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- W4308653804 abstract "Abstract Background Overproduction of reactive oxygen species (ROS) is known to delay wound healing by causing oxidative tissue damage and inflammation. The green tea catechin, (–)-Epigallocatechin-3- O -gallate (EGCG), has drawn a great deal of interest due to its strong ROS scavenging and anti-inflammatory activities. In this study, we developed EGCG-grafted silk fibroin hydrogels as a potential wound dressing material. Methods The introduction of EGCG to water-soluble silk fibroin (SF-WS) was accomplished by the nucleophilic addition reaction between lysine residues in silk proteins and EGCG quinone at mild basic pH. The resulting SF-EGCG conjugate was co-crosslinked with tyramine-substituted SF (SF-T) via horseradish peroxidase (HRP)/H 2 O 2 mediated enzymatic reaction to form SF-T/SF-EGCG hydrogels with series of composition ratios. Results Interestingly, SF-T70/SF-EGCG30 hydrogels exhibited rapid in situ gelation (< 30 s), similar storage modulus to human skin (≈ 1000 Pa) and superior wound healing performance over SF-T hydrogels and a commercial DuoDERM® gel dressings in a rat model of full thickness skin defect. Conclusion This study will provide useful insights into a rational design of ROS scavenging biomaterials for wound healing applications." @default.
- W4308653804 created "2022-11-13" @default.
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- W4308653804 date "2022-11-09" @default.
- W4308653804 modified "2023-10-17" @default.
- W4308653804 title "Green tea catechin-grafted silk fibroin hydrogels with reactive oxygen species scavenging activity for wound healing applications" @default.
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- W4308653804 doi "https://doi.org/10.1186/s40824-022-00304-3" @default.
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