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- W4308662633 abstract "High-grade serous ovarian carcinoma (HGSOC) represents the most common form of epithelial ovarian carcinoma. The absence of specific symptoms leads to late-stage diagnosis, making HGSOC one of the gynecological cancers with the worst prognosis. The cellular origin of HGSOC and the role of reproductive hormones, genetic traits (such as alterations in P53 and DNA-repair mechanisms), chromosomal instability, or dysregulation of crucial signaling pathways have been considered when evaluating prognosis and response to therapy in HGSOC patients. However, the detection of HGSOC is still based on traditional methods such as carbohydrate antigen 125 (CA125) detection and ultrasound, and the combined use of these methods has yet to support significant reductions in overall mortality rates. The current paradigm for HGSOC management has moved towards early diagnosis via the non-invasive detection of molecular markers through liquid biopsies. This review presents an integrated view of the relevant cellular and molecular aspects involved in the etiopathogenesis of HGSOC and brings together studies that consider new horizons for the possible early detection of this gynecological cancer." @default.
- W4308662633 created "2022-11-13" @default.
- W4308662633 creator A5020719274 @default.
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- W4308662633 creator A5058700106 @default.
- W4308662633 creator A5071127874 @default.
- W4308662633 creator A5090345459 @default.
- W4308662633 date "2022-11-09" @default.
- W4308662633 modified "2023-10-05" @default.
- W4308662633 title "Molecular Management of High-Grade Serous Ovarian Carcinoma" @default.
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