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- W4308648839 abstract "Radical cystectomy is the standard treatment for muscle invasive bladder cancer. Using perioperative cisplatin-based chemotherapy, 5‑year overall survival rates are 5% higher with neoadjuvant chemotherapy compared to local therapy alone. New multimodal concepts have been developed to improve oncologic efficacy and to reduce treatment-related morbidity. Perioperative use of checkpoint inhibitors aims at improving efficacy, while bladder-preserving concepts try to avoid cystectomy in good responders. This article reviews new developments in radioimmunotherapy and perioperative combination therapies as well as bladder-preserving concepts like trimodal bladder therapy.Die radikale Blasentfernung ist die Standardtherapie beim muskelinvasiven Blasenkarzinom. Der Einsatz einer begleitenden, Cisplatin-haltigen Chemotherapie führt zu einer signifikanten Verbesserung des Gesamtüberlebens. Durch eine neoadjuvante Therapie steigt die 5‑Jahres-Gesamtüberlebensrate um 5 % im Vergleich zur alleinigen Lokaltherapie. Auf dieser Basis wurden verschiedene neuere, multimodale Therapiekonzepte entwickelt. Ein Teil dieser Konzepte strebt – wie bei der trimodalen Therapie – den Blasenerhalt an, um die mit der Zystektomie verbundene Morbidität zu verringern. Andere Konzepte – wie die neuen perioperativen Ansätze mit Checkpoint-Inhibitoren – werden entwickelt, um die onkologische Effektivität zu verbessern. Hier haben sich in der letzten Zeit interessante neue Entwicklungen ergeben, beispielsweise in der Radioimmuntherapie und in der perioperativen Kombinationstherapie. Diese sollen hier zusammen mit den Standardtherapien beleuchtet werden." @default.
- W4308648839 created "2022-11-13" @default.
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- W4308648839 date "2022-11-09" @default.
- W4308648839 modified "2023-10-06" @default.
- W4308648839 title "„Surgery only“ reicht nicht aus: Potenziale einer multimodalen Therapie beim Urothelkarzinom der Harnblase" @default.
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- W4308648839 doi "https://doi.org/10.1007/s00120-022-01963-9" @default.
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