FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308654807> ?p ?o ?g. }

• W4308654807 endingPage "S33" @default.
• W4308654807 startingPage "S33" @default.
• W4308654807 abstract "Abstract Introduction/Objective Aging adults with Down syndrome (DS) develop Alzheimer disease neuropathology (AD) by the age of 40 years, primarily due to the overexpression of the amyloid precursor protein on chromosome 21. Lewy bodies (LBs), containing alpha-synuclein protein, are observed in 7-60% of AD patients in the amygdala and in cortex. Prior DS studies (n=20-56 cases) find the frequency of LB pathology to range between 8-50% of cases being affected. We hypothesized that LB pathology would also be present in DS brain with similar locations and prevalence to AD. Thus, we evaluated the frequency of LB in our UCI cohort of DS cases that we have collected over the past 25 years. Methods/Case Report Neuropathology reports from 55 cases with DS from the UCI-ADRC were included in this study. Cases were stained for beta-amyloid, phosphor-tau, alpha-synuclein and TDP-43 as per NACC protocols (one case each v7,8,9 and three v11). Results (if a Case Study enter NA) We identified 6 cases (10.9%), all male, with a mean age of 57 years (SD=3) that showed LB and/or Lewy neurites. LB pathology was classified as amygdala predominant in 3 cases, brainstem predominant in one, intermediate/transitional in one, and diffuse/neocortical in one. Five cases were BRAAK stage 6 and one was stage 5. Five cases had CERAD neuritic plaque score C and one case had a B score. Two of 3 cases were Thal phase 5, and one was phase 4. The case with diffuse/neocortical LB pathology demonstrated hippocampal sclerosis. Conclusion The observation that all our LB positive cases were male may reflect a sample bias. In our study, Lewy pathology was most common in amygdala but other sites of involvement are seen similar to a prior DS study and AD studies. Prior DS studies (n=20-56 cases) find the frequency of LB pathology to range between 8-50% of cases being affected. The prevalence of LB in our DS cohort (10.9%) is in the low end of the range seen in other DS and AD studies." @default.
• W4308654807 created "2022-11-13" @default.
• W4308654807 creator A5006730382 @default.
• W4308654807 creator A5015191677 @default.
• W4308654807 creator A5016033782 @default.
• W4308654807 creator A5016190247 @default.
• W4308654807 creator A5023639877 @default.
• W4308654807 creator A5031432503 @default.
• W4308654807 creator A5035578354 @default.
• W4308654807 creator A5035732644 @default.
• W4308654807 creator A5060812089 @default.
• W4308654807 creator A5070892687 @default.
• W4308654807 date "2022-11-01" @default.
• W4308654807 modified "2023-09-24" @default.
• W4308654807 title "Lewy Body Pathology and Alzheimer Disease in Down Syndrome" @default.
• W4308654807 doi "https://doi.org/10.1093/ajcp/aqac126.059" @default.
• W4308654807 hasPublicationYear "2022" @default.
• W4308654807 type Work @default.
• W4308654807 citedByCount "0" @default.
• W4308654807 crossrefType "journal-article" @default.
• W4308654807 hasAuthorship W4308654807A5006730382 @default.
• W4308654807 hasAuthorship W4308654807A5015191677 @default.
• W4308654807 hasAuthorship W4308654807A5016033782 @default.
• W4308654807 hasAuthorship W4308654807A5016190247 @default.
• W4308654807 hasAuthorship W4308654807A5023639877 @default.
• W4308654807 hasAuthorship W4308654807A5031432503 @default.
• W4308654807 hasAuthorship W4308654807A5035578354 @default.
• W4308654807 hasAuthorship W4308654807A5035732644 @default.
• W4308654807 hasAuthorship W4308654807A5060812089 @default.
• W4308654807 hasAuthorship W4308654807A5070892687 @default.
• W4308654807 hasBestOaLocation W43086548071 @default.
• W4308654807 hasConcept C126322002 @default.
• W4308654807 hasConcept C142724271 @default.
• W4308654807 hasConcept C2779097696 @default.
• W4308654807 hasConcept C2779134260 @default.
• W4308654807 hasConcept C2779483572 @default.
• W4308654807 hasConcept C2779721402 @default.
• W4308654807 hasConcept C2779734285 @default.
• W4308654807 hasConcept C2780130745 @default.
• W4308654807 hasConcept C2781449126 @default.
• W4308654807 hasConcept C502032728 @default.
• W4308654807 hasConcept C551621295 @default.
• W4308654807 hasConcept C68026918 @default.
• W4308654807 hasConcept C71924100 @default.
• W4308654807 hasConceptScore W4308654807C126322002 @default.
• W4308654807 hasConceptScore W4308654807C142724271 @default.
• W4308654807 hasConceptScore W4308654807C2779097696 @default.
• W4308654807 hasConceptScore W4308654807C2779134260 @default.
• W4308654807 hasConceptScore W4308654807C2779483572 @default.
• W4308654807 hasConceptScore W4308654807C2779721402 @default.
• W4308654807 hasConceptScore W4308654807C2779734285 @default.
• W4308654807 hasConceptScore W4308654807C2780130745 @default.
• W4308654807 hasConceptScore W4308654807C2781449126 @default.
• W4308654807 hasConceptScore W4308654807C502032728 @default.
• W4308654807 hasConceptScore W4308654807C551621295 @default.
• W4308654807 hasConceptScore W4308654807C68026918 @default.
• W4308654807 hasConceptScore W4308654807C71924100 @default.
• W4308654807 hasIssue "Supplement_1" @default.
• W4308654807 hasLocation W43086548071 @default.
• W4308654807 hasOpenAccess W4308654807 @default.
• W4308654807 hasPrimaryLocation W43086548071 @default.
• W4308654807 hasRelatedWork W1968324269 @default.
• W4308654807 hasRelatedWork W1988576448 @default.
• W4308654807 hasRelatedWork W1993598577 @default.
• W4308654807 hasRelatedWork W2022499779 @default.
• W4308654807 hasRelatedWork W2054975950 @default.
• W4308654807 hasRelatedWork W2065382820 @default.
• W4308654807 hasRelatedWork W2114654653 @default.
• W4308654807 hasRelatedWork W2386985152 @default.
• W4308654807 hasRelatedWork W2596001647 @default.
• W4308654807 hasRelatedWork W4308654807 @default.
• W4308654807 hasVolume "158" @default.
• W4308654807 isParatext "false" @default.
• W4308654807 isRetracted "false" @default.
• W4308654807 workType "article" @default.