FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308657835> ?p ?o ?g. }

• W4308657835 abstract "Abstract Background Following central nervous system (CNS) injury, the investigation for neuroinflammation is vital because of its pleiotropic role in both acute injury and long-term recovery. Agmatine (Agm) is well known for its neuroprotective effects and anti-neuroinflammatory properties. However, Agm’s mechanism for neuroprotection is still unclear. We screened target proteins that bind to Agm using a protein microarray; the results showed that Agm strongly binds to interferon regulatory factor 2 binding protein (IRF2BP2), which partakes in the inflammatory response. Methods To confirm the relationship between Agm and IRF2BP2 in neuroinflammation, we used microglia cell-line (BV2) and treated with lipopolysaccharide (LPS; 20 ng/ml) and interleukin (IL)-4 (20 ng/ml). Although Agm bound to IRF2BP2, it failed to enhance IRF2BP2 expression in BV2. Therefore, we shifted our focus onto interferon regulatory factor 2 (IRF2), which is a transcription factor and interacts with IRF2BP2. Results IRF2 was highly expressed in BV2 after LPS treatment but not after IL-4 treatment. When Agm bound to IRF2BP2 following Agm treatment, the free IRF2 translocated to the nucleus of BV2. The translocated IRF2 activated the transcription of Kruppel-like factor 4 (KLF4), causing KLF4 to be induced in BV2. The expression of KLF4 increased the CD206-positive cells in BV2. Conclusion Taken together, unbound IRF2, resulting from the competitive binding of Agm to IRF2BP2, may provide protection against neuroinflammation via an anti-inflammatory mechanism of microglia involving the expression of KLF4." @default.
• W4308657835 created "2022-11-13" @default.
• W4308657835 creator A5043729394 @default.
• W4308657835 creator A5049410535 @default.
• W4308657835 creator A5051275961 @default.
• W4308657835 creator A5071375322 @default.
• W4308657835 creator A5091554389 @default.
• W4308657835 date "2022-11-09" @default.
• W4308657835 modified "2023-10-14" @default.
• W4308657835 title "Unbound IRF2 to IRF2BP2 mediates KLF4 signaling leading to anti-inflammatory phenotype of microglia" @default.
• W4308657835 cites W1513989058 @default.
• W4308657835 cites W1969673099 @default.
• W4308657835 cites W1972296893 @default.
• W4308657835 cites W1976789655 @default.
• W4308657835 cites W1993401937 @default.
• W4308657835 cites W2001510869 @default.
• W4308657835 cites W2004930517 @default.
• W4308657835 cites W2009761514 @default.
• W4308657835 cites W2011566054 @default.
• W4308657835 cites W2025638147 @default.
• W4308657835 cites W2027768860 @default.
• W4308657835 cites W2030868360 @default.
• W4308657835 cites W2035966233 @default.
• W4308657835 cites W2048295632 @default.
• W4308657835 cites W2054682292 @default.
• W4308657835 cites W2060192065 @default.
• W4308657835 cites W2066060929 @default.
• W4308657835 cites W2076636516 @default.
• W4308657835 cites W2108175051 @default.
• W4308657835 cites W2109342780 @default.
• W4308657835 cites W2113104975 @default.
• W4308657835 cites W2122547951 @default.
• W4308657835 cites W2123751639 @default.
• W4308657835 cites W2129388376 @default.
• W4308657835 cites W2131939356 @default.
• W4308657835 cites W2163711719 @default.
• W4308657835 cites W2168059813 @default.
• W4308657835 cites W2169215537 @default.
• W4308657835 cites W2214810997 @default.
• W4308657835 cites W2240976091 @default.
• W4308657835 cites W2331864886 @default.
• W4308657835 cites W2361134965 @default.
• W4308657835 cites W2524252803 @default.
• W4308657835 cites W2739038514 @default.
• W4308657835 cites W2743457301 @default.
• W4308657835 cites W2764291671 @default.
• W4308657835 cites W2794031016 @default.
• W4308657835 cites W2890731495 @default.
• W4308657835 cites W2941631016 @default.
• W4308657835 cites W3158661999 @default.
• W4308657835 doi "https://doi.org/10.21203/rs.3.rs-2232738/v1" @default.
• W4308657835 hasPublicationYear "2022" @default.
• W4308657835 type Work @default.
• W4308657835 citedByCount "0" @default.
• W4308657835 crossrefType "posted-content" @default.
• W4308657835 hasAuthorship W4308657835A5043729394 @default.
• W4308657835 hasAuthorship W4308657835A5049410535 @default.
• W4308657835 hasAuthorship W4308657835A5051275961 @default.
• W4308657835 hasAuthorship W4308657835A5071375322 @default.
• W4308657835 hasAuthorship W4308657835A5091554389 @default.
• W4308657835 hasBestOaLocation W43086578351 @default.
• W4308657835 hasConcept C104317684 @default.
• W4308657835 hasConcept C185592680 @default.
• W4308657835 hasConcept C203014093 @default.
• W4308657835 hasConcept C25498285 @default.
• W4308657835 hasConcept C2776914184 @default.
• W4308657835 hasConcept C2777933648 @default.
• W4308657835 hasConcept C2778265714 @default.
• W4308657835 hasConcept C2779830541 @default.
• W4308657835 hasConcept C502942594 @default.
• W4308657835 hasConcept C55493867 @default.
• W4308657835 hasConcept C86339819 @default.
• W4308657835 hasConcept C86803240 @default.
• W4308657835 hasConcept C87753298 @default.
• W4308657835 hasConcept C95444343 @default.
• W4308657835 hasConcept C98274493 @default.
• W4308657835 hasConceptScore W4308657835C104317684 @default.
• W4308657835 hasConceptScore W4308657835C185592680 @default.
• W4308657835 hasConceptScore W4308657835C203014093 @default.
• W4308657835 hasConceptScore W4308657835C25498285 @default.
• W4308657835 hasConceptScore W4308657835C2776914184 @default.
• W4308657835 hasConceptScore W4308657835C2777933648 @default.
• W4308657835 hasConceptScore W4308657835C2778265714 @default.
• W4308657835 hasConceptScore W4308657835C2779830541 @default.
• W4308657835 hasConceptScore W4308657835C502942594 @default.
• W4308657835 hasConceptScore W4308657835C55493867 @default.
• W4308657835 hasConceptScore W4308657835C86339819 @default.
• W4308657835 hasConceptScore W4308657835C86803240 @default.
• W4308657835 hasConceptScore W4308657835C87753298 @default.
• W4308657835 hasConceptScore W4308657835C95444343 @default.
• W4308657835 hasConceptScore W4308657835C98274493 @default.
• W4308657835 hasLocation W43086578351 @default.
• W4308657835 hasOpenAccess W4308657835 @default.
• W4308657835 hasPrimaryLocation W43086578351 @default.
• W4308657835 hasRelatedWork W1968744284 @default.
• W4308657835 hasRelatedWork W1968895059 @default.
• W4308657835 hasRelatedWork W2046477056 @default.
• W4308657835 hasRelatedWork W2068549596 @default.
• W4308657835 hasRelatedWork W2069473589 @default.
• W4308657835 hasRelatedWork W2232520593 @default.

• next