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- W4308656680 abstract "Depression is a serious psychological disorder with a rapidly increasing incidence in recent years. Clinically, selective serotonin reuptake inhibitors are the main therapy. These drugs, have serious adverse reactions, however. Traditional Chinese medicine has the characteristics of multiple components, targets, and pathways, which has huge potential advantages for the treatment of depression. The antidepressant potential of the herbal combination of Bupleurum chinense DC (Chaihu) and Paeonia lactiflora Pall (Baishao) has been extensively studied previously. In this review, we summarized the antidepressant active components and mechanism of Chaihu-Baishao herb pair. We found that it works mainly through relieving oxidative stress, regulating HPA axis, and protecting neurons. Nevertheless, current research of this combined preparation still faces many challenges. On one hand, most of the current studies only stay at the level of animal models, lacking of sufficient clinical double-blind controlled trials for further verification. In addition, studies on the synergistic effect between different targets and signaling pathways are scarce. On the other hand, this preparation has numerous defects such as poor stability, low solubility, and difficulty in crossing the blood-brain barrier." @default.
- W4308656680 created "2022-11-13" @default.
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- W4308656680 date "2022-11-09" @default.
- W4308656680 modified "2023-10-14" @default.
- W4308656680 title "Antidepressant Active Components of Bupleurum chinense DC-Paeonia lactiflora Pall Herb Pair: Pharmacological Mechanisms" @default.
- W4308656680 cites W1516644432 @default.
- W4308656680 cites W1877874306 @default.
- W4308656680 cites W1968126540 @default.
- W4308656680 cites W1974211482 @default.
- W4308656680 cites W2029819292 @default.
- W4308656680 cites W2041093700 @default.
- W4308656680 cites W2047460164 @default.
- W4308656680 cites W2062195428 @default.
- W4308656680 cites W2110938813 @default.
- W4308656680 cites W2118894415 @default.
- W4308656680 cites W2120423982 @default.
- W4308656680 cites W2135919238 @default.
- W4308656680 cites W2172025063 @default.
- W4308656680 cites W2194350630 @default.
- W4308656680 cites W2194924010 @default.
- W4308656680 cites W2291443053 @default.
- W4308656680 cites W2297606889 @default.
- W4308656680 cites W2343913762 @default.
- W4308656680 cites W2420364616 @default.
- W4308656680 cites W2509102039 @default.
- W4308656680 cites W2540823011 @default.
- W4308656680 cites W2546703801 @default.
- W4308656680 cites W2560755289 @default.
- W4308656680 cites W2563662605 @default.
- W4308656680 cites W2585808900 @default.
- W4308656680 cites W2588253285 @default.
- W4308656680 cites W2626326504 @default.
- W4308656680 cites W2738299024 @default.
- W4308656680 cites W2739162726 @default.
- W4308656680 cites W2744579607 @default.
- W4308656680 cites W2751562963 @default.
- W4308656680 cites W2755801764 @default.
- W4308656680 cites W2758711862 @default.
- W4308656680 cites W2789018622 @default.
- W4308656680 cites W2799652277 @default.
- W4308656680 cites W2801253301 @default.
- W4308656680 cites W2896342012 @default.
- W4308656680 cites W2902518856 @default.
- W4308656680 cites W2909025052 @default.
- W4308656680 cites W2909641326 @default.
- W4308656680 cites W2911969473 @default.
- W4308656680 cites W2912526391 @default.
- W4308656680 cites W2913027830 @default.
- W4308656680 cites W2913233769 @default.
- W4308656680 cites W2921154995 @default.
- W4308656680 cites W2938063442 @default.
- W4308656680 cites W2944967298 @default.
- W4308656680 cites W2944972170 @default.
- W4308656680 cites W2945280411 @default.
- W4308656680 cites W2945571967 @default.
- W4308656680 cites W2947540556 @default.
- W4308656680 cites W2947815139 @default.
- W4308656680 cites W2969919519 @default.
- W4308656680 cites W2979904024 @default.
- W4308656680 cites W2988304170 @default.
- W4308656680 cites W2990086160 @default.
- W4308656680 cites W2998820762 @default.
- W4308656680 cites W2998986963 @default.
- W4308656680 cites W2999086307 @default.
- W4308656680 cites W3001554865 @default.
- W4308656680 cites W3010266650 @default.
- W4308656680 cites W3024031239 @default.
- W4308656680 cites W3029385222 @default.
- W4308656680 cites W3033040644 @default.
- W4308656680 cites W3038020227 @default.
- W4308656680 cites W3041041132 @default.
- W4308656680 cites W3043043206 @default.
- W4308656680 cites W3043757489 @default.
- W4308656680 cites W3049502358 @default.
- W4308656680 cites W3053258398 @default.
- W4308656680 cites W3092138369 @default.
- W4308656680 cites W3108121109 @default.
- W4308656680 cites W3124459208 @default.
- W4308656680 cites W3133646904 @default.
- W4308656680 cites W3139475596 @default.
- W4308656680 cites W3155818515 @default.
- W4308656680 cites W3158143766 @default.
- W4308656680 cites W3187020603 @default.
- W4308656680 cites W4235193083 @default.
- W4308656680 doi "https://doi.org/10.1155/2022/1024693" @default.