FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308653764> ?p ?o ?g. }

• W4308653764 endingPage "15" @default.
• W4308653764 startingPage "1" @default.
• W4308653764 abstract "Baicalin (BA) is a major flavone from Scutellaria baicalensis Georgi and has showed significant curative effects in Parkinson’s and Alzheimer’s diseases. In the present study, we investigated the effects of BA on antineuroinflammation and related signaling cascade in lipopolysaccharide- (LPS-) induced BV-2 microglial model. The results showed that BA significantly attenuated inflammatory mediators (NO, iNOS, IL-1β, COX-2, and PGE2) and suppressed the expression of miR-155. More crucially, BA could regulate the expression of related proteins in Toll-like receptor 4 (TLR4)/myeloid differentiation protein 88 (MyD88)/nuclear factor κB (NF-κB) pathway and suppress the phosphorylation of mitogen-activated protein kinase (MAPK) family. In addition, molecular docking analysis indicated that BA binds to the amino acids Lie 63 and Tyr 65 of TLR4 by <math xmlns=http://www.w3.org/1998/Math/MathML id=M1> <mi>π</mi> </math> - <math xmlns=http://www.w3.org/1998/Math/MathML id=M2> <mi>σ</mi> </math> and <math xmlns=http://www.w3.org/1998/Math/MathML id=M3> <mi>π</mi> </math> - <math xmlns=http://www.w3.org/1998/Math/MathML id=M4> <mi>π</mi> </math> T-shaped interaction. Thus, BA suppressed the LPS-stimulated neuroinflammation in BV-2 microglia by blocking the TLR4-mediated signal transduction through TLR4/MyD88/NF-κB and MAPK pathways and inhibiting the miR-155 expression. Our findings demonstrated that BA could be a valuable therapeutic for the treatment of neuroinflammation and neurodegenerative diseases." @default.
• W4308653764 created "2022-11-13" @default.
• W4308653764 creator A5024411346 @default.
• W4308653764 creator A5029295964 @default.
• W4308653764 creator A5030556176 @default.
• W4308653764 creator A5030580451 @default.
• W4308653764 creator A5042772858 @default.
• W4308653764 creator A5045518350 @default.
• W4308653764 creator A5049317673 @default.
• W4308653764 creator A5059652566 @default.
• W4308653764 creator A5061168203 @default.
• W4308653764 creator A5084627028 @default.
• W4308653764 creator A5087235952 @default.
• W4308653764 date "2022-11-09" @default.
• W4308653764 modified "2023-10-16" @default.
• W4308653764 title "Baicalin Mitigates the Neuroinflammation through the TLR4/MyD88/NF-κB and MAPK Pathways in LPS-Stimulated BV-2 Microglia" @default.
• W4308653764 cites W1985676180 @default.
• W4308653764 cites W1994925004 @default.
• W4308653764 cites W2009646199 @default.
• W4308653764 cites W2021533121 @default.
• W4308653764 cites W2022130960 @default.
• W4308653764 cites W2033664158 @default.
• W4308653764 cites W2033842971 @default.
• W4308653764 cites W2034778524 @default.
• W4308653764 cites W2037971418 @default.
• W4308653764 cites W2049772720 @default.
• W4308653764 cites W2084043574 @default.
• W4308653764 cites W2094640306 @default.
• W4308653764 cites W2095149099 @default.
• W4308653764 cites W2106118263 @default.
• W4308653764 cites W258344814 @default.
• W4308653764 cites W2589764628 @default.
• W4308653764 cites W2643344220 @default.
• W4308653764 cites W2745854656 @default.
• W4308653764 cites W2774947569 @default.
• W4308653764 cites W2790049389 @default.
• W4308653764 cites W2792813804 @default.
• W4308653764 cites W2801734946 @default.
• W4308653764 cites W2804685648 @default.
• W4308653764 cites W2805799188 @default.
• W4308653764 cites W2921604985 @default.
• W4308653764 cites W2944565277 @default.
• W4308653764 cites W2947067356 @default.
• W4308653764 cites W2972368830 @default.
• W4308653764 cites W2977662739 @default.
• W4308653764 cites W2978315680 @default.
• W4308653764 cites W2978931957 @default.
• W4308653764 cites W3013426051 @default.
• W4308653764 cites W3019397586 @default.
• W4308653764 cites W3023036454 @default.
• W4308653764 cites W3043443440 @default.
• W4308653764 cites W3088489717 @default.
• W4308653764 cites W3091076800 @default.
• W4308653764 cites W3109852039 @default.
• W4308653764 cites W3123391505 @default.
• W4308653764 cites W3135856311 @default.
• W4308653764 cites W3153153914 @default.
• W4308653764 cites W3159025926 @default.
• W4308653764 cites W3182552820 @default.
• W4308653764 cites W3188786131 @default.
• W4308653764 doi "https://doi.org/10.1155/2022/3263446" @default.
• W4308653764 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36408278" @default.
• W4308653764 hasPublicationYear "2022" @default.
• W4308653764 type Work @default.
• W4308653764 citedByCount "4" @default.
• W4308653764 countsByYear W43086537642022 @default.
• W4308653764 countsByYear W43086537642023 @default.
• W4308653764 crossrefType "journal-article" @default.
• W4308653764 hasAuthorship W4308653764A5024411346 @default.
• W4308653764 hasAuthorship W4308653764A5029295964 @default.
• W4308653764 hasAuthorship W4308653764A5030556176 @default.
• W4308653764 hasAuthorship W4308653764A5030580451 @default.
• W4308653764 hasAuthorship W4308653764A5042772858 @default.
• W4308653764 hasAuthorship W4308653764A5045518350 @default.
• W4308653764 hasAuthorship W4308653764A5049317673 @default.
• W4308653764 hasAuthorship W4308653764A5059652566 @default.
• W4308653764 hasAuthorship W4308653764A5061168203 @default.
• W4308653764 hasAuthorship W4308653764A5084627028 @default.
• W4308653764 hasAuthorship W4308653764A5087235952 @default.
• W4308653764 hasBestOaLocation W43086537641 @default.
• W4308653764 hasConcept C11960822 @default.
• W4308653764 hasConcept C184235292 @default.
• W4308653764 hasConcept C185592680 @default.
• W4308653764 hasConcept C203014093 @default.
• W4308653764 hasConcept C2776070231 @default.
• W4308653764 hasConcept C2776914184 @default.
• W4308653764 hasConcept C2777730290 @default.
• W4308653764 hasConcept C2779830541 @default.
• W4308653764 hasConcept C502942594 @default.
• W4308653764 hasConcept C57074206 @default.
• W4308653764 hasConcept C62478195 @default.
• W4308653764 hasConcept C86803240 @default.
• W4308653764 hasConcept C87753298 @default.
• W4308653764 hasConcept C95444343 @default.
• W4308653764 hasConcept C98274493 @default.
• W4308653764 hasConceptScore W4308653764C11960822 @default.
• W4308653764 hasConceptScore W4308653764C184235292 @default.
• W4308653764 hasConceptScore W4308653764C185592680 @default.

• next