FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308616332> ?p ?o ?g. }

• W4308616332 endingPage "521" @default.
• W4308616332 startingPage "511" @default.
• W4308616332 abstract "Herpes simplex virus (HSV) infection is a leading cause of corneal blindness. However, keratoplasty is only rarely proposed due to the high frequency of graft failure and associated recurrences. Gene therapy of the corneal graft might provide sustained protection against HSV infection. To test that hypothesis, we designed a meganuclease specific to an HSV-1 DNA sequence coding for major capsid protein (UL19) and selected an adeno-associated virus type-2 as the vector. Meganuclease was transduced into corneas and its effect was challenged in vitro, ex vivo, and then in vivo in a rabbit HSV-1-infection model of stromal keratitis and endotheliitis. In vivo, meganuclease exposure resulted in fewer infected stromal and endothelial cells, and protected against corneal opacification and edema. Ex vivo, HSV-1 infection rates of meganuclease-treated human corneas were drastically reduced. Furthermore, genetically engineered corneas transplanted in vivo into rabbit eyes protected against HSV-1 infection. This genome-editing technology targeting HSV-1 opens new opportunities to manage severe post-herpetic corneal blindness by providing infected patients with genetically protected corneal transplants." @default.
• W4308616332 created "2022-11-13" @default.
• W4308616332 creator A5010586748 @default.
• W4308616332 creator A5020371132 @default.
• W4308616332 creator A5027087136 @default.
• W4308616332 creator A5033486587 @default.
• W4308616332 creator A5035292611 @default.
• W4308616332 creator A5037319640 @default.
• W4308616332 creator A5057620589 @default.
• W4308616332 date "2022-12-01" @default.
• W4308616332 modified "2023-10-17" @default.
• W4308616332 title "Meganuclease targeting HSV-1 protects against herpetic keratitis: Application to corneal transplants" @default.
• W4308616332 cites W105049771 @default.
• W4308616332 cites W1579432655 @default.
• W4308616332 cites W1608776257 @default.
• W4308616332 cites W1695142101 @default.
• W4308616332 cites W1972543205 @default.
• W4308616332 cites W2007735134 @default.
• W4308616332 cites W2045372639 @default.
• W4308616332 cites W2058304957 @default.
• W4308616332 cites W2061492996 @default.
• W4308616332 cites W2064119540 @default.
• W4308616332 cites W2065448076 @default.
• W4308616332 cites W2067487866 @default.
• W4308616332 cites W2072264084 @default.
• W4308616332 cites W2075228455 @default.
• W4308616332 cites W2090997908 @default.
• W4308616332 cites W2100475769 @default.
• W4308616332 cites W2107609182 @default.
• W4308616332 cites W2108832576 @default.
• W4308616332 cites W2119456020 @default.
• W4308616332 cites W2127944170 @default.
• W4308616332 cites W2139499737 @default.
• W4308616332 cites W2140523898 @default.
• W4308616332 cites W2156909017 @default.
• W4308616332 cites W2168939550 @default.
• W4308616332 cites W2330531548 @default.
• W4308616332 cites W2404545519 @default.
• W4308616332 cites W2512896334 @default.
• W4308616332 cites W2754256151 @default.
• W4308616332 cites W2897637939 @default.
• W4308616332 cites W2918533415 @default.
• W4308616332 cites W3119803887 @default.
• W4308616332 cites W4211052952 @default.
• W4308616332 cites W975637119 @default.
• W4308616332 doi "https://doi.org/10.1016/j.omtn.2022.11.006" @default.
• W4308616332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36457698" @default.
• W4308616332 hasPublicationYear "2022" @default.
• W4308616332 type Work @default.
• W4308616332 citedByCount "0" @default.
• W4308616332 crossrefType "journal-article" @default.
• W4308616332 hasAuthorship W4308616332A5010586748 @default.
• W4308616332 hasAuthorship W4308616332A5020371132 @default.
• W4308616332 hasAuthorship W4308616332A5027087136 @default.
• W4308616332 hasAuthorship W4308616332A5033486587 @default.
• W4308616332 hasAuthorship W4308616332A5035292611 @default.
• W4308616332 hasAuthorship W4308616332A5037319640 @default.
• W4308616332 hasAuthorship W4308616332A5057620589 @default.
• W4308616332 hasBestOaLocation W43086163321 @default.
• W4308616332 hasConcept C159047783 @default.
• W4308616332 hasConcept C169760540 @default.
• W4308616332 hasConcept C207001950 @default.
• W4308616332 hasConcept C2522874641 @default.
• W4308616332 hasConcept C26291073 @default.
• W4308616332 hasConcept C2776882836 @default.
• W4308616332 hasConcept C2778560704 @default.
• W4308616332 hasConcept C2781196997 @default.
• W4308616332 hasConcept C54355233 @default.
• W4308616332 hasConcept C86803240 @default.
• W4308616332 hasConceptScore W4308616332C159047783 @default.
• W4308616332 hasConceptScore W4308616332C169760540 @default.
• W4308616332 hasConceptScore W4308616332C207001950 @default.
• W4308616332 hasConceptScore W4308616332C2522874641 @default.
• W4308616332 hasConceptScore W4308616332C26291073 @default.
• W4308616332 hasConceptScore W4308616332C2776882836 @default.
• W4308616332 hasConceptScore W4308616332C2778560704 @default.
• W4308616332 hasConceptScore W4308616332C2781196997 @default.
• W4308616332 hasConceptScore W4308616332C54355233 @default.
• W4308616332 hasConceptScore W4308616332C86803240 @default.
• W4308616332 hasLocation W43086163321 @default.
• W4308616332 hasLocation W43086163322 @default.
• W4308616332 hasLocation W43086163323 @default.
• W4308616332 hasLocation W43086163324 @default.
• W4308616332 hasOpenAccess W4308616332 @default.
• W4308616332 hasPrimaryLocation W43086163321 @default.
• W4308616332 hasRelatedWork W1950501729 @default.
• W4308616332 hasRelatedWork W1993339219 @default.
• W4308616332 hasRelatedWork W2038801503 @default.
• W4308616332 hasRelatedWork W2055706740 @default.
• W4308616332 hasRelatedWork W2057824115 @default.
• W4308616332 hasRelatedWork W2066091494 @default.
• W4308616332 hasRelatedWork W2073329231 @default.
• W4308616332 hasRelatedWork W2162468440 @default.
• W4308616332 hasRelatedWork W2165613721 @default.
• W4308616332 hasRelatedWork W2412889041 @default.
• W4308616332 hasVolume "30" @default.
• W4308616332 isParatext "false" @default.
• W4308616332 isRetracted "false" @default.

• next