FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308678873> ?p ?o ?g. }

• W4308678873 endingPage "132" @default.
• W4308678873 startingPage "120" @default.
• W4308678873 abstract "Gestational dyslipidemia is associated with pregnancy complications including preeclampsia. However, whether gestational dyslipidemia leads postpartum vascular dysfunction, which could increase the risk for cardiovascular complications later in life, is not known. Here, we aimed to determine whether a gestational dyslipidemia affects postpartum vascular health and induces early signs of atherosclerosis.Pregnant C57BL/6 mice received a high cholesterol diet or control diet from gestational day 13.5 until term. After delivery, all mice received the control diet for ≈3 months postpartum (PP). Age-matched nulliparous females were on the same diets for equal periods. After 3 months, all mice were euthanized, serum was collected, and aortas were isolated to assess vascular function (wire myography) and markers of oxidative stress and early atherosclerosis.PP-high cholesterol diet females had increased circulating cholesterol levels compared with PP-control diet mice, without effect of the diet in nulliparous mice. Methacholine-induced vasodilation was impaired, and nitric oxide contribution reduced, by the high cholesterol diet in aortas of PP mice, but not in nulliparous mice. Exposure to oxidized low-density-protein cholesterol further impaired methylcholine-induced vasodilation in PP-high cholesterol diet aortas only. Compared with PP-control diet mice, aortic inducible nitric oxide synthase expression, reactive oxygen species and nitrotyrosine levels were increased in aortas from PP-high cholesterol diet mice. No differences in aortic lipid deposition and macrophage infiltration were found.Exposure to a high cholesterol diet in pregnancy impairs vascular function postpartum. Our results support the hypothesis that gestational dyslipidemia impacts maternal vascular function after pregnancy, which could potentially predispose these women to future cardiovascular complications." @default.
• W4308678873 created "2022-11-14" @default.
• W4308678873 creator A5034605507 @default.
• W4308678873 creator A5055933789 @default.
• W4308678873 creator A5059960340 @default.
• W4308678873 creator A5072707512 @default.
• W4308678873 creator A5075988596 @default.
• W4308678873 creator A5087842834 @default.
• W4308678873 date "2023-01-01" @default.
• W4308678873 modified "2023-10-16" @default.
• W4308678873 title "A High Cholesterol Diet During Late Pregnancy Impairs Long-Term Maternal Vascular Function in Mice" @default.
• W4308678873 cites W1558405571 @default.
• W4308678873 cites W1866418008 @default.
• W4308678873 cites W1973610105 @default.
• W4308678873 cites W1983534161 @default.
• W4308678873 cites W1991523990 @default.
• W4308678873 cites W1997598917 @default.
• W4308678873 cites W1997803584 @default.
• W4308678873 cites W2034351432 @default.
• W4308678873 cites W2045856626 @default.
• W4308678873 cites W2046479327 @default.
• W4308678873 cites W2053627832 @default.
• W4308678873 cites W2064997884 @default.
• W4308678873 cites W2099540110 @default.
• W4308678873 cites W2101617109 @default.
• W4308678873 cites W2107272046 @default.
• W4308678873 cites W2109047597 @default.
• W4308678873 cites W2117816931 @default.
• W4308678873 cites W2127922258 @default.
• W4308678873 cites W2129158647 @default.
• W4308678873 cites W2132859583 @default.
• W4308678873 cites W2148539755 @default.
• W4308678873 cites W2148609678 @default.
• W4308678873 cites W2156191298 @default.
• W4308678873 cites W2183123378 @default.
• W4308678873 cites W2214405442 @default.
• W4308678873 cites W2522895476 @default.
• W4308678873 cites W2549971560 @default.
• W4308678873 cites W2587858407 @default.
• W4308678873 cites W2589164015 @default.
• W4308678873 cites W2635293305 @default.
• W4308678873 cites W2760540656 @default.
• W4308678873 cites W2767317750 @default.
• W4308678873 cites W2768191254 @default.
• W4308678873 cites W2803203272 @default.
• W4308678873 cites W2890342895 @default.
• W4308678873 cites W2899004655 @default.
• W4308678873 cites W2900034165 @default.
• W4308678873 cites W2900512919 @default.
• W4308678873 cites W2903778820 @default.
• W4308678873 cites W2928139176 @default.
• W4308678873 cites W2929617986 @default.
• W4308678873 cites W2938688210 @default.
• W4308678873 cites W2944735878 @default.
• W4308678873 cites W2947148115 @default.
• W4308678873 cites W2984614226 @default.
• W4308678873 cites W2987502892 @default.
• W4308678873 cites W2988988674 @default.
• W4308678873 cites W3006848668 @default.
• W4308678873 cites W3013073007 @default.
• W4308678873 cites W3081542960 @default.
• W4308678873 cites W3125049136 @default.
• W4308678873 cites W3132102198 @default.
• W4308678873 cites W3157052932 @default.
• W4308678873 cites W3185517415 @default.
• W4308678873 cites W3217207207 @default.
• W4308678873 doi "https://doi.org/10.1161/atvbaha.122.318421" @default.
• W4308678873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36353990" @default.
• W4308678873 hasPublicationYear "2023" @default.
• W4308678873 type Work @default.
• W4308678873 citedByCount "2" @default.
• W4308678873 countsByYear W43086788732023 @default.
• W4308678873 crossrefType "journal-article" @default.
• W4308678873 hasAuthorship W4308678873A5034605507 @default.
• W4308678873 hasAuthorship W4308678873A5055933789 @default.
• W4308678873 hasAuthorship W4308678873A5059960340 @default.
• W4308678873 hasAuthorship W4308678873A5072707512 @default.
• W4308678873 hasAuthorship W4308678873A5075988596 @default.
• W4308678873 hasAuthorship W4308678873A5087842834 @default.
• W4308678873 hasBestOaLocation W43086788731 @default.
• W4308678873 hasConcept C126322002 @default.
• W4308678873 hasConcept C134018914 @default.
• W4308678873 hasConcept C2776151105 @default.
• W4308678873 hasConcept C2777218350 @default.
• W4308678873 hasConcept C2777622882 @default.
• W4308678873 hasConcept C2778096610 @default.
• W4308678873 hasConcept C2778163477 @default.
• W4308678873 hasConcept C2779234561 @default.
• W4308678873 hasConcept C2779385521 @default.
• W4308678873 hasConcept C2780972559 @default.
• W4308678873 hasConcept C519581460 @default.
• W4308678873 hasConcept C54355233 @default.
• W4308678873 hasConcept C555293320 @default.
• W4308678873 hasConcept C71924100 @default.
• W4308678873 hasConcept C86803240 @default.
• W4308678873 hasConceptScore W4308678873C126322002 @default.
• W4308678873 hasConceptScore W4308678873C134018914 @default.
• W4308678873 hasConceptScore W4308678873C2776151105 @default.

• next