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• W4308608911 abstract "Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline culminating in death. The complexity of intercellular interactions in the brain is challenging to unravel and the basis of disease pathobiology remains poorly understood. In this study, we employed single cell RNA sequencing (scRNAseq) to produce an atlas of 147,536 single cell transcriptomes from cortex and hippocampus of mice infected with prions and showing clinical signs. We identified transcriptionally distinct populations and sub-populations of all the major brain cell-types. Disease-related transcription was highly specific to not only overarching cell-types, but also to sub-populations of glia and neurons. Most striking was an apparent decrease in relative frequency of astrocytes expressing genes that are required for brain homeostasis such as lipid synthesis, glutamate clearance, synaptic modulation and regulation of blood flow. Additionally, we described a spectrum of microglial activation states that suggest delineation of phagocytic and neuroinflammatory functions in different cell subsets. Differential responses of immature and mature neuron populations were also observed, alongside abnormal hippocampal neurogenesis. Our scRNAseq library provides a new layer of knowledge on single cell gene expression in prion disease, and is a basis for a more detailed understanding of cellular interplay that leads to neurodegeneration." @default.
• W4308608911 created "2022-11-13" @default.
• W4308608911 creator A5003718692 @default.
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• W4308608911 creator A5082180865 @default.
• W4308608911 date "2022-11-09" @default.
• W4308608911 modified "2023-10-06" @default.
• W4308608911 title "Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease" @default.
• W4308608911 cites W11644991 @default.
• W4308608911 cites W131033830 @default.
• W4308608911 cites W1584602900 @default.
• W4308608911 cites W1858755391 @default.
• W4308608911 cites W1920140446 @default.
• W4308608911 cites W1969758868 @default.
• W4308608911 cites W1975683282 @default.
• W4308608911 cites W1975998453 @default.
• W4308608911 cites W1989816038 @default.
• W4308608911 cites W2010473698 @default.
• W4308608911 cites W2012601853 @default.
• W4308608911 cites W2021858341 @default.
• W4308608911 cites W2038139001 @default.
• W4308608911 cites W2042085543 @default.
• W4308608911 cites W2052935486 @default.
• W4308608911 cites W2064345924 @default.
• W4308608911 cites W2070050178 @default.
• W4308608911 cites W2076914359 @default.
• W4308608911 cites W2079083712 @default.
• W4308608911 cites W2091849737 @default.
• W4308608911 cites W2093987055 @default.
• W4308608911 cites W2099026515 @default.
• W4308608911 cites W2117186800 @default.
• W4308608911 cites W2125411036 @default.
• W4308608911 cites W2127242333 @default.
• W4308608911 cites W2127293863 @default.
• W4308608911 cites W2140616438 @default.
• W4308608911 cites W2154549928 @default.
• W4308608911 cites W2162002124 @default.
• W4308608911 cites W2163232636 @default.
• W4308608911 cites W2175136759 @default.
• W4308608911 cites W2210133089 @default.
• W4308608911 cites W2286142055 @default.
• W4308608911 cites W2307322413 @default.
• W4308608911 cites W2324660492 @default.
• W4308608911 cites W2341994568 @default.
• W4308608911 cites W2345356016 @default.
• W4308608911 cites W2406250479 @default.
• W4308608911 cites W2556496438 @default.
• W4308608911 cites W2557076287 @default.
• W4308608911 cites W2595789753 @default.
• W4308608911 cites W2645018614 @default.
• W4308608911 cites W2742369047 @default.
• W4308608911 cites W2906213364 @default.
• W4308608911 cites W2911556795 @default.
• W4308608911 cites W2911565945 @default.
• W4308608911 cites W2926010705 @default.
• W4308608911 cites W2942678593 @default.
• W4308608911 cites W2949177718 @default.
• W4308608911 cites W2953151710 @default.
• W4308608911 cites W2963860554 @default.
• W4308608911 cites W2971864028 @default.
• W4308608911 cites W2979590126 @default.
• W4308608911 cites W2998310368 @default.
• W4308608911 cites W3000299502 @default.
• W4308608911 cites W3003228785 @default.
• W4308608911 cites W3021619272 @default.
• W4308608911 cites W3037812738 @default.
• W4308608911 cites W3086150231 @default.
• W4308608911 cites W3087279494 @default.
• W4308608911 cites W3087821509 @default.
• W4308608911 cites W3091491962 @default.
• W4308608911 cites W3093508648 @default.
• W4308608911 cites W3094600150 @default.
• W4308608911 cites W3107595167 @default.
• W4308608911 cites W3109942090 @default.
• W4308608911 cites W3114078084 @default.
• W4308608911 cites W3126943997 @default.
• W4308608911 cites W3130437983 @default.
• W4308608911 cites W3132240972 @default.
• W4308608911 cites W3161437743 @default.
• W4308608911 cites W3161937579 @default.
• W4308608911 cites W3164440374 @default.
• W4308608911 cites W3164457652 @default.
• W4308608911 cites W3164692211 @default.
• W4308608911 cites W3180426587 @default.
• W4308608911 cites W3185694768 @default.
• W4308608911 cites W3200799038 @default.
• W4308608911 cites W3214271799 @default.
• W4308608911 cites W4200170135 @default.
• W4308608911 cites W4200354734 @default.
• W4308608911 cites W4214589631 @default.
• W4308608911 cites W4214892207 @default.
• W4308608911 cites W4220819957 @default.
• W4308608911 cites W4221040770 @default.
• W4308608911 cites W4221065117 @default.
• W4308608911 cites W4280558165 @default.
• W4308608911 cites W4290851113 @default.
• W4308608911 doi "https://doi.org/10.1186/s40478-022-01450-4" @default.
• W4308608911 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36352465" @default.

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