Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308607478> ?p ?o ?g. }
- W4308607478 abstract "Abstract Opium poppy accumulates copious amounts of several benzylisoquinoline alkaloids including morphine, noscapine, and papaverine, in the specialized cytoplasm of laticifers, which compose an internal secretory system associated with phloem throughout the plant. The contiguous latex includes an abundance of related proteins belonging to the pathogenesis-related (PR)10 family known collectively as major latex proteins (MLPs) and representing at least 35% of the total cellular protein content. Two latex MLP/PR10 proteins, thebaine synthase and neopione isomerase, have recently been shown to catalyze late steps in morphine biosynthesis previously assigned as spontaneous reactions. Using a combination of sucrose density-gradient fractionation-coupled proteomics, differential scanning fluorimetry, isothermal titration calorimetry, and X-ray crystallography, we show that the major latex proteins are a family of alkaloid-binding proteins that display altered conformation in the presence of certain ligands. Addition of MLP/PR10 proteins to yeast strains engineered with morphine biosynthetic genes from the plant significantly enhanced the conversion of salutaridine to morphinan alkaloids." @default.
- W4308607478 created "2022-11-13" @default.
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- W4308607478 date "2022-11-09" @default.
- W4308607478 modified "2023-10-14" @default.
- W4308607478 title "Alkaloid binding to opium poppy major latex proteins triggers structural modification and functional aggregation" @default.
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- W4308607478 cites W1964435550 @default.
- W4308607478 cites W1970082049 @default.
- W4308607478 cites W1972727051 @default.
- W4308607478 cites W1983043794 @default.
- W4308607478 cites W1997789131 @default.
- W4308607478 cites W1999006912 @default.
- W4308607478 cites W2006497539 @default.
- W4308607478 cites W2009307185 @default.
- W4308607478 cites W2011573718 @default.
- W4308607478 cites W2015575535 @default.
- W4308607478 cites W2016923036 @default.
- W4308607478 cites W2021212454 @default.
- W4308607478 cites W2025732180 @default.
- W4308607478 cites W2028846971 @default.
- W4308607478 cites W2030207192 @default.
- W4308607478 cites W2032876838 @default.
- W4308607478 cites W2038591876 @default.
- W4308607478 cites W2047178378 @default.
- W4308607478 cites W2049453454 @default.
- W4308607478 cites W2055647658 @default.
- W4308607478 cites W2074631079 @default.
- W4308607478 cites W2085375492 @default.
- W4308607478 cites W2086405466 @default.
- W4308607478 cites W2092688093 @default.
- W4308607478 cites W2093060333 @default.
- W4308607478 cites W2099236745 @default.
- W4308607478 cites W2114367386 @default.
- W4308607478 cites W2120521842 @default.
- W4308607478 cites W2122339645 @default.
- W4308607478 cites W2124026197 @default.
- W4308607478 cites W2128446478 @default.
- W4308607478 cites W2134962337 @default.
- W4308607478 cites W2134997023 @default.
- W4308607478 cites W2136788311 @default.
- W4308607478 cites W2147874841 @default.
- W4308607478 cites W2150436179 @default.
- W4308607478 cites W2166323054 @default.
- W4308607478 cites W2169932685 @default.
- W4308607478 cites W2180229411 @default.
- W4308607478 cites W2408112837 @default.
- W4308607478 cites W2487183634 @default.
- W4308607478 cites W2496322940 @default.
- W4308607478 cites W2510185479 @default.
- W4308607478 cites W2517653083 @default.
- W4308607478 cites W2590568317 @default.
- W4308607478 cites W2591309385 @default.
- W4308607478 cites W2598497808 @default.
- W4308607478 cites W2604349127 @default.
- W4308607478 cites W2605275874 @default.
- W4308607478 cites W2610541465 @default.
- W4308607478 cites W2743269523 @default.
- W4308607478 cites W2759119351 @default.
- W4308607478 cites W2762598691 @default.
- W4308607478 cites W2793921742 @default.
- W4308607478 cites W2797985037 @default.
- W4308607478 cites W2801456442 @default.
- W4308607478 cites W2804159523 @default.
- W4308607478 cites W2804182232 @default.
- W4308607478 cites W2804685008 @default.
- W4308607478 cites W2896758254 @default.
- W4308607478 cites W2900788271 @default.
- W4308607478 cites W2921720106 @default.
- W4308607478 cites W2939450856 @default.
- W4308607478 cites W2942861708 @default.
- W4308607478 cites W2970009644 @default.
- W4308607478 cites W3010107185 @default.
- W4308607478 cites W3036566101 @default.
- W4308607478 cites W3036616992 @default.
- W4308607478 cites W3042306696 @default.
- W4308607478 cites W3104225517 @default.
- W4308607478 cites W3107698834 @default.
- W4308607478 cites W3184772812 @default.
- W4308607478 cites W3187517745 @default.
- W4308607478 cites W3192038592 @default.
- W4308607478 cites W3201326693 @default.
- W4308607478 cites W4200381520 @default.
- W4308607478 cites W4221071494 @default.
- W4308607478 cites W4596269 @default.
- W4308607478 doi "https://doi.org/10.1038/s41467-022-34313-6" @default.
- W4308607478 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36351903" @default.
- W4308607478 hasPublicationYear "2022" @default.
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