FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308654832> ?p ?o ?g. }

• W4308654832 endingPage "S115" @default.
• W4308654832 startingPage "S114" @default.
• W4308654832 abstract "Abstract Introduction/Objective Although thrombotic complications from COVID are well documented, the pathophysiology remains poorly understood, especially in patients with comorbid hypercoagulable risk factors and anticoagulant medication use. COVID has several dermatologic manifestations that may occur due to alterations in hemostasis. We present a case of skin necrosis in a patient with protein S deficiency, warfarin anticoagulation, and acute COVID infection. Methods/Case Report A 48-year-old female, BMI &gt;50, heterozygous Protein S (PS) deficiency, Factor V Leiden, and history of recurrent venous thromboembolic events on warfarin, tested positive for COVID. Her only symptom was fatigue. Several days later, the patient developed painful ecchymoses and erythematous blisters on her breast, arm, and abdomen. Laboratory results showed INR 3.6, fibrinogen 675-1054 gm/dL, WBC 15k with absolute neutrophilia, and D-dimer 2274 ug/L DDU. The patient confirmed compliance with her maintenance warfarin dose. Biopsy showed thrombotic vasculopathy without leukocytoclastic vasculitis. Wound cultures were negative. Results (if a Case Study enter NA) NA. Conclusion The patient’s history and presentation were concerning for warfarin induced skin necrosis. However, the patient had taken warfarin for &gt; 20 years and had an INR of 3.6 which substantiated that warfarin was not discontinued or missed. A retrospective review of INR results during acute COVID infection showed a decrease in time in therapeutic range and an increase in supratherapeutic INRs, suggesting COIVD patients may require decreased warfarin doses. Additionally, PS levels decline in patients with COVID; a similar effect is seen with HIV and Varicella infections. It is theorized that this may be mediated by an increase in C4b binding protein, an acute phase reactant that regulates the complement cascade and binds PS. With an infectious source ruled out and the patients’ known comorbid conditions, an acute exacerbation of the patients underlying hypercoagulable state is the likely driver of the patient’s skin necrosis with COVID as the probable precipitator. In summary, inherited and acquired hypercoagulable risk factors should be included in the differential diagnosis as a cause of skin changes in patients with COVID infection. Although histology may be helpful in diagnosing the cause of skin changes with COVID, laboratory results and clinical correlation are key in identifying a etiology." @default.
• W4308654832 created "2022-11-13" @default.
• W4308654832 creator A5022244784 @default.
• W4308654832 creator A5088481673 @default.
• W4308654832 date "2022-11-01" @default.
• W4308654832 modified "2023-09-27" @default.
• W4308654832 title "Skin Necrosis in a Patient with Protein S Deficiency, Warfarin Anticoagulation, and Acute COVID-19 Infection: A Case Report" @default.
• W4308654832 doi "https://doi.org/10.1093/ajcp/aqac126.243" @default.
• W4308654832 hasPublicationYear "2022" @default.
• W4308654832 type Work @default.
• W4308654832 citedByCount "0" @default.
• W4308654832 crossrefType "journal-article" @default.
• W4308654832 hasAuthorship W4308654832A5022244784 @default.
• W4308654832 hasAuthorship W4308654832A5088481673 @default.
• W4308654832 hasBestOaLocation W43086548321 @default.
• W4308654832 hasConcept C126322002 @default.
• W4308654832 hasConcept C141071460 @default.
• W4308654832 hasConcept C2775934546 @default.
• W4308654832 hasConcept C2776301958 @default.
• W4308654832 hasConcept C2778205648 @default.
• W4308654832 hasConcept C2779161974 @default.
• W4308654832 hasConcept C2779936836 @default.
• W4308654832 hasConcept C2780439664 @default.
• W4308654832 hasConcept C2780868729 @default.
• W4308654832 hasConcept C71924100 @default.
• W4308654832 hasConcept C90924648 @default.
• W4308654832 hasConceptScore W4308654832C126322002 @default.
• W4308654832 hasConceptScore W4308654832C141071460 @default.
• W4308654832 hasConceptScore W4308654832C2775934546 @default.
• W4308654832 hasConceptScore W4308654832C2776301958 @default.
• W4308654832 hasConceptScore W4308654832C2778205648 @default.
• W4308654832 hasConceptScore W4308654832C2779161974 @default.
• W4308654832 hasConceptScore W4308654832C2779936836 @default.
• W4308654832 hasConceptScore W4308654832C2780439664 @default.
• W4308654832 hasConceptScore W4308654832C2780868729 @default.
• W4308654832 hasConceptScore W4308654832C71924100 @default.
• W4308654832 hasConceptScore W4308654832C90924648 @default.
• W4308654832 hasIssue "Supplement_1" @default.
• W4308654832 hasLocation W43086548321 @default.
• W4308654832 hasOpenAccess W4308654832 @default.
• W4308654832 hasPrimaryLocation W43086548321 @default.
• W4308654832 hasRelatedWork W1964666267 @default.
• W4308654832 hasRelatedWork W1982083319 @default.
• W4308654832 hasRelatedWork W1995900004 @default.
• W4308654832 hasRelatedWork W2059347561 @default.
• W4308654832 hasRelatedWork W2066076015 @default.
• W4308654832 hasRelatedWork W2102762750 @default.
• W4308654832 hasRelatedWork W2613226312 @default.
• W4308654832 hasRelatedWork W3010511938 @default.
• W4308654832 hasRelatedWork W4308654832 @default.
• W4308654832 hasRelatedWork W49244280 @default.
• W4308654832 hasVolume "158" @default.
• W4308654832 isParatext "false" @default.
• W4308654832 isRetracted "false" @default.
• W4308654832 workType "article" @default.