Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308599676> ?p ?o ?g. }
- W4308599676 endingPage "102649" @default.
- W4308599676 startingPage "102649" @default.
- W4308599676 abstract "Aging involves progressive deterioration away from homeostasis. Whereas the healthy adult brain maintains neuroimmune cells in a surveillant and homeostatic state, aged glial cells have a hyperreactive phenotype. These age-related pro-inflammatory biases are driven in part by cell-intrinsic factors, including increased cell priming and pro-inflammatory cell states. In addition, the aged inflammatory milieu is shaped by an altered environment, such as amplified danger signals and cytokines and dysregulated glymphatic function. These cell-instrinsic and environmental factors conspire to heighten the age-related risk for neuroimmune activation and associated pathology. In this review, we discuss cellular and molecular neuroimmune shifts with healthy aging; how these age-related changes affect physiology and behavior; and how recent research has revealed neuroimmune pathways and targets for improving health span." @default.
- W4308599676 created "2022-11-12" @default.
- W4308599676 creator A5051353828 @default.
- W4308599676 creator A5075773354 @default.
- W4308599676 date "2022-12-01" @default.
- W4308599676 modified "2023-10-09" @default.
- W4308599676 title "Neuroimmunology of healthy brain aging" @default.
- W4308599676 cites W1588685142 @default.
- W4308599676 cites W1771974095 @default.
- W4308599676 cites W1997132511 @default.
- W4308599676 cites W2029300652 @default.
- W4308599676 cites W2034275438 @default.
- W4308599676 cites W2100314515 @default.
- W4308599676 cites W2127716652 @default.
- W4308599676 cites W2150279416 @default.
- W4308599676 cites W2167183660 @default.
- W4308599676 cites W2469685265 @default.
- W4308599676 cites W2490024771 @default.
- W4308599676 cites W2580929144 @default.
- W4308599676 cites W2737955012 @default.
- W4308599676 cites W2782274120 @default.
- W4308599676 cites W2783874580 @default.
- W4308599676 cites W2788548733 @default.
- W4308599676 cites W2790139801 @default.
- W4308599676 cites W2883285706 @default.
- W4308599676 cites W2883628966 @default.
- W4308599676 cites W2884598197 @default.
- W4308599676 cites W2885498250 @default.
- W4308599676 cites W2888160268 @default.
- W4308599676 cites W2891781570 @default.
- W4308599676 cites W2894787694 @default.
- W4308599676 cites W2901838561 @default.
- W4308599676 cites W2902735396 @default.
- W4308599676 cites W2922321673 @default.
- W4308599676 cites W2943220296 @default.
- W4308599676 cites W2954434934 @default.
- W4308599676 cites W2958251376 @default.
- W4308599676 cites W2964087368 @default.
- W4308599676 cites W2973473061 @default.
- W4308599676 cites W2979366073 @default.
- W4308599676 cites W2979612914 @default.
- W4308599676 cites W3000061011 @default.
- W4308599676 cites W3009304300 @default.
- W4308599676 cites W3014752737 @default.
- W4308599676 cites W3015013495 @default.
- W4308599676 cites W3018541302 @default.
- W4308599676 cites W3022539327 @default.
- W4308599676 cites W3039975419 @default.
- W4308599676 cites W3041860193 @default.
- W4308599676 cites W3044101840 @default.
- W4308599676 cites W3080531673 @default.
- W4308599676 cites W3083317330 @default.
- W4308599676 cites W3083781882 @default.
- W4308599676 cites W3098744674 @default.
- W4308599676 cites W3113448250 @default.
- W4308599676 cites W3117031117 @default.
- W4308599676 cites W3125753820 @default.
- W4308599676 cites W3132186274 @default.
- W4308599676 cites W3134096424 @default.
- W4308599676 cites W3135705588 @default.
- W4308599676 cites W3137606405 @default.
- W4308599676 cites W3154836676 @default.
- W4308599676 cites W3163888514 @default.
- W4308599676 cites W3164896384 @default.
- W4308599676 cites W3171235218 @default.
- W4308599676 cites W3179549473 @default.
- W4308599676 cites W3189444842 @default.
- W4308599676 cites W3194004635 @default.
- W4308599676 cites W3196287359 @default.
- W4308599676 cites W3201931145 @default.
- W4308599676 cites W3206687244 @default.
- W4308599676 cites W3212236634 @default.
- W4308599676 cites W4200441876 @default.
- W4308599676 cites W4205753353 @default.
- W4308599676 cites W4206929509 @default.
- W4308599676 cites W4207034828 @default.
- W4308599676 cites W4210881650 @default.
- W4308599676 cites W4214574386 @default.
- W4308599676 cites W4214818594 @default.
- W4308599676 cites W4223592008 @default.
- W4308599676 cites W4226190883 @default.
- W4308599676 cites W4281553189 @default.
- W4308599676 cites W4282918296 @default.
- W4308599676 doi "https://doi.org/10.1016/j.conb.2022.102649" @default.
- W4308599676 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36368270" @default.
- W4308599676 hasPublicationYear "2022" @default.
- W4308599676 type Work @default.
- W4308599676 citedByCount "5" @default.
- W4308599676 countsByYear W43085996762023 @default.
- W4308599676 crossrefType "journal-article" @default.
- W4308599676 hasAuthorship W4308599676A5051353828 @default.
- W4308599676 hasAuthorship W4308599676A5075773354 @default.
- W4308599676 hasConcept C100701293 @default.
- W4308599676 hasConcept C101054994 @default.
- W4308599676 hasConcept C104317684 @default.
- W4308599676 hasConcept C127716648 @default.
- W4308599676 hasConcept C1491633281 @default.
- W4308599676 hasConcept C15744967 @default.