-article" @default.
• W4308595845 hasAuthorship W4308595845A5022330536 @default.
• W4308595845 hasAuthorship W4308595845A5027019057 @default.
• W4308595845 hasAuthorship W4308595845A5028895443 @default.
• W4308595845 hasAuthorship W4308595845A5033065777 @default.
• W4308595845 hasAuthorship W4308595845A5043799958 @default.
• W4308595845 hasAuthorship W4308595845A5077899651 @default.
• W4308595845 hasAuthorship W4308595845A5077940502 @default.
• W4308595845 hasBestOaLocation W43085958451 @default.
• W4308595845 hasConcept C121608353 @default.
• W4308595845 hasConcept C126322002 @default.
• W4308595845 hasConcept C142724271 @default.
• W4308595845 hasConcept C143998085 @default.
• W4308595845 hasConcept C146357865 @default.
• W4308595845 hasConcept C151730666 @default.
• W4308595845 hasConcept C181152851 @default.
• W4308595845 hasConcept C2777154038 @default.
• W4308595845 hasConcept C2778740770 @default.
• W4308595845 hasConcept C2779013556 @default.
• W4308595845 hasConcept C2779188454 @default.
• W4308595845 hasConcept C2780849966 @default.
• W4308595845 hasConcept C29537977 @default.
• W4308595845 hasConcept C2992571226 @default.
• W4308595845 hasConcept C526805850 @default.
• W4308595845 hasConcept C67082663 @default.
• W4308595845 hasConcept C71924100 @default.
• W4308595845 hasConcept C86803240 @default.
• W4308595845 hasConcept C90924648 @default.
• W4308595845 hasConceptScore W4308595845C121608353 @default.
• W4308595845 hasConceptScore W4308595845C126322002 @default.
• W4308595845 hasConceptScore W4308595845C142724271 @default.
• W4308595845 hasConceptScore W4308595845C143998085 @default.
• W4308595845 hasConceptScore W4308595845C146357865 @default.
• W4308595845 hasConceptScore W4308595845C151730666 @default.
• W4308595845 hasConceptScore W4308595845C181152851 @default.
• W4308595845 hasConceptScore W4308595845C2777154038 @default.
• W4308595845 hasConceptScore W4308595845C2778740770 @default.
• W4308595845 hasConceptScore W4308595845C2779013556 @default.
• W4308595845 hasConceptScore W4308595845C2779188454 @default.
• W4308595845 hasConceptScore W4308595845C2780849966 @default.
• W4308595845 hasConceptScore W4308595845C29537977 @default.
• W4308595845 hasConceptScore W4308595845C2992571226 @default.
• W4308595845 hasConceptScore W4308595845C526805850 @default.
• W4308595845 hasConceptScore W4308595845C67082663 @default.
• W4308595845 hasConceptScore W4308595845C71924100 @default.
• W4308595845 hasConceptScore W4308595845C86803240 @default.
• W4308595845 hasConceptScore W4308595845C90924648 @default.
• W4308595845 hasIssue "1" @default.
• W4308595845 hasLocation W43085958451 @default.
• W4308595845 hasLocation W43085958452 @default.
• W4308595845 hasLocation W43085958453 @default.
• W4308595845 hasOpenAccess W4308595845 @default.
• W4308595845 hasPrimaryLocation W43085958451 @default.
• W4308595845 hasRelatedWork W2006316366 @default.
• W4308595845 hasRelatedWork W2149654447 @default.
• W4308595845 hasRelatedWork W2349769283 @default.
• W4308595845 hasRelatedWork W2356339361 @default.
• W4308595845 hasRelatedWork W2570707737 @default.
• W4308595845 hasRelatedWork W2907532902 @default.

• next