FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4308679229> ?p ?o ?g. }

• W4308679229 endingPage "19154" @default.
• W4308679229 startingPage "19145" @default.
• W4308679229 abstract "Neurotoxins attack and destruct the nervous system, which can cause serious health problems and security threats. Existing detoxification approaches, such as antibodies and small molecule antidotes, rely on neurotoxin's molecular structure as design cues and require toxin-specific development for each type of toxins. However, the enormous diversity of neurotoxins makes such structure-based development of antitoxin particularly challenging and inefficient. Here, we report on the development and use of neuronal membrane-coated nanosponges (denoted Neuron-NS) as an effective approach to detoxifying neurotoxins. Specifically, Neuron-NS act as neuron decoys to lure neurotoxins, bind with and neutralize the toxins, and thus block them from attacking the host neuron cells. These nanosponges detoxify neurotoxins regardless of their molecular structures and therefore can overcome the challenge posed by toxin structural diversity. In the study, we fabricate Neuron-NS by coating the membrane of Neuro-2a cells onto polymeric cores. Meanwhile, we select tetrodotoxin (TTX) as a model neurotoxin and demonstrate the detoxification efficacy of the Neuron-NS in a cytotoxicity assay, a calcium flux assay, and a cell osmotic swelling assay in vitro. Additionally, in mouse models of TTX intoxication, the Neuron-NS significantly enhance mouse survival in therapeutic and prophylactic regimens without showing acute toxicity. Overall, the Neuron-NS contribute to the current detoxification arsenal with the potential to treat various injuries and diseases caused by neurotoxins." @default.
• W4308679229 created "2022-11-14" @default.
• W4308679229 creator A5053960860 @default.
• W4308679229 creator A5058380236 @default.
• W4308679229 creator A5068365109 @default.
• W4308679229 creator A5075816686 @default.
• W4308679229 creator A5080796252 @default.
• W4308679229 creator A5083005519 @default.
• W4308679229 creator A5084122819 @default.
• W4308679229 date "2022-11-10" @default.
• W4308679229 modified "2023-10-15" @default.
• W4308679229 title "Neuronal Cellular Nanosponges for Effective Detoxification of Neurotoxins" @default.
• W4308679229 cites W1555110619 @default.
• W4308679229 cites W1975670424 @default.
• W4308679229 cites W2023303116 @default.
• W4308679229 cites W2026125511 @default.
• W4308679229 cites W2028922575 @default.
• W4308679229 cites W2029293181 @default.
• W4308679229 cites W2029591817 @default.
• W4308679229 cites W2042634738 @default.
• W4308679229 cites W2050559962 @default.
• W4308679229 cites W2053929414 @default.
• W4308679229 cites W2056667374 @default.
• W4308679229 cites W2087269887 @default.
• W4308679229 cites W2105365201 @default.
• W4308679229 cites W2112668107 @default.
• W4308679229 cites W2140801307 @default.
• W4308679229 cites W2145479354 @default.
• W4308679229 cites W2154864881 @default.
• W4308679229 cites W2157512308 @default.
• W4308679229 cites W2158103040 @default.
• W4308679229 cites W2295059496 @default.
• W4308679229 cites W2326826677 @default.
• W4308679229 cites W2408486274 @default.
• W4308679229 cites W2592972690 @default.
• W4308679229 cites W2767427307 @default.
• W4308679229 cites W2791781448 @default.
• W4308679229 cites W2794683780 @default.
• W4308679229 cites W2889191136 @default.
• W4308679229 cites W2891607011 @default.
• W4308679229 cites W2909717641 @default.
• W4308679229 cites W2922022049 @default.
• W4308679229 cites W2946642476 @default.
• W4308679229 cites W2950771738 @default.
• W4308679229 cites W2974255582 @default.
• W4308679229 cites W2979424799 @default.
• W4308679229 cites W2990262552 @default.
• W4308679229 cites W3022531941 @default.
• W4308679229 cites W3036248212 @default.
• W4308679229 cites W3087216036 @default.
• W4308679229 cites W3119942887 @default.
• W4308679229 cites W3134750990 @default.
• W4308679229 cites W3171606172 @default.
• W4308679229 cites W3183980872 @default.
• W4308679229 cites W3206368049 @default.
• W4308679229 cites W3208928694 @default.
• W4308679229 cites W3211800313 @default.
• W4308679229 cites W4226362235 @default.
• W4308679229 cites W4230454584 @default.
• W4308679229 cites W4254844215 @default.
• W4308679229 cites W634813441 @default.
• W4308679229 doi "https://doi.org/10.1021/acsnano.2c08319" @default.
• W4308679229 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/36354967" @default.
• W4308679229 hasPublicationYear "2022" @default.
• W4308679229 type Work @default.
• W4308679229 citedByCount "9" @default.
• W4308679229 countsByYear W43086792292023 @default.
• W4308679229 crossrefType "journal-article" @default.
• W4308679229 hasAuthorship W4308679229A5053960860 @default.
• W4308679229 hasAuthorship W4308679229A5058380236 @default.
• W4308679229 hasAuthorship W4308679229A5068365109 @default.
• W4308679229 hasAuthorship W4308679229A5075816686 @default.
• W4308679229 hasAuthorship W4308679229A5080796252 @default.
• W4308679229 hasAuthorship W4308679229A5083005519 @default.
• W4308679229 hasAuthorship W4308679229A5084122819 @default.
• W4308679229 hasConcept C12554922 @default.
• W4308679229 hasConcept C142724271 @default.
• W4308679229 hasConcept C169760540 @default.
• W4308679229 hasConcept C178790620 @default.
• W4308679229 hasConcept C185592680 @default.
• W4308679229 hasConcept C204787440 @default.
• W4308679229 hasConcept C2776741303 @default.
• W4308679229 hasConcept C2778794669 @default.
• W4308679229 hasConcept C2779491297 @default.
• W4308679229 hasConcept C2780358027 @default.
• W4308679229 hasConcept C2780497538 @default.
• W4308679229 hasConcept C29730261 @default.
• W4308679229 hasConcept C55493867 @default.
• W4308679229 hasConcept C71924100 @default.
• W4308679229 hasConcept C86803240 @default.
• W4308679229 hasConceptScore W4308679229C12554922 @default.
• W4308679229 hasConceptScore W4308679229C142724271 @default.
• W4308679229 hasConceptScore W4308679229C169760540 @default.
• W4308679229 hasConceptScore W4308679229C178790620 @default.
• W4308679229 hasConceptScore W4308679229C185592680 @default.
• W4308679229 hasConceptScore W4308679229C204787440 @default.
• W4308679229 hasConceptScore W4308679229C2776741303 @default.
• W4308679229 hasConceptScore W4308679229C2778794669 @default.

• next