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• W4308637410 abstract "Some patients with therapy-related myeloid neoplasms (t-MN) may have unsuspected inherited cancer predisposition syndrome (CPS). We propose a set of clinical criteria to identify t-MN patients with high risk of CPS (HR-CPS). Among 225 t-MN patients with an antecedent non-myeloid malignancy, our clinical criteria identified 52 (23%) HR-CPS patients. Germline whole-exome sequencing identified pathogenic or likely pathogenic variants in 10 of 27 HR-CPS patients compared to 0 of 9 low-risk CPS patients (37% vs. 0%, p = 0.04). These simple clinical criteria identify t-MN patients most likely to benefit from genetic testing for inherited CPS." @default.
• W4308637410 created "2022-11-13" @default.
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• W4308637410 date "2022-11-09" @default.
• W4308637410 modified "2023-10-14" @default.
• W4308637410 title "Inherited cancer predisposing mutations in patients with therapy‐related myeloid neoplasms" @default.
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• W4308637410 doi "https://doi.org/10.1111/bjh.18543" @default.
• W4308637410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36349721" @default.
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