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- W4308667316 abstract "Nature connects multiple fuel-driven chemical/enzymatic reaction networks (CRNs/ERNs) via cross-regulation to hierarchically control biofunctions for a tailored adaption in complex sensory landscapes. Herein, we introduce a facile example of communication and cross-regulation among two fuel-driven DNA-based ERNs regulated by a concatenated RNA transcription regulator. ERN1 (sender) is designed for the fuel-driven promoter formation for T7 RNA polymerase, which activates RNA transcription. The produced RNA can deactivate or activate DNA in ERN2 (receiver) by toehold-mediated strand displacement, leading to a communication between two ERNs. The RNA from ERN1 can repress or promote the fuel-driven state of ERN2; ERN2 in turn feedbacks to regulate the lifetime of ERN1. Furthermore, the incorporation of RNase H allows for RNA degradation and enables the autonomous recovery of ERN2. We believe that concatenation of multiple CRNs/ERNs provides a basis for the design of more elaborate autonomous regulatory mechanisms in systems chemistry and synthetic biology." @default.
- W4308667316 created "2022-11-14" @default.
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- W4308667316 date "2022-12-07" @default.
- W4308667316 modified "2023-10-01" @default.
- W4308667316 title "Communication and Cross‐Regulation between Chemically Fueled Sender and Receiver Reaction Networks**" @default.
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- W4308667316 doi "https://doi.org/10.1002/anie.202214499" @default.
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