Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308643079> ?p ?o ?g. }
- W4308643079 endingPage "3414" @default.
- W4308643079 startingPage "3414" @default.
- W4308643079 abstract "Microglia, the main immune modulators of the central nervous system, have key roles in both the developing and adult brain. These functions include shaping healthy neuronal networks, carrying out immune surveillance, mediating inflammatory responses, and disposing of unwanted material. A wide variety of pathological conditions present with microglia dysregulation, highlighting the importance of these cells in both normal brain function and disease. Studies into microglial function in the context of both health and disease thus have the potential to provide tremendous insight across a broad range of research areas. In vitro culture of microglia, using primary cells, cell lines, or induced pluripotent stem cell derived microglia, allows researchers to generate reproducible, robust, and quantifiable data regarding microglia function. A broad range of assays have been successfully developed and optimised for characterizing microglial morphology, mediation of inflammation, endocytosis, phagocytosis, chemotaxis and random motility, and mediation of immunometabolism. This review describes the main functions of microglia, compares existing protocols for measuring these functions in vitro, and highlights common pitfalls and future areas for development. We aim to provide a comprehensive methodological guide for researchers planning to characterise microglial functions within a range of contexts and in vitro models." @default.
- W4308643079 created "2022-11-13" @default.
- W4308643079 creator A5024445452 @default.
- W4308643079 creator A5036747710 @default.
- W4308643079 creator A5048962601 @default.
- W4308643079 creator A5051291070 @default.
- W4308643079 creator A5056972463 @default.
- W4308643079 creator A5073066296 @default.
- W4308643079 date "2022-10-28" @default.
- W4308643079 modified "2023-09-25" @default.
- W4308643079 title "Assaying Microglia Functions In Vitro" @default.
- W4308643079 cites W1582111605 @default.
- W4308643079 cites W1591008663 @default.
- W4308643079 cites W1757580574 @default.
- W4308643079 cites W175813982 @default.
- W4308643079 cites W1770378670 @default.
- W4308643079 cites W1814713647 @default.
- W4308643079 cites W1817666133 @default.
- W4308643079 cites W1841826782 @default.
- W4308643079 cites W1853959720 @default.
- W4308643079 cites W1947551305 @default.
- W4308643079 cites W1971094792 @default.
- W4308643079 cites W1971181573 @default.
- W4308643079 cites W1974495821 @default.
- W4308643079 cites W1977213877 @default.
- W4308643079 cites W1980789245 @default.
- W4308643079 cites W1981919258 @default.
- W4308643079 cites W1992062692 @default.
- W4308643079 cites W1994030261 @default.
- W4308643079 cites W1996055705 @default.
- W4308643079 cites W2015068992 @default.
- W4308643079 cites W2015412022 @default.
- W4308643079 cites W2022811766 @default.
- W4308643079 cites W2025854398 @default.
- W4308643079 cites W2029190354 @default.
- W4308643079 cites W2029812916 @default.
- W4308643079 cites W2033617297 @default.
- W4308643079 cites W2042698977 @default.
- W4308643079 cites W2047964142 @default.
- W4308643079 cites W2052932605 @default.
- W4308643079 cites W2054275187 @default.
- W4308643079 cites W2055559193 @default.
- W4308643079 cites W2058478749 @default.
- W4308643079 cites W2060061788 @default.
- W4308643079 cites W2062916819 @default.
- W4308643079 cites W2064848717 @default.
- W4308643079 cites W2065048465 @default.
- W4308643079 cites W2067267561 @default.
- W4308643079 cites W2069245229 @default.
- W4308643079 cites W2071266986 @default.
- W4308643079 cites W2076019198 @default.
- W4308643079 cites W2086271423 @default.
- W4308643079 cites W2089663038 @default.
- W4308643079 cites W2090544000 @default.
- W4308643079 cites W2094660330 @default.
- W4308643079 cites W2097971052 @default.
- W4308643079 cites W2100326315 @default.
- W4308643079 cites W2100533805 @default.
- W4308643079 cites W2100592123 @default.
- W4308643079 cites W2103711259 @default.
- W4308643079 cites W2109315419 @default.
- W4308643079 cites W2112032807 @default.
- W4308643079 cites W2112048948 @default.
- W4308643079 cites W2115349822 @default.
- W4308643079 cites W2116715404 @default.
- W4308643079 cites W2118403357 @default.
- W4308643079 cites W2124257654 @default.
- W4308643079 cites W2124836944 @default.
- W4308643079 cites W2125236750 @default.
- W4308643079 cites W2129162586 @default.
- W4308643079 cites W2131686384 @default.
- W4308643079 cites W2140380746 @default.
- W4308643079 cites W2150740984 @default.
- W4308643079 cites W2153126018 @default.
- W4308643079 cites W2154156417 @default.
- W4308643079 cites W2156414024 @default.
- W4308643079 cites W2157757554 @default.
- W4308643079 cites W2158536428 @default.
- W4308643079 cites W2159367229 @default.
- W4308643079 cites W2160779535 @default.
- W4308643079 cites W2161327297 @default.
- W4308643079 cites W2170107264 @default.
- W4308643079 cites W2249750674 @default.
- W4308643079 cites W2291436232 @default.
- W4308643079 cites W2295670844 @default.
- W4308643079 cites W2431987552 @default.
- W4308643079 cites W2460612985 @default.
- W4308643079 cites W2465699308 @default.
- W4308643079 cites W2497241389 @default.
- W4308643079 cites W2513003953 @default.
- W4308643079 cites W2518285474 @default.
- W4308643079 cites W2522038806 @default.
- W4308643079 cites W2522122785 @default.
- W4308643079 cites W2523299174 @default.
- W4308643079 cites W2526809592 @default.
- W4308643079 cites W2527645962 @default.
- W4308643079 cites W2537351581 @default.
- W4308643079 cites W2560871830 @default.